Next Article in Journal
Pechmann Reaction Promoted by Boron Trifluoride Dihydrate
Previous Article in Journal
Studies on the Synthesis and Reactivity of Novel Benzofuran-2-yl-[3-Methyl-3-Phenylcyclobutyl] Methanones and their Antimicrobial Activity
Molecules 2005, 10(7), 755-761; doi:10.3390/10070755

Three-Component Synthesis of Polysubstituted Homoproline Analogs

*  and
Department of Chemistry, Moscow State University, Russian Federation
* Author to whom correspondence should be addressed.
Received: 16 July 2004 / Revised: 28 December 2004 / Accepted: 1 January 2005 / Published: 31 August 2005
Download PDF [164 KB, uploaded 18 June 2014]


Tetrasubstituted pyrrolidines representing analogs of homoproline weresynthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagineand N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configurationat the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.
Keywords: Multicomponent reactions; 1; 3-dipolar cycloaddition; homoproline. Multicomponent reactions; 1; 3-dipolar cycloaddition; homoproline.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Kudryavtsev, K.; Irkha, V. Three-Component Synthesis of Polysubstituted Homoproline Analogs. Molecules 2005, 10, 755-761.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert