Reprint
Mesothelioma Heterogeneity: Potential Mechanisms
Edited by
December 2018
204 pages
- ISBN978-3-03897-473-4 (Paperback)
- ISBN978-3-03897-474-1 (PDF)
This book is a reprint of the Special Issue Mesothelioma Heterogeneity: Potential Mechanisms that was published in
Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary
Mesothelioma is a rare aggressive cancer that develops from the mesothelium. Recent molecular analyses have defined four different types of mesothelioma based on gene expression and two major molecularly-defined groups based on prognosis. In this volume, potential mechanisms causing this heterogeneity are explored. The different chapters include heterogeneity learned from experimental animal models in NF2/Hippo pathway signaling, stem cell signaling pathways, the tumor microenvironment, and micro RNA secretome. Novel aspects deserving attention such as the implication of long, non-coding RNA in disease heterogeneity are described. The volume also includes the description of tools useful to address some specific questions such as an assessment of the copy number variations of two tumor suppressors frequently mutated in mesothelioma or an investigation of Macrophage Inhibition Factor signaling in mesothelioma.
Format
- Paperback
License
© 2019 by the authors; CC BY-NC-ND license
Keywords
peritoneum; mesothelioma; molecular-array; asbestos; malignant pleural mesothelioma (MPM); tumor microenvironment heterogeneity; molecular pathways; tumor suppressors; immunotherapy; developmental cell pathways; malignant pleural mesothelioma; microRNAs; diagnosis biomarkers; malignant mesothelioma; neurofibromatosis type 2 (NF2); merlin; Hippo signaling pathway; PI3K/AKT/mTOR signaling pathway; malignant pleural mesothelioma (MPM); tumor microenvironment (TME); heterogeneity; immunotherapy; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); tumor-infiltrating lymphocytes (TIL); regulatory T cells (Tregs); mesothelioma heterogeneity; non-coding RNA; long-non-coding RNA; malignant pleural mesothelioma; long non-coding RNAs (lncRNAs); epithelial- mesenchymal transition; mesothelioma; inter-tumor heterogeneity; temporal intra-tumor heterogeneity; spatial intra-tumor heterogeneity; chemoresistance; cancer stem cells; targeted therapy; cancer; pleura; mesothelioma; orthotopic xenotransplantation; athymic mouse; immune cells; malignant mesothelioma; mesothelium; mineral fibres; gene mutations; tumor suppressor genes; signalling pathways; carcinogenesis; mesothelioma; biomarker; FISH; genomic deletion; copy number variation; ddPCR; mesothelioma heterogeneity; NF2/Hippo pathway; BAP1; non-coding RNA; tumor microenvironment; experimental models