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Molecules 2005, 10(7), 762-766; doi:10.3390/10070762
Article

Pechmann Reaction Promoted by Boron Trifluoride Dihydrate

1,*  and 2
1 Faculty of Pharmacy, Medical University of Sofia, Bulgaria 2 Fachhochschule Aalen, Germany
* Author to whom correspondence should be addressed.
Received: 8 October 2004 / Revised: 21 October 2004 / Accepted: 18 December 2004 / Published: 31 August 2005
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Abstract

The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methyl- coumarin derivatives 4a-e in excellent yield (98-99 %).
Keywords: Pechmann Reaction; 4-methylcoumarins; boron trifluoride dihydrate. Pechmann Reaction; 4-methylcoumarins; boron trifluoride dihydrate.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Stoyanov, E.; Mezger, J. Pechmann Reaction Promoted by Boron Trifluoride Dihydrate. Molecules 2005, 10, 762-766.

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