In-Cell NMR Spectroscopy

Biomolecular Structure and Function

Edited by
April 2020
152 pages
  • ISBN978-3-03928-254-8 (Hardback)
  • ISBN978-3-03928-255-5 (PDF)

This book is a reprint of the Special Issue In-Cell NMR Spectroscopy: Biomolecular Structure and Function that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.]
  • Hardback
License and Copyright
© 2020 by the authors; CC BY-NC-ND license
whole cell NMR; magic-angle spinning; 2D INADEQUATE; crystalline and amorphous starch; in-cell NMR; Tau; MARK2 phosphorylation; mammalian cells; in-cell NMR; protein structure; protein dynamics; drug discovery; target engagement; protein modification; antimicrobial peptide; live cell; solid-state NMR; DNA; lipid membrane; protein NMR; in-cell NMR; in-situ NMR; DNP; review; in-cell NMR; time-resolved NMR; post-translational modifications; structure function; intrinsically disordered proteins; Ribosome; mRNA; rRNA; Thioredoxin; Adenylate kinase; Thymidylate synthase; Dihydrofolate reductase; cross-correlated relaxation; protein interactions; protein structure-function; enzyme activity; enzyme kinetics; NMR spectroscopy; protein structure determination 1; non-uniform sampling 2; spectrum reconstruction 3; structural calculation 4; paramagnetic effects