Molecules 2005, 10(10), 1358-1363; doi:10.3390/10101385
Article

Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator

1,* email, 1 and 2
Received: 12 July 2005; in revised form: 21 July 2005 / Accepted: 22 July 2005 / Published: 31 October 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Urea-hydrogen peroxide (UHP) was used in the presence of maleic anhydride as mediator in a simple and convenient method for the oxidation in high yield of some thiols to the corresponding disulfides. Peroxymaleic acid formed in situ from the reaction of UHP with maleic anhydride has a key role in this oxidation. Performance of the reaction in various solvents showed that methanol was the solvent of choice at 0 oC. The products were isolated by simple filtration on silica gel.
Keywords: UHP; thiols; disulfides; oxidation.
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MDPI and ACS Style

Karami, B.; Montazerozohori, M.; Habibi, M.H. Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator. Molecules 2005, 10, 1358-1363.

AMA Style

Karami B, Montazerozohori M, Habibi MH. Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator. Molecules. 2005; 10(10):1358-1363.

Chicago/Turabian Style

Karami, Bahador; Montazerozohori, M.; Habibi, M. H. 2005. "Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator." Molecules 10, no. 10: 1358-1363.

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