A Comparison of Microwave-Accelerated and Conventionally Heated Iodination Reactions of Some Arenes and Heteroarenes, Using ortho-Periodic Acid as the Oxidant†

doi:10.3390/10020401

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Molecules 2005, 10(2), 401-406; doi:10.3390/10020401

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A Comparison of Microwave-Accelerated and Conventionally Heated Iodination Reactions of Some Arenes and Heteroarenes, Using ortho-Periodic Acid as the Oxidant†

Maciej Sosnowski and Lech Skulski*

Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University, 1 Banacha Street, PL 02-097 Warsaw, Poland

* Author to whom correspondence should be addressed.

Received: 8 November 2004; in revised form: 18 November 2004 / Accepted: 18 November 2004 / Published: 28 February 2005

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Abstract: A fast and simple method for the oxidative iodination of some activated arenes and heteroarenes, either under microwave irradiation or by conventional heating, is reported, using diiodine and ortho-periodic acid as the oxidant. The reactions were carried out in hot 95% ethanol under a reflux condenser. For the microwave assisted reactions, the reaction times were always notably shortened, but the yields were nearly the same as those afforded by the conventional method.

Keywords: Oxidation; ortho-periodic acid as oxidant; oxidative iodination of activated arenes and heteroarenes; diiodine; microwave irradiation

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MDPI and ACS Style

Sosnowski, M.; Skulski, L. A Comparison of Microwave-Accelerated and Conventionally Heated Iodination Reactions of Some Arenes and Heteroarenes, Using ortho-Periodic Acid as the Oxidant†. Molecules 2005, 10, 401-406.

AMA Style

Sosnowski M, Skulski L. A Comparison of Microwave-Accelerated and Conventionally Heated Iodination Reactions of Some Arenes and Heteroarenes, Using ortho-Periodic Acid as the Oxidant†. Molecules. 2005; 10(2):401-406.

Chicago/Turabian Style

Sosnowski, Maciej; Skulski, Lech. 2005. "A Comparison of Microwave-Accelerated and Conventionally Heated Iodination Reactions of Some Arenes and Heteroarenes, Using ortho-Periodic Acid as the Oxidant†." Molecules 10, no. 2: 401-406.

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