Reprint

Pleiotropic Action of Selenium in the Prevention and Treatment of Cancer, and Related Diseases

Edited by
March 2019
166 pages
  • ISBN978-3-03897-692-9 (Paperback)
  • ISBN978-3-03897-693-6 (PDF)

This is a Reprint of the Special Issue Pleiotropic Action of Selenium in the Prevention and Treatment of Cancer, and Related Diseases that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary

Gene cloning and sequence has provided the opportunity to identify and characterize the functional role of biomarkers expressed in and on tumor cells and the surrounding microenvironment. Molecular and immunologic heterogeneity of cells in the tumor microenvironment contributes to instability, enhanced angiogenesis, and drug resistance of the tumor cell. Since tumor cells are the ultimate therapeutic targets for drugs and therapy development, the tumor microenvironment that regulates the growth and the delivery of effective drug concentrations to tumor cells is the gatekeeper. Thus, to have a significant impact on the overall survival and cure of patients with advanced cancer, the stabilization of the tumor microenvironment should be the initial treatment, followed by treatment that targets and kills tumor cells.

Antiangeogenic therapies hold considerable promise in the treatment of a subset of cancer patients and are reported to have a significant impact on the stabilization of the tumor microenvironment. More recently, selenium-containing molecules, such as se-metylselenocysteine, seleno-L-methionine, and selenized yeast, among others, have been shown to target and modulate biomarkers associated with tumor cells and the tumor microenvironment. The effects are selenium type-, dose-, and schedule-dependent. The pleiotropic actions of selenium are necessary for tumor cell sensitization, and synergy with mechanism-based combinations. This Special Issue is devoted to highlighting evidence for the potential role of specific types, doses, and schedules of selenium alone and in combination with mechanism-based biologic and cytotoxic therapies for the prevention and treatment of cancer and related diseases. The collection of contributions should provide a comprehensive overview of the pharmacology, metabolism, and delineation of the pleiotropic action of different types of selenium molecules, relevant to the use of selenium as a potential modulator of the therapeutic efficacy and toxicity of biologic and cytotoxic therapies for cancer and related diseases. The pleiotropic action of specific types of selenium, doses, and schedule, as a selective and efficacious modulator of genetic, immunologic, and epigenetic biomarkers, should stimulate expanded preclinical research that could ultimately impact the development of new and novel approaches for the treatment of cancer.
Format
  • Paperback
License and Copyright
© 2019 by the authors; CC BY-NC-ND license
Keywords
selenium; methylselenoesters; entosis; anticancer agent; hypoxia; tumor microenvironment; tumor heterogeneity; cancer; cancer stem cells; EMT; cell plasticity; DNA damage and repair; immune evasion; HIF; selenium; glutathione; malignant; viability; DNA damage; ER stress; methylselenocysteine; seleno-l-methionine; clear-cell renal cell carcinoma microRNAs; hypoxia-inducible factor; antitumor activity; selenium-binding protein 1; SBP1; SELENBP1; hSP56; cancer; disease; clear cell renal cell carcinoma; hypoxia-inducible factors (HIFs); selenium; PD-L1; miRNA; VEGF; mTOR inhibitors; selenium species; Se-containing nanoparticles; anticancer; chemotherapeutics; epigenetics; head and neck cancer; selenium; methylseleninic acid; radiation; lipid peroxidation; glutathione; tocopherol; selenium; isoselenourea; melanoma; STAT3; apoptosis

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