Major Histocompatibility Complex (MHC) in Health and Disease

Edited by
February 2020
374 pages
  • ISBN978-3-03928-072-8 (Paperback)
  • ISBN978-3-03928-073-5 (PDF)

This book is a reprint of the Special Issue Major Histocompatibility Complex (MHC) in Health and Disease that was published in

Biology & Life Sciences
Medicine & Pharmacology
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
  • Paperback
© 2020 by the authors; CC BY-NC-ND license
MHC-I- and MHC-II-dependent inter-individual recognition; MHC-II-associated sperm-egg recognition; MHC-I-based mother-fetus recognition; giant panda; long-fragment super haplotype; MHC; genetic drift; haplotype; crested ibis; founder effect; bottleneck; conservation genetics; selection; fish; MHC; polymorphism; disease resistance; quantitative trait loci (QTL) studies; evolution; HCP5; lncRNA; MHC; HLA; human endogenous retrovirus (HERV); cancer; autoimmune diseases; competing endogenous RNA (ceRNA); human immunodeficiency virus (HIV); human papillomavirus (HPV); astrogliosis; PNS/CNS interface; microglial reaction; synaptic covering; β2m knockout mice; HLA-B27; viral peptides; computational analysis; ankylosing spondylitis; KIR; KIR–HLA pairs; ethnic populations in China; molecular dynamics simulation; major histocompatibility complex; antigen; T-cell receptor; domain movements; autoimmunity; risk genes; expression; regulation; swine leukocyte antigen; reproductive performance; production trait; haplotype; micro-mini-pigs; disease association; haplotype; HLA polymorphism; major histocompatibility complex (MHC); pedigree; phase; protocol; single nucleotide polymorphism (SNP); T1DGC; type 1 diabetes (T1D); BK virus; polyomavirus; nephropathy; human leukocyte antigen-E; kidney transplantation; MHC; ancestral haplotype; autoimmune disease; cynomolgus macaque; Macaca fascicularis; MHC polymorphism; experimental medicine; nonhuman primate models; DXO; DOM3Z; NELF-E; RD; SKIV2L; SKI2W; STK19; RP1; NSDK; RLR; miR1236; SVA; RNA quality control; 5′→3′ RNA decay; 3′→5′ mRNA turnover; antiviral immunity; interferon β; promoter-proximal transcriptional pause; exosomes; nuclear kinase; hepatocellular carcinoma; Ski complex; trichohepatoenteric syndrome; melanoma; major histocompatibility complex; MHC; evolution; nonclassical; fish; MHC genes; birds; disease resistance; orthology; life history; gene duplication; long-read sequencing; high-throughput sequencing; concerted evolution; ecology; MHC; major histocompatibility complex; Old World camels; camels; dromedary; Bactrian camel; SNP; n/a