Reprint

Malignant Mesothelioma

Edited by
December 2021
328 pages
  • ISBN978-3-0365-2368-2 (Hardback)
  • ISBN978-3-0365-2367-5 (PDF)

This is a Reprint of the Special Issue Malignant Mesothelioma that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary

Malignant mesothelioma (MM) is a rare and aggressive cancer, related to chronic inflammation and oxidative stress caused mainly by exposure to asbestos. Although this mineral has been banned for decades in many countries, epidemiologists predict the MM epidemic will last past 2040, raising many concerns in public health given its late diagnosis, dismal prognosis, and lack of current efficient therapies.To deal with this situation, important breakthroughs have recently been made in the understanding of MM’s complex biology and the carcinogenic process of the different patterns of the disease. Examples of these include the development of new biomarkers and the deciphering of gene–environment interactions, molecular mechanisms of invasiveness, deregulated pathways, altered expression of miRNAs, DNA damage repair, or metabolic profile. From now on, MM’s aggressive and chemoresistant character appears linked to a polyclonal malignancy, and heterogeneity in molecular alterations.Given these improvements, new therapeutic targets are being explored to solve the double challenge faced by clinicians. The first is to reduce tumor development and its wasting consequences as soon as possible, without resistance and with limited toxicity. The second is to stimulate the recognition of tumor cells by the induction of a specific immune response. This Special Issue will highlight all these aspects.

Format
  • Hardback
License and Copyright
© 2022 by the authors; CC BY-NC-ND license
Keywords
well-differentiated papillary mesothelioma; WDPM; malignant mesothelioma; DNA sequencing; mutation; mesothelioma; tumor suppressor; targeted therapy; immunotherapy; malignant mesothelioma; biomarkers; proteomics; macrophage-capping protein; fatty acid-binding protein; laminin subunit beta-2; selenium-binding protein 1; carcinogenesis; malignant pleural mesothelioma; asbestos exposure; DNA methylation; lymphocyte-to-monocyte ratio; epigenome-wide analysis; survival analysis; metabolomics; mesothelioma; radiotherapy; biomarkers; cancers; malignant pleural mesothelioma; inflammation; infiltrating immune cells; prognostic biomarker; predictive biomarker; immune therapy; malignant mesothelioma; VATS; extrapleural pneumonectomy; pleurectomy decortication; mesothelioma; immunotherapy; therapy response; survival; FDG; PET-CT; malignant pleural mesothelioma; mesothelium; oxidative stress; redox-sensitive factors; asbestos; biomarkers; malignant mesothelioma; carcinogenesis; asbestos exposure; carbon nanotubes; malignant mesothelioma; protein-protein interactions; systems biology; network analysis; drug repurposing; pleural mesothelioma; gene expression; immunogenicity; sarcomatoid; epithelioid; mesothelioma; first line; meta-analysis; systematic review; MPM; lurbinectedin; DNA damage response; mesothelioma; histotype; Hippo pathway; NF2; BAP1; CDKN2A; PTCH1; SETD2; MTAP; malignant pleural mesothelioma; liquid biopsies; circulating tumor DNA; plasma; cancer-specific mutations; genomics; cancer biomarkers; mesothelioma; tumor microenvironment; tumor-associated macrophages; dendritic cells; immunohistochemistry; malignant pleural mesothelioma; asbestos exposure; DNA methylation; epigenome-wide analysis; interaction analysis; malignant pleural mesothelioma; pleural effusion; biomarkers; n/a