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Impaired Sulfate Metabolism and Epigenetics: Is There a Link in Autism?
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge 02139, MA, USA
* Author to whom correspondence should be addressed.
Received: 28 September 2012; in revised form: 16 October 2012 / Accepted: 16 October 2012 / Published: 18 October 2012
Abstract: Autism is a brain disorder involving social, memory, and learning deficits, that normally develops prenatally or early in childhood. Frustratingly, many research dollars have as yet failed to identify the cause of autism. While twin concordance studies indicate a strong genetic component, the alarming rise in the incidence of autism in the last three decades suggests that environmental factors play a key role as well. This dichotomy can be easily explained if we invoke a heritable epigenetic effect as the primary factor. Researchers are just beginning to realize the huge significance of epigenetic effects taking place during gestation in influencing the phenotypical expression. Here, we propose the novel hypothesis that sulfates deficiency in both the mother and the child, brought on mainly by excess exposure to environmental toxins and inadequate sunlight exposure to the skin, leads to widespread hypomethylation in the fetal brain with devastating consequences. We show that many seemingly disparate observations regarding serum markers, neuronal pathologies, and nutritional deficiencies associated with autism can be integrated to support our hypothesis.
Keywords: autism; epigenetics; cholesterol sulfate; DNA methylation; sulfotransferases; heparan sulfate; folate; cobalamin; zinc
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MDPI and ACS Style
Hartzell, S.; Seneff, S. Impaired Sulfate Metabolism and Epigenetics: Is There a Link in Autism? Entropy 2012, 14, 1953-1977.
Hartzell S, Seneff S. Impaired Sulfate Metabolism and Epigenetics: Is There a Link in Autism? Entropy. 2012; 14(10):1953-1977.
Hartzell, Samantha; Seneff, Stephanie. 2012. "Impaired Sulfate Metabolism and Epigenetics: Is There a Link in Autism?" Entropy 14, no. 10: 1953-1977.