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Authors = Manuel Perera-Lecoin

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20 pages, 1176 KB  
Review
Flavivirus Entry Receptors: An Update
by Manuel Perera-Lecoin, Laurent Meertens, Xavier Carnec and Ali Amara
Viruses 2014, 6(1), 69-88; https://doi.org/10.3390/v6010069 - 30 Dec 2013
Cited by 261 | Viewed by 24274
Abstract
Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that concentrate and/or recruit viruses on the cell [...] Read more.
Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that concentrate and/or recruit viruses on the cell surface and primary receptor(s) that bind to virions and direct them to the endocytic pathway. Here, we present the currently available knowledge regarding the flavivirus receptors described so far with specific attention to C-type lectin receptors and the phosphatidylserine receptors, T-cell immunoglobulin and mucin domain (TIM) and TYRO3, AXL and MER (TAM). Their role in flavivirus attachment and entry as well as their implication in the virus biology will be discussed in depth. Full article
(This article belongs to the Special Issue West Nile Virus)
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