<em>Bacillus thuringiensis</em> Toxins: Functional Characterization and Mechanism of Action

Edited by
November 2021
340 pages
  • ISBN978-3-0365-2049-0 (Hardback)
  • ISBN978-3-0365-2050-6 (PDF)

This book is a reprint of the Special Issue Bacillus thuringiensis Toxins: Functional Characterization and Mechanism of Action that was published in

Biology & Life Sciences
Medicine & Pharmacology
Public Health & Healthcare

Bacillus thuringiensis (Bt)-based products are the most successful microbial insecticides to date. This entomopathogenic bacterium produces different kinds of proteins whose specific toxicity has been shown against a wide range of insect orders, nematodes, mites, protozoa, and human cancer cells. Some of these proteins are accumulated in parasporal crystals during the sporulation phase (Cry and Cyt proteins), whereas other proteins are secreted in the vegetative phase of growth (Vip and Sip toxins). Currently, insecticidal proteins belonging to different groups (Cry and Vip3 proteins) are widely used to control insect pests and vectors both in formulated sprays and in transgenic crops (the so-called Bt crops). Despite the extensive use of these proteins in insect pest control, especially Cry and Vip3, their mode of action is not completely understood.

The aim of this Special Issue was to gather information that could summarize (in the form of review papers) or expand (research papers) the knowledge of the structure and function of Bt proteins, as well as shed light on their mode of action, especially regarding the insect receptors. This subject has generated great interest, and this interest has been materialized into the 18 papers of important scientific value in the field (5 reviews and 13 research papers) that have been compiled in this issue.

  • Hardback
© 2022 by the authors; CC BY-NC-ND license
Bacillus thuringiensis; Plutella xylostella; Cry1Ac resistance; trypsin-like midgut protease; protoxin activation; Bacillus thuringiensis; Spodoptera spp., Helicoverpa armigera; Mamestra brassicae; Anticarsia gemmatalis; Ostrinia furnacalis; Cry2Ab toxin; Bombyx mori; ATP-binding cassette subfamily a member 2 (ABCA2); genome editing; transcription activator-like effector-nucleases (TALENs); HEK293T cell; functional receptor; Vip3Aa; lysosome; mitochondria; apoptosis; Sf9 cells; Cry1Ab; oligomer formation; Sf21 cell line; Ostrinia nubilalis; Lobesia botrana; Leptinotarsa decemlineata; bioassay; Cyt2Aa2 toxin; protein-lipid binding; erythrocyte membrane; AFM; QCM-D; Asian corn borer; ABCC2; CRISPR/Cas9; Cry1Fa; resistance; Bacillus thuringiensis; chitin-binding protein; adhesion; peritrophic matrix; Bacillus thuringiensis; Vip3A; Spodoptera litura; site-directed mutagenesis; Bacillus thuringiensis; Cry; Cyt; parasporins; S-layer proteins; Vip; Sip; membrane receptors; insecticidal activity; anticancer activity; Bacillus thuringiensis; Aedes aegypti; minor proteins; synergy; mosquito control; Bti; Bacillus thuringiensis; Spodoptera frugiperda; cadherin; Cry1Ab; Cry1Fa; mode of action of Cry toxin; Bacillus thuringiensis; insecticidal proteins; insect resistance; tobacco budworm; Bacillus thuringiensis proteins; coleopteran pests; insecticidal activity; structure; mode of action; Bacillus thuringiensis; Vip3A; 3D-structure; mode of action; biological control; Bacillus thuringiensis; antimicrobial peptide; gut microbiota; Bacillus thuringiensis; vegetative insecticidal proteins; insecticidal activity; resistance; pyramids; 3D-Cry toxins; in vitro evolution; rational design; Bacillus thuringiensis; toxin enhancement; n/a; n/a; n/a