Molecules 2005, 10(10), 1351-1357; doi:10.3390/10101351
Article

A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation

Research and Development Center for Fine Chemicals, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P. R. China
* Author to whom correspondence should be addressed.
Received: 6 July 2005; in revised form: 15 August 2005 / Accepted: 17 August 2005 / Published: 31 October 2005
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Abstract: A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.
Keywords: 2-Cyanoacrylate; aromatic amine; aminopyridine; microwave irradiation.

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MDPI and ACS Style

Ouyang, G.; Song, B.; Zhang, H.; Yang, S.; Jin, L.; Li, Q.; Hu, D. A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation. Molecules 2005, 10, 1351-1357.

AMA Style

Ouyang G, Song B, Zhang H, Yang S, Jin L, Li Q, Hu D. A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation. Molecules. 2005; 10(10):1351-1357.

Chicago/Turabian Style

Ouyang, Guiping; Song, Baoan; Zhang, Huiping; Yang, Song; Jin, Linhong; Li, Qianzhu; Hu, Deyu. 2005. "A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation." Molecules 10, no. 10: 1351-1357.

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