New Advances in Melanoma

Edited by
March 2022
148 pages
  • ISBN978-3-0365-3453-4 (Hardback)
  • ISBN978-3-0365-3454-1 (PDF)

This book is a reprint of the Special Issue New Advances in Melanoma that was published in

Medicine & Pharmacology
Public Health & Healthcare

Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metastatic potential of this tumor, melanoma prognosis has been quite poor for a long time. In the past decade, groundbreaking discoveries in the melanoma research field have led to the development of two main treatment strategies: combination therapies targeting specific kinases or combination therapies focused on immune checkpoint inhibitors (ICIs). These treatment approaches have become the standard of care in most cancer centers and significantly improved the prognosis and overall survival of advanced melanoma patients. Nevertheless, many patients do not benefit from or even respond to these treatments. It is therefore essential to better comprehend the phenomenon of drug resistance, immune escape mechanisms, as well as to search for alternative treatment strategies. In addition, strong predictive biomarkers are desperately needed to improve clinical efficacy. The aim of this Special Issue is to present recent advances in the field of melanoma research, in which the abovementioned areas represent the primary focus, and other relevant themes are also discussed.

  • Hardback
© 2022 by the authors; CC BY-NC-ND license
melanoma; targeted therapies; BRAF; druggable mutations; real-time PCR; NGS assay; immune escape; microRNA; melanoma; transporter associated with antigen processing; melanoma; incidence; population-based study; epidemiology; Spain; skin cancer; melanoma; single-cell transcriptome sequencing; treatment response; pseudotime analysis; melanoma; treatment; ubiquitination; miRNAs; melanoma; embryogenesis; melanoblasts; melanoblast; melanoma; NF1; transcriptome; RNAseq; Trp-1; metastasis; melanoma; animal models; lung; mice