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Molecules 2005, 10(7), 755-761; doi:10.3390/10070755
Article

Three-Component Synthesis of Polysubstituted Homoproline Analogs

*  and
Received: 16 July 2004 / Revised: 28 December 2004 / Accepted: 1 January 2005 / Published: 31 August 2005
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Abstract

Tetrasubstituted pyrrolidines representing analogs of homoproline weresynthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagineand N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configurationat the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.
Keywords: Multicomponent reactions; 1; 3-dipolar cycloaddition; homoproline. Multicomponent reactions; 1; 3-dipolar cycloaddition; homoproline.
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Kudryavtsev, K.; Irkha, V. Three-Component Synthesis of Polysubstituted Homoproline Analogs. Molecules 2005, 10, 755-761.

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