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Molecules 2005, 10(10), 1318-1324; doi:10.3390/10101318

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

1, 2, 1 and 1,*
1 Laboratory of Pharmaceutical Organic Chemistry, CNRS UMR 6517, University of the Méditerranée. (Aix – Marseille 2), Faculty of Pharmacy, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France 2 Sanofi-Synthélabo Recherche, Sanofi-Aventis, Central Nervous System Research Department, 31 Avenue Paul Vaillant Couturier, 92220 Bagneux, France
* Author to whom correspondence should be addressed.
Received: 6 June 2005 / Revised: 30 August 2005 / Accepted: 30 August 2005 / Published: 31 October 2005
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Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields.
Keywords: Nitro reduction; cyclization; bicyclic 2-pyridones; imidazopyridines; thiazolopyridines. Nitro reduction; cyclization; bicyclic 2-pyridones; imidazopyridines; thiazolopyridines.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Crozet, M.D.; George, P.; Crozet, M.P.; Vanelle, P. Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones. Molecules 2005, 10, 1318-1324.

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