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Covalent Polymer-Drug Conjugates
Institute of Polymer Science and Technology (CSIC), Spain
Institute of Industrial Fermentations (CSIC), Spain
* Author to whom correspondence should be addressed.
Received: 13 April 2004; Accepted: 23 June 2004 / Published: 31 January 2005
Abstract: In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised attending to their chemical conjugation. Namely, the classification of this type of DDS is based on the conjugation sites of the reactive groups (i.e., via end groups or pendant polymer groups). Advantages and limitations of these types of DDS are discussed through representative examples of polymer-drugs and polymer-proteins conjugates recently developed.
Keywords: drug delivery system; DDS; polymer-drug; polymer-protein; conjugates
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Elvira, C.; Gallardo, A.; Roman, J.; Cifuentes, A. Covalent Polymer-Drug Conjugates. Molecules 2005, 10, 114-125.
Elvira C, Gallardo A, Roman J, Cifuentes A. Covalent Polymer-Drug Conjugates. Molecules. 2005; 10(1):114-125.
Elvira, C.; Gallardo, A.; Roman, J.; Cifuentes, A. 2005. "Covalent Polymer-Drug Conjugates." Molecules 10, no. 1: 114-125.