Next Article in Journal
Special Issue: Selected Papers from the 2nd International Conference on Natural Products and Physiologically Active Substances (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry” (EAHM-2004)
Previous Article in Journal
Preparation of an Eight-Membered Sesquiterpene Lactone Resulting from Sequential Gif System GoAggIII and MCPBA Oxidation of ( )-10β,14-Dihydroxy-allo-aromadendrane
Article Menu

Export Article

Open AccessArticle
Molecules 2005, 10(8), 1015-1020; doi:10.3390/10081015

Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers

1
D’Youville College, Department of Math and Natural Sciences, USA
2
Grace Cancer Drug Center, Roswell Park Cancer Institute, USA
*
Author to whom correspondence should be addressed.
Received: 10 December 2004 / Revised: 27 May 2005 / Accepted: 26 May 2005 / Published: 31 August 2005
View Full-Text   |   Download PDF [53 KB, uploaded 18 June 2014]   |  

Abstract

6-Methylpurine-β-D-riboside (β-D-MPR) has been synthesized by coupling6-methylpurine and 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribose using conditions that producethe β-D-anomer exclusively. The in vitro antitumor effects of β-D-MPR and 6-methyl-purine-α-D-riboside (α-D-MPR) in five human tumor cell lines showed that β-D-MPR washighly active (IC50 values ranging from 6 to 34 nM). α-D-MPR, although less active than β-D-MPR, also exhibited significant antitumor effects (IC50 values ranging from 1.47 to 4.83"µ"M). View Full-Text
Keywords: 6-Methylpurine-β-D-riboside; 6-methylpurine-α-D-riboside; antitumor activity; synthesis 6-Methylpurine-β-D-riboside; 6-methylpurine-α-D-riboside; antitumor activity; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Marasco, C., Jr.; Pera, P.; Spiess, A.; Bernacki, R.; Sufrin, J. Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers. Molecules 2005, 10, 1015-1020.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top