Molecules 2005, 10(8), 1015-1020; doi:10.3390/10081015
Article

Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers

Jr. 1,* email, 2, 2, 2 and 2
Received: 10 December 2004; in revised form: 27 May 2005 / Accepted: 26 May 2005 / Published: 31 August 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: 6-Methylpurine-β-D-riboside (β-D-MPR) has been synthesized by coupling6-methylpurine and 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribose using conditions that producethe β-D-anomer exclusively. The in vitro antitumor effects of β-D-MPR and 6-methyl-purine-α-D-riboside (α-D-MPR) in five human tumor cell lines showed that β-D-MPR washighly active (IC50 values ranging from 6 to 34 nM). α-D-MPR, although less active than β-D-MPR, also exhibited significant antitumor effects (IC50 values ranging from 1.47 to 4.83"µ"M).
Keywords: 6-Methylpurine-β-D-riboside; 6-methylpurine-α-D-riboside; antitumor activity; synthesis
PDF Full-text Download PDF Full-Text [53 KB, uploaded 18 June 2014 19:26 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Marasco, C., Jr.; Pera, P.; Spiess, A.; Bernacki, R.; Sufrin, J. Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers. Molecules 2005, 10, 1015-1020.

AMA Style

Marasco C, Jr, Pera P, Spiess A, Bernacki R, Sufrin J. Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers. Molecules. 2005; 10(8):1015-1020.

Chicago/Turabian Style

Marasco, C., Jr.; Pera, P.; Spiess, A.; Bernacki, R.; Sufrin, J. 2005. "Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers." Molecules 10, no. 8: 1015-1020.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert