New Strategies in Preventing Inflammatory and/or Oxidative-Stress-Induced Damages in Ischemia–Reperfusion Injury

This Reprint brings together a set of original articles and reviews that explore the multifaceted nature of ischemia–reperfusion injury, a process central to many acute and chronic conditions. The contributions reflect different perspectives—from basic cellular mechanisms to preclinical models and early clinical observations—offering a broad view of how oxidative stress, inflammation, and mitochondrial dysfunction interact in the pathophysiology of reperfusion injury. Several studies focus on antioxidant-based interventions, ranging from classical molecules to newer therapeutic approaches that modulate endogenous defense systems. Others examine biomarkers, imaging tools, or the timing of intervention as key elements in preventing irreversible damage. Rather than presenting definitive conclusions, the articles collected here underline the complexity of the phenomenon and the challenges that remain. This Reprint may be of interest to those working in experimental medicine, surgery, neuroscience, cardiovascular research, and related disciplines, where reperfusion injury remains a major hurdle to improving outcomes.