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AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
Laboratoire de Nanotechnologie Pharmaceutique, Faculté de Pharmacie, Université de Montréal, Canada
* Author to whom correspondence should be addressed.
Received: 18 May 2004; Accepted: 4 July 2004 / Published: 31 January 2005
Abstract: The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.
Keywords: AFM; PLA; Genetic Therapy; Vector; Salen; Schiff base.
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MDPI and ACS Style
Nadeau, V.; Hildgen, P. AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy. Molecules 2005, 10, 105-113.
Nadeau V, Hildgen P. AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy. Molecules. 2005; 10(1):105-113.
Nadeau, V.; Hildgen, P. 2005. "AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy." Molecules 10, no. 1: 105-113.