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Molecules 2005, 10(7), 762-766; doi:10.3390/10070762

Pechmann Reaction Promoted by Boron Trifluoride Dihydrate

1,*  and 2
1 Faculty of Pharmacy, Medical University of Sofia, Bulgaria 2 Fachhochschule Aalen, Germany
* Author to whom correspondence should be addressed.
Received: 8 October 2004 / Revised: 21 October 2004 / Accepted: 18 December 2004 / Published: 31 August 2005
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The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methyl- coumarin derivatives 4a-e in excellent yield (98-99 %).
Keywords: Pechmann Reaction; 4-methylcoumarins; boron trifluoride dihydrate. Pechmann Reaction; 4-methylcoumarins; boron trifluoride dihydrate.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Stoyanov, E.; Mezger, J. Pechmann Reaction Promoted by Boron Trifluoride Dihydrate. Molecules 2005, 10, 762-766.

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