**Acknowledgments**

We thank F. Hoffmann-La Roche for the gift of Ro 19-8022, and the Research Council of Norway and the Throne Holstfond for financial support. AA thanks the Ministerio de Educación y Ciencia ("Juan de la Cierva" programme, 2009) of the Spanish Government for personal support. We confirm that there are no conflicts of interest. AA and ARC conceived the project and wrote the paper. AA also carried out experiments, with SC, YL and NEB; all authors contributed to analysis and interpretation of results.
