Reprint
Biomimetic Radical Chemistry and Applications
Edited by
March 2020
300 pages
- ISBN978-3-03928-392-7 (Paperback)
- ISBN978-3-03928-393-4 (PDF)
This book is a reprint of the Special Issue Biomimetic Radical Chemistry and Applications that was published in
Chemistry & Materials Science
Medicine & Pharmacology
Summary
The enormous importance of free radical chemistry for a variety of biological events, including ageing and inflammation, has attracted a strong interest in understanding the related mechanistic steps at the molecular level. Modelling the free radical chemical reactivity of biological systems is an important research area. When studying free-radical-based chemical mechanisms, biomimetic chemistry and the design of established biomimetic models come into play to perform experiments in a controlled environment that is suitably designed to be in strict connection with cellular conditions. This Special Issue gives the reader a wide overview of biomimetic radical chemistry, where molecular mechanisms have been defined and molecular libraries of products are developed to also be used as traces for the discovery of some relevant biological processes. Several subjects are presented, with 12 articles and 6 reviews written by specialists in the fields of DNA, proteins, lipids, biotechnological applications, and bioinspired synthesis, having “free radicals” as a common denominator.
Format
- Paperback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
type 2 diabetes; glycogen phosphorylase; anomeric spironucleosides; 1,6-dioxa-4-azaspiro[4.5]decane; [1,5]-radical translocation; DNA; guanine quadruplexes; radicals; electron holes; oxidative damage; photo-ionization; time-resolved spectroscopy; inhomogeneous reactions; radiosensitizers; stationary radiolysis; pulse radiolysis; modified nucleosides; cellular response; liposomal somatostatin; retarded delivery; free radicals; isomerization; trans lipid; peroxidation; photolysis; laser flash photolysis; γ-radiolysis; singlet oxygen; nucleosides; free radicals; reaction mechanism; catalase activity; iron(IV)-oxo; hydrogen peroxide; oxidation; kinetic studies; gold nanoparticles; albumin; EPR spectroscopy; Raman spectroscopy; circular dichroism; beta cells; diabetes; confocal microscopy; lipidomics; membrane fluidity maps; cell micropolarity maps; DNA damage; 5′,8-cyclopurines; 8-oxo-dG; free radicals; pulse radiolysis; gamma radiolysis; Fenton reaction; oligonucleotides; oxidative DNA damage; DNA replication stress; replication fork stalling; genomic and epigenomic instability; DNA methylation; histone modifications; miRNAs; iron porphyrin; heme; ATRPase; iron-mediated ATRP; bio-mimicking catalyst; biomimetic radical reaction; bioinspired chemical catalysis; protein labeling; DNA oxidation; DNA hole transfer; DNA; quantum dynamics; electron transfer; charge transfer; radical reaction; azidoalkylation; carboazidation; sulfones; azides; Julia–Kocienski olefination; DNA damage; copper; chemical nuclease; intercalation; free radical oxidation; protein stability; therapeutic proteins; thiyl radicals; oxidation; fragmentation; cross-link; 2-thiouracil; radiosensitizers; ●OH and ●N3 radicals; 2c-3e S∴S-bonded intermediates; pulse radiolysis; TD-DFT methods; thiobases; nucleobase derivatives; reactive aldehydes; hydroxynonenal; oxononenal; free fatty acids; mitochondrial uncoupling protein; lipid bilayer membranes