Juvenile Onset Huntington's Disease

Edited by
January 2021
102 pages
  • ISBN978-3-03943-811-2 (Hardback)
  • ISBN978-3-03943-812-9 (PDF)

This book is a reprint of the Special Issue Juvenile Onset Huntington's Disease that was published in

Biology & Life Sciences
Computer Science & Mathematics
Medicine & Pharmacology
Public Health & Healthcare
The Special Issue “Juvenile Onset Huntington’s Disease” highlights the growing interest in understanding the unique aspects of this ultra-rare disorder. After decades of research, gene therapy trials are underway for Adult Onset Huntington’s Disease (AOHD). However, patients with Juvenile Onset Huntington’s Disease (JOHD) are often excluded from these efforts, leaving many questions regarding its phenomenology. The current issue includes seven articles spanning work on the difficult emotional experiences of parents of children with JOHD; a review of the clinical manifestations of JOHD; behavioral issues in JOHD; CAG repeat and age of motor onset; autonomic nervous system dysfunction; and abnormality in MRI metabolic markers. Finally, a review of the therapeutic advances is included, highlighting future possibilities of clinical trials in JOHD subjects. The HD community—patients, family members at-risk for HD, caregivers, health-care professionals and scientists—is keen on expanding our understanding of JOHD. In the flurry of research on AOHD, those with JOHD were seemingly ‘left behind.’ The study of patients who are afflicted early in life with HD has become imperative, with this Special Issue representing just the beginning of the required effort to address this urgent need.
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Huntington’s disease; CAG repeat; mutant huntingtin (mHTT); therapeutics; neurodegeneration; juvenile Huntington’s disease; pediatric Huntington’s disease; early-onset Huntington’s disease; personal experiences; caregivers; juvenile Huntington’s disease; pediatric Huntington’s disease; early-onset Huntington’s disease; case series; juvenile-onset Huntington’s disease; T1-Rho; neuroimaging; Huntington’s disease; behavioral regulation; executive function; trinucleotide repeat disorder; CAG; juvenile-onset Huntington’s disease; motor onset; juvenile-onset Huntington’s Disease; autonomic; neurodegeneration; n/a