Next Article in Journal
Alumina and Silica Oxides as Catalysts for the Oxidation of Benzoins to Benzils under Solvent-free Conditions
Previous Article in Journal
A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
Molecules 2005, 10(10), 1358-1363; doi:10.3390/10101385
Article

Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator

1,* , 1 and 2
1 Department of Chemistry, Yasouj University, Yasouj 75914-353, Iran 2 Department of Chemistry, Isfahan University, Isfahan 81745-117, Iran
* Author to whom correspondence should be addressed.
Received: 12 July 2005 / Revised: 21 July 2005 / Accepted: 22 July 2005 / Published: 31 October 2005
Download PDF [107 KB, uploaded 18 June 2014]

Abstract

Urea-hydrogen peroxide (UHP) was used in the presence of maleic anhydride as mediator in a simple and convenient method for the oxidation in high yield of some thiols to the corresponding disulfides. Peroxymaleic acid formed in situ from the reaction of UHP with maleic anhydride has a key role in this oxidation. Performance of the reaction in various solvents showed that methanol was the solvent of choice at 0 oC. The products were isolated by simple filtration on silica gel.
Keywords: UHP; thiols; disulfides; oxidation. UHP; thiols; disulfides; oxidation.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Karami, B.; Montazerozohori, M.; Habibi, M.H. Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator. Molecules 2005, 10, 1358-1363.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert