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Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones
Laboratory of Pharmaceutical Organic Chemistry, CNRS UMR 6517, University of the Méditerranée.
(Aix – Marseille 2), Faculty of Pharmacy, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
Sanofi-Synthélabo Recherche, Sanofi-Aventis, Central Nervous System Research Department, 31 Avenue Paul Vaillant Couturier, 92220 Bagneux, France
* Author to whom correspondence should be addressed.
Received: 6 June 2005; in revised form: 30 August 2005 / Accepted: 30 August 2005 / Published: 31 October 2005
Abstract: Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields.
Keywords: Nitro reduction; cyclization; bicyclic 2-pyridones; imidazopyridines; thiazolopyridines.
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Crozet, M.D.; George, P.; Crozet, M.P.; Vanelle, P. Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones. Molecules 2005, 10, 1318-1324.
Crozet MD, George P, Crozet MP, Vanelle P. Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones. Molecules. 2005; 10(10):1318-1324.
Crozet, Maxime D.; George, Pascal; Crozet, Michel P.; Vanelle, Patrice. 2005. "Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones." Molecules 10, no. 10: 1318-1324.