Mechanisms of Adiponectin Action

Edited by
July 2019
222 pages
  • ISBN978-3-03921-245-3 (Paperback)
  • ISBN978-3-03921-246-0 (PDF)

This book is a reprint of the Special Issue Mechanisms of Adiponectin Action that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.
  • Paperback
License and Copyright
© 2019 by the authors; CC BY-NC-ND license
adiponectin; atherosclerosis; cholesterol efflux; diabetes; inflammation; endometrium; implantation; transcriptome; microarray; adiponectin; pig; fertility; adipose tissue; reproductive tract; adipokines; cell signaling; skeletal muscle; regeneration; adiponectin isoforms; exercise; training; adiponectin; AMPK; BIAcore; extracellular signal-regulated kinase (ERK); matricellular proteins; neuritogenesis; NGFβ; PC12 cells; Secreted protein; acidic and rich in cysteine (SPARC); adiponectin; muscle; myopathies; adiponectin; metabolism; AdipoRon; lipotoxicity; adiponectin; adiponectin inducer; kojyl cinnamate ester derivative; adipogenesis; hair growth-related factor; human follicular dermal papilla cell; obesity; adipokines; adiponectin; breast cancer; ovarian cancer; endometrial cancer; cervix cancer; estrogen receptor; adiponectin; obesity; cancer; adiponectin; adipose tissue; obesity; endocrine cancer; n/a

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