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Molecules 2005, 10(7), 755-761; doi:10.3390/10070755
Article

Three-Component Synthesis of Polysubstituted Homoproline Analogs

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Received: 16 July 2004; in revised form: 28 December 2004 / Accepted: 1 January 2005 / Published: 31 August 2005
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Abstract: Tetrasubstituted pyrrolidines representing analogs of homoproline weresynthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagineand N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configurationat the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.
Keywords: Multicomponent reactions; 1; 3-dipolar cycloaddition; homoproline. Multicomponent reactions; 1; 3-dipolar cycloaddition; homoproline.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kudryavtsev, K.; Irkha, V. Three-Component Synthesis of Polysubstituted Homoproline Analogs. Molecules 2005, 10, 755-761.

AMA Style

Kudryavtsev K, Irkha V. Three-Component Synthesis of Polysubstituted Homoproline Analogs. Molecules. 2005; 10(7):755-761.

Chicago/Turabian Style

Kudryavtsev, K.; Irkha, V. 2005. "Three-Component Synthesis of Polysubstituted Homoproline Analogs." Molecules 10, no. 7: 755-761.



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