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Molecules 2005, 10(1), 105-113; doi:10.3390/10010105

AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy

 and *
Laboratoire de Nanotechnologie Pharmaceutique, Faculté de Pharmacie, Université de Montréal, Canada
* Author to whom correspondence should be addressed.
Received: 18 May 2004 / Accepted: 4 July 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutical Chemistry)
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The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.
Keywords: AFM; PLA; Genetic Therapy; Vector; Salen; Schiff base. AFM; PLA; Genetic Therapy; Vector; Salen; Schiff base.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nadeau, V.; Hildgen, P. AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy. Molecules 2005, 10, 105-113.

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