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Molecules 2005, 10(1), 114-125; doi:10.3390/10010114
Review

Covalent Polymer-Drug Conjugates

1,* , 1, 1 and 2
1 Institute of Polymer Science and Technology (CSIC), Spain 2 Institute of Industrial Fermentations (CSIC), Spain
* Author to whom correspondence should be addressed.
Received: 13 April 2004 / Accepted: 23 June 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutical Chemistry)
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Abstract

In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised attending to their chemical conjugation. Namely, the classification of this type of DDS is based on the conjugation sites of the reactive groups (i.e., via end groups or pendant polymer groups). Advantages and limitations of these types of DDS are discussed through representative examples of polymer-drugs and polymer-proteins conjugates recently developed.
Keywords: drug delivery system; DDS; polymer-drug; polymer-protein; conjugates drug delivery system; DDS; polymer-drug; polymer-protein; conjugates
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Elvira, C.; Gallardo, A.; Roman, J.; Cifuentes, A. Covalent Polymer-Drug Conjugates. Molecules 2005, 10, 114-125.

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