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Molecules 2005, 10(10), 1358-1363; doi:10.3390/10101385

Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator

Department of Chemistry, Yasouj University, Yasouj 75914-353, Iran
Department of Chemistry, Isfahan University, Isfahan 81745-117, Iran
Author to whom correspondence should be addressed.
Received: 12 July 2005 / Revised: 21 July 2005 / Accepted: 22 July 2005 / Published: 31 October 2005
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Urea-hydrogen peroxide (UHP) was used in the presence of maleic anhydride as mediator in a simple and convenient method for the oxidation in high yield of some thiols to the corresponding disulfides. Peroxymaleic acid formed in situ from the reaction of UHP with maleic anhydride has a key role in this oxidation. Performance of the reaction in various solvents showed that methanol was the solvent of choice at 0 oC. The products were isolated by simple filtration on silica gel. View Full-Text
Keywords: UHP; thiols; disulfides; oxidation. UHP; thiols; disulfides; oxidation.

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MDPI and ACS Style

Karami, B.; Montazerozohori, M.; Habibi, M.H. Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator. Molecules 2005, 10, 1358-1363.

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