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Molecules 2005, 10(1), 105-113; doi:10.3390/10010105
Article

AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy

 and *
Laboratoire de Nanotechnologie Pharmaceutique, Faculté de Pharmacie, Université de Montréal, Canada
* Author to whom correspondence should be addressed.
Received: 18 May 2004 / Accepted: 4 July 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutical Chemistry)
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Abstract

The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.
Keywords: AFM; PLA; Genetic Therapy; Vector; Salen; Schiff base. AFM; PLA; Genetic Therapy; Vector; Salen; Schiff base.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nadeau, V.; Hildgen, P. AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy. Molecules 2005, 10, 105-113.

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