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Analysis of EEG via Multivariate Empirical Mode Decomposition for Depth of Anesthesia Based on Sample Entropy
School of Mechanical and Electronic Engineering, Wuhan University of Technology, Wuhan 430070, China
School of Information Engineering, Wuhan University of Technology, Wuhan 430070, China
Department of Anesthesiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Department of Anesthesiology, Far Eastern Memorial Hospital, Ban-Chiao 220, Taiwan
School of Engineering and Design, Brunel University, London UB8 3PH, UK
Department of Mechanical Engineering, Yuan Ze University, 135, Yuan-Tung Road, Chung-Li 32003, Taiwan
Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chung-Li 32001, Taiwan
* Author to whom correspondence should be addressed.
Received: 15 July 2013; in revised form: 6 August 2013 / Accepted: 27 August 2013 / Published: 30 August 2013
Abstract: In monitoring the depth of anesthesia (DOA), the electroencephalography (EEG) signals of patients have been utilized during surgeries to diagnose their level of consciousness. Different entropy methods were applied to analyze the EEG signal and measure its complexity, such as spectral entropy, approximate entropy (ApEn) and sample entropy (SampEn). However, as a weak physiological signal, EEG is easily subject to interference from external sources such as the electric power, electric knives and other electrophysiological signal sources, which lead to a reduction in the accuracy of DOA determination. In this study, we adopt the multivariate empirical mode decomposition (MEMD) to decompose and reconstruct the EEG recorded from clinical surgeries according to its best performance among the empirical mode decomposition (EMD), the ensemble EMD (EEMD), and the complementary EEMD (CEEMD) and the MEMD. Moreover, according to the comparison between SampEn and ApEn in measuring DOA, the SampEn is a practical and efficient method to monitor the DOA during surgeries at real time.
Keywords: electroencephalograph; sample entropy; multivariate empirical mode decomposition; depth of anesthesia
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Cite This Article
MDPI and ACS Style
Wei, Q.; Liu, Q.; Fan, S.-Z.; Lu, C.-W.; Lin, T.-Y.; Abbod, M.F.; Shieh, J.-S. Analysis of EEG via Multivariate Empirical Mode Decomposition for Depth of Anesthesia Based on Sample Entropy. Entropy 2013, 15, 3458-3470.
Wei Q, Liu Q, Fan S-Z, Lu C-W, Lin T-Y, Abbod MF, Shieh J-S. Analysis of EEG via Multivariate Empirical Mode Decomposition for Depth of Anesthesia Based on Sample Entropy. Entropy. 2013; 15(9):3458-3470.
Wei, Qin; Liu, Quan; Fan, Shou-Zhen; Lu, Cheng-Wei; Lin, Tzu-Yu; Abbod, Maysam F.; Shieh, Jiann-Shing. 2013. "Analysis of EEG via Multivariate Empirical Mode Decomposition for Depth of Anesthesia Based on Sample Entropy." Entropy 15, no. 9: 3458-3470.