Next Article in Journal
Previous Article in Journal
Molecules 2005, 10(2), 407-416; doi:10.3390/10020407
Article

Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines

1, 1 and 2,*
Received: 17 February 2004; in revised form: 10 October 2004 / Accepted: 13 October 2004 / Published: 28 February 2005
Download PDF [85 KB, uploaded 18 June 2014]
Abstract: A series of 1-aryl substituted dihydro-, 5-methyldihydro- and 6-methyl-dihydro-2,4(1H,3H)pyrimidinediones and their 2-thio analogues were obtained byreaction of the corresponding β-alanines or α-methyl- and β-methyl-β-alanines with ureaor potassium thiocyanate. The reaction of N-(2,3- and 3,5-dimethylphenyl)-α-methyl-β-alanines with ethyl acetoacetate gave 1-(2,3- or 3,5-dimethylphenyl)-2,5-dimethyl-1,4,5,6-tetrahydro-4(1H)pyridones. The combined spectral data obtained by 1H-, 13C-,1 H/13C (HETCOR) NMR and IR provided useful information about the structure of theproducts synthesized in this work.
Keywords: N-Aryl-β-alanines; 1-aryl substituted dihydropyrimidinedione; dihydro- pyrimidinone-2-thione; 1; 4; 5; 6-tetrahydropyridone; NMR spectra; IR spectra N-Aryl-β-alanines; 1-aryl substituted dihydropyrimidinedione; dihydro- pyrimidinone-2-thione; 1; 4; 5; 6-tetrahydropyridone; NMR spectra; IR spectra
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Vaickelioniene, R.; Mickevicius, V.; Mikulskiene, G. Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines. Molecules 2005, 10, 407-416.

AMA Style

Vaickelioniene R, Mickevicius V, Mikulskiene G. Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines. Molecules. 2005; 10(2):407-416.

Chicago/Turabian Style

Vaickelioniene, Rita; Mickevicius, Vytautas; Mikulskiene, Gema. 2005. "Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines." Molecules 10, no. 2: 407-416.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert