Pechmann Reaction Promoted by Boron Trifluoride Dihydrate

doi:10.3390/10070762

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Molecules 2005, 10(7), 762-766; doi:10.3390/10070762

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Pechmann Reaction Promoted by Boron Trifluoride Dihydrate

E. Stoyanov^1,* and J. Mezger²

¹ Faculty of Pharmacy, Medical University of Sofia, Bulgaria ² Fachhochschule Aalen, Germany

* Author to whom correspondence should be addressed.

Received: 8 October 2004; in revised form: 21 October 2004 / Accepted: 18 December 2004 / Published: 31 August 2005

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Abstract: The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methyl- coumarin derivatives 4a-e in excellent yield (98-99 %).

Keywords: Pechmann Reaction; 4-methylcoumarins; boron trifluoride dihydrate.

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MDPI and ACS Style

Stoyanov, E.; Mezger, J. Pechmann Reaction Promoted by Boron Trifluoride Dihydrate. Molecules 2005, 10, 762-766.

AMA Style

Stoyanov E, Mezger J. Pechmann Reaction Promoted by Boron Trifluoride Dihydrate. Molecules. 2005; 10(7):762-766.

Chicago/Turabian Style

Stoyanov, E.; Mezger, J. 2005. "Pechmann Reaction Promoted by Boron Trifluoride Dihydrate." Molecules 10, no. 7: 762-766.

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