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Authors = Ilya V. Pyko

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37 pages, 1381 KB  
Review
Aberrant Signaling Pathways in Glioma
by Mitsutoshi Nakada, Daisuke Kita, Takuya Watanabe, Yutaka Hayashi, Lei Teng, Ilya V. Pyko and Jun-Ichiro Hamada
Cancers 2011, 3(3), 3242-3278; https://doi.org/10.3390/cancers3033242 - 10 Aug 2011
Cited by 190 | Viewed by 27420
Abstract
Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active [...] Read more.
Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies. Full article
(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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