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Good Clinical Practice in Aortic Valve Surgery
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Good Clinical Practice in Aortic Valve Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 1553

Special Issue Editor

Dr. Fabrizio Ceresa

E-Mail Website
Guest Editor
Division of Cardiac Surgery, Department of Cardio-Thoraco-Vascular Surgery, Papardo Hospital, Messina, Italy
Interests: cardiac; aorta surgery; aortic valve; coronary artery bypass grafting; coronary disease; mitral valve surgery; minimally invasive cardiac surgery

Special Issue Information

Dear Colleagues,

Aortic valve disease, the focus of this Special Issue, is one of the most common valve disorders as a consequence of the progressive aging of the population worldwide.

In the most cases, the surgery remains the gold standard in the treatment of both aortic valve stenosis and regurgitation. Technological and tissue engineering research has led to development of new prosthesis and devices both for surgery and transcatheter therapies.

In recent years, minimally invasive techniques for aortic valve repair or replacement have shown exciting early and late outcomes.

This Special Issue will focus on innovative research in aortic valve management, based on a custom-made treatment in the clinical practice, paying particular attention to the mechanism and factor involved in the prognosis of these patients, such as early diagnosis with several imaging modalities, the risk stratification, the optimal timing for intervention and the type of procedure to offer.

Thus, I invite colleagues to submit their original research and communications as well as systemic reviews and meta-analyses on the following topics:

Minimally invasive aortic valve surgery;
Trans-catheter aortic valve replacement;
Aortic valve repair techniques;
New tissue valves, especially in younger patients.

Case series and case reports will be only considered if of particular interest.

Dr. Fabrizio Ceresa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aortic valve replacement
  • aortic valve repair
  • trans-catheter aortic valve replacement
  • minimally invasive surgery
  • prognostic scores
  • point of care

Published Papers (3 papers)

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10 pages, 653 KiB  
Article
Surgical Aortic Valve Replacement and Renal Dysfunction: From Acute Kidney Injury to Chronic Disease
by Antonio Lacquaniti, Fabrizio Ceresa, Susanna Campo, Antonella Smeriglio, Domenico Trombetta, Francesco Patanè and Paolo Monardo
J. Clin. Med. 2024, 13(10), 2933; https://doi.org/10.3390/jcm13102933 - 16 May 2024
Viewed by 405
Abstract
Background: Surgical aortic valve replacement (SAVR) is often complicated by acute kidney injury (AKI). Identifying patients at risk of AKI is important to start nephroprotective strategies or renal replacement therapy (RRT). This study investigated the incidence and risk factors of post-operative AKI in [...] Read more.
Background: Surgical aortic valve replacement (SAVR) is often complicated by acute kidney injury (AKI). Identifying patients at risk of AKI is important to start nephroprotective strategies or renal replacement therapy (RRT). This study investigated the incidence and risk factors of post-operative AKI in SAVR patients. Chronic kidney disease (CKD) developed in the post-cardiac-surgery follow-up period was also assessed. Methods: A total of 462 SAVR patients were retrospectively enrolled. The primary endpoint was the occurrence rate of AKI after surgery. Kidney recovery, during two planned outpatient clinic nephrological visits within 12 months after the surgery, was assessed. Results: A total of 76 patients experienced an AKI event. A Kaplan–Meier analysis revealed that subjects with CKD stage IV had a time to progression of 2.7 days, compared to patients with stages I–II, who were characterized by the slowest progression time, >11.2 days. A Cox regression indicated that CKD stages predicted a higher risk of AKI independently of other variables. During their ICU stay, 23 patients died, representing 5% of the population, most of them requiring RRT during their ICU stay. A severe CKD before the surgery was closely related to perioperative mortality. During the follow-up period, 21 patients with AKI worsened their CKD stage. Conclusions: AKI represents a common complication for SAVR patients in the early post-operative period, prolonging their ICU stay, with negative effects on survival, especially if RRT was required. Pre-operative CKD >3 stage is an independent risk factor for AKI in patients undergoing SAVR. Full article
(This article belongs to the Special Issue Good Clinical Practice in Aortic Valve Surgery)
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9 pages, 224 KiB  
Article
Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity
by Tomo Svaguša, Marko Žarak, Dubravka Šušnjar, Savica Gjorgjievska, Josip Varvodić, Nikola Slišković, Gloria Šestan, Marko Kušurin, Ingrid Prkačin and Igor Rudež
J. Clin. Med. 2024, 13(9), 2472; https://doi.org/10.3390/jcm13092472 - 24 Apr 2024
Viewed by 495
Abstract
Background: It has recently been shown that cardiac-specific troponin I concentrations in first morning urine samples can be measured with commercially available tests. Due to their accumulation in the first morning urine, scientific papers indicate a potential predictive value for cardiovascular diseases. [...] Read more.
Background: It has recently been shown that cardiac-specific troponin I concentrations in first morning urine samples can be measured with commercially available tests. Due to their accumulation in the first morning urine, scientific papers indicate a potential predictive value for cardiovascular diseases. Therefore, the aim of this study was to compare the concentration of cardiac troponin I in the first morning urine in patients with severe aortic stenosis and the healthy population. Patients and Methods: Blood and first morning urine samples were collected from 34 healthy individuals (17 female) at University Hospital Merkur and 25 patients with severe aortic stenosis (14 female) before surgical treatment at University Hospital Dubrava. Cardiac troponin I and T values were determined using high-sensitivity assays using commercially available Abbott and Roche tests. Results: Patients with severe aortic stenosis had significantly lower troponin I concentrations in the first morning urine samples (0.3 ng/L (0.1–0.6)) as compared to the healthy population (15.2 ng/L (8.4–19.9)) (p < 0.001). There was no statistically significant difference in troponin T concentrations between healthy individuals and patients with severe aortic stenosis. In parallel, both I and T plasma troponin concentrations were significantly higher in patients with severe aortic stenosis. Conclusions: In patients with severe aortic stenosis, cardiac troponin I values in the first morning urine are significantly lower than in healthy subjects. Full article
(This article belongs to the Special Issue Good Clinical Practice in Aortic Valve Surgery)

Other

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10 pages, 1251 KiB  
Systematic Review
Percutaneous Coronary Intervention before or after Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis Involving 1531 Patients
by Rodolfo Caminiti, Alfonso Ielasi, Giampaolo Vetta, Antonio Parlavecchio, Domenico Giovanni Della Rocca, Dario Pellegrini, Mariano Pellicano, Carolina Montonati, Nastasia Mancini, Gabriele Carciotto, Manuela Ajello, Giustina Iuvara, Francesco Costa, Giulia Laterra, Marco Barbanti, Fabrizio Ceresa, Francesco Patanè, Antonio Micari and Giampiero Vizzari
J. Clin. Med. 2024, 13(12), 3521; https://doi.org/10.3390/jcm13123521 - 16 Jun 2024
Viewed by 349
Abstract
Background: The optimal timing to perform percutaneous coronary interventions (PCIs) in patients undergoing transcatheter aortic valve replacement (TAVR) is not well established. In this meta-analysis, we aimed to compare the outcomes of patients undergoing PCI before versus after TAVR. Methods: A comprehensive literature [...] Read more.
Background: The optimal timing to perform percutaneous coronary interventions (PCIs) in patients undergoing transcatheter aortic valve replacement (TAVR) is not well established. In this meta-analysis, we aimed to compare the outcomes of patients undergoing PCI before versus after TAVR. Methods: A comprehensive literature search was performed including Medline, Embase, and Cochrane electronic databases up to 5 April 2024 for studies that compared PCI before and after TAVR reporting at least one clinical outcome of interest (PROSPERO ID: CRD42023470417). The analyzed outcomes were mortality, stroke, and myocardial infarction (MI) at follow-up. Results: A total of 3 studies involving 1531 patients (pre-TAVR PCI n = 1240; post-TAVR PCI n = 291) were included in this meta-analysis following our inclusion criteria. Mortality was higher in the pre-TAVR PCI group (OR: 2.48; 95% CI: 1.19–5.20; p = 0.02). No differences were found between PCI before and after TAVR for the risk of stroke (OR: 3.58; 95% CI: 0.70–18.15; p = 0.12) and MI (OR: 0.66; 95% CI: 0.30–1.42; p = 0.29). Conclusions: This meta-analysis showed in patients with stable CAD undergoing TAVR that PCI after TAVR is associated with lower mortality compared with PCI before TAVR. Full article
(This article belongs to the Special Issue Good Clinical Practice in Aortic Valve Surgery)
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