Reprint
Adipokines 2.0
Edited by
April 2020
406 pages
- ISBN978-3-03928-586-0 (Paperback)
- ISBN978-3-03928-587-7 (PDF)
This book is a reprint of the Special Issue Adipokines 2.0 that was published in
Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary
Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.
Format
- Paperback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
adipokines; secreted frizzled-related protein 5; leptin; ghrelin; excessive gestational weight gain; neonatal anthropometry; obesity; proteolysis; Tango bioassay; biologic activity; chemerin receptors; excessive gestational weight gain; neonatal anthropometry; leptin; ghrelin; Nonalcoholic fatty liver disease; fatty liver; free fatty acids; label-free proteomic profiling; adipokine; obesity; visceral fat; sick fat; annexins; adipose tissue; adiponectin; cholesterol; glucose homeostasis; inflammation; insulin; lipid metabolism; obesity; triglycerides; adipokine; chemerin; leukocyte; cancer; adipokines; PCOS; polycystic ovary morphology; follicular fluid; human granulosa cells; chemerin; chemerin receptors; hypothalamus; oestrous cycle; early pregnancy; pig; alpha-fetoprotein; liver steatosis; hypertension; adipokines; SGBS adipocytes; glucose restriction; in vitro fat regain; weight regain; complement factors; cathepsins; extracellular remodeling; adipokine; rheumatic diseases; inflammation; osteoarthritis; rheumatoid arthritis; ovary; testis; adipose tissue; polycystic ovary syndrome; preeclempsia; gestational diabetes; testicular pathologies; rheumatoid arthritis; tocilizumab; lipids; adipokines; adiponectin; resistin; leptin; cancer; obesity; adipokine; chemerin; chemokine-like receptor 1; G protein-coupled receptor 1; C-C chemokine receptor-like 2; critical illness; sepsis; adipokines; biomarker; prognosis; ICU; adipokine; adipose-brain axis; brain health; neurodegeneration; depression; energy metabolism; inflammation; hypothalamus; microglia; adiponectin; adipokine; myokine; fitness; metabolically healthy obese; early-life programming; epicardial adipose tissue (EAT); prostaglandin E2 (PGE2); EP3 receptor; EP4 receptor; exchange protein directly activated by cAMP isoform 2 (EPAC2); stimulating growth factor 2 (ST2); interleukin(IL)-33; Cardiovascular Diseases (CVDs); fat mass; n/a