Reprint

Precision Medicine in Neurodevelopmental Disorders

Personalized Characterization of Autism from Molecules to Behavior

Edited by
August 2022
184 pages
  • ISBN978-3-0365-5127-2 (Hardback)
  • ISBN978-3-0365-5128-9 (PDF)

This book is a reprint of the Special Issue Precision Medicine in Neurodevelopmental Disorders: Personalized Characterization of Autism from Molecules to Behavior that was published in

Medicine & Pharmacology
Public Health & Healthcare
Summary

This book focuses on the proposition of a paradigm shift to enable stratification of the highly heterogeneous autism spectrum disorders, by borrowing from and adapting the precision medicine model. A compilation of 9 rigorously peer-reviewed manuscripts offers new approaches to automatically stratify autism-related genes into different neuropsychiatric and associated neurological disorders and, accordingly, repurpose existing therapies and support systems for each thus uncovered phenotypic subtype. Methods for telemedicine are introduced to scale diagnostics and brought to underrepresented communities, thus diversifying the pool of participants in research and treatments. Biosensor data and methods are introduced to accompany genomics subtyping with precision phenotyping. Importantly, an in-depth review offering a paradigm shift for early detection and treatments of autism is presented through stages of neurodevelopment spanning from the womb to infancy and beyond, across the human lifespan.

Format
  • Hardback
License
© by the authors
Keywords
embodied cognition; agency; action ownership; network analysis; graph theory; motor control; voluntary motion; precision medicine; crowdsourcing; machine learning; diagnostics; telemedicine; autism; pediatrics; autism; schizophrenia; mental depression; ataxia; fragile X; Parkinson’s disease; mitochondria; gene expression; tissues; neurological disorders; nervous systems disorders; children; adult; difficulties; disorders; coordination; focus; Autism Spectrum Disorder (ASD); pathogenesis; prevention; epigenetics; immune activation; gut dysbiosis; mitochondrial impairment; oxidative stress; metabolomics; machine learning; EEG; pain biometrics; stochastic analyses; micro-movements spikes; sensory over responsivity; standardized scale; personalized pain; autism spectrum disorder; screening; diagnosis; artificial intelligence; machine learning; Autism; genes; tissues; stratification; neurodevelopment; neurological disorders; neuropsychiatric disorders; n/a