Molecules 2005, 10(10), 1318-1324; doi:10.3390/10101318

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

1, 2, 1 and 1,*
Received: 6 June 2005; in revised form: 30 August 2005 / Accepted: 30 August 2005 / Published: 31 October 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are reported. These reactions afforded the target bicyclic 2-pyridones in good to excellent yields.
Keywords: Nitro reduction; cyclization; bicyclic 2-pyridones; imidazopyridines; thiazolopyridines.
PDF Full-text Download PDF Full-Text [52 KB, uploaded 18 June 2014 19:27 CEST]

Export to BibTeX |

MDPI and ACS Style

Crozet, M.D.; George, P.; Crozet, M.P.; Vanelle, P. Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones. Molecules 2005, 10, 1318-1324.

AMA Style

Crozet MD, George P, Crozet MP, Vanelle P. Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones. Molecules. 2005; 10(10):1318-1324.

Chicago/Turabian Style

Crozet, Maxime D.; George, Pascal; Crozet, Michel P.; Vanelle, Patrice. 2005. "Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones." Molecules 10, no. 10: 1318-1324.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert