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Molecules 2005, 10(10), 1351-1357; doi:10.3390/10101351

A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation

, * , , , ,  and
Research and Development Center for Fine Chemicals, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P. R. China
* Author to whom correspondence should be addressed.
Received: 6 July 2005 / Revised: 15 August 2005 / Accepted: 17 August 2005 / Published: 31 October 2005
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A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.
Keywords: 2-Cyanoacrylate; aromatic amine; aminopyridine; microwave irradiation. 2-Cyanoacrylate; aromatic amine; aminopyridine; microwave irradiation.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ouyang, G.; Song, B.; Zhang, H.; Yang, S.; Jin, L.; Li, Q.; Hu, D. A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation. Molecules 2005, 10, 1351-1357.

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