Next Article in Journal
Epoxidation and Reduction of DHEA, 1,4,6-Androstatrien-3-one and 4,6-Androstadien-3β,17β-diol
Previous Article in Journal
Synthesis of Some Phenylpropanoid Monoglycerides via the Mitsunobu Protocol
Article Menu

Export Article

Open AccessArticle
Molecules 2005, 10(3), 559-571; doi:10.3390/10030559

Experimental and Theoretical Studies on the Functionalization Reactions of 4-Benzoyl-1,5-Diphenyl-1H-Pyrazole-3-Carboxylic Acid and Acid Chloride with 2,3-Diaminopyridine

1
Department of Chemistry, Erciyes University, 38039, Kayseri, Turkey
2
Department of Chemistry, Kocaeli University, 41300, Izmit, Turkey
*
Author to whom correspondence should be addressed.
Received: 17 July 2004 / Revised: 28 December 2004 / Accepted: 4 January 2005 / Published: 31 March 2005
View Full-Text   |   Download PDF [317 KB, uploaded 18 June 2014]   |  

Abstract

The 1H-pyrazole-3-carboxylic acid 2 was converted in good yield (69%) into the corresponding 1H-pyrazole-3-carboxamide 5 via reaction of the acid chloride 3 with 2,3- diaminopyridine (4). A different product, the 3H-imidazo[4,5-b] pyridine derivative 6, was formed from the reaction of 3 with 4 and base in benzene for 5 hours. The structures of the synthesized compounds were determined spectroscopically. The mechanism of the reaction between 3 and 4 was examined theoretically.
Keywords: furan-2; 3-dione; pyrazole-3-carboxylic acid; pyrazole-3-carboxylic acid chloride; imidazo [4; 5-b]pyridine; IR and NMR spectra; MO calculations. furan-2; 3-dione; pyrazole-3-carboxylic acid; pyrazole-3-carboxylic acid chloride; imidazo [4; 5-b]pyridine; IR and NMR spectra; MO calculations.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yıldırım, I.; Kandemirli, F.; Demir, E. Experimental and Theoretical Studies on the Functionalization Reactions of 4-Benzoyl-1,5-Diphenyl-1H-Pyrazole-3-Carboxylic Acid and Acid Chloride with 2,3-Diaminopyridine. Molecules 2005, 10, 559-571.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top