Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures
Abstract
:1. Introduction
2. Methods
2.1. Patient Population
2.2. MR Imaging
2.3. Image Analysis
2.4. Statistics
3. Results
3.1. Patients’ and Tumor Characteristics
3.2. Tumor Size and Location
3.3. Histogram Analyses
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
Abbreviations
ADC | Apparent diffusion coefficient |
BTE | Brain tumor-related epilepsy |
FA | Fractional anisotropy |
FLAIR | Fluid-attenuated inversion recovery |
GB | Glioblastoma |
MPRage | Magnetization prepared rapid gradient echo |
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Age | 64 Years (+/-13.9) |
---|---|
Sex, male | 90/160 |
Preoperative seizure | 60/160 |
Tumor infiltration of | |
- frontal lobe | 87/160 |
- temporal lobe | 93/160 |
- parietal lobe | 57/160 |
- occipital lobe | 37/160 |
- insula | 90/160 |
- hippocampus | 51/160 |
- cerebellum | 4/160 |
- brainstem | 13/160 |
Hemisphere | |
- right | 74/160 |
- left | 64/160 |
- both | 22/160 |
IDH1-wildtype | 108/109 |
MR Sequence | Seizure | No Seizure | adj. p-Value |
---|---|---|---|
FLAIR | 48884.4 mm3 (31830.9–97074.7) | 85391.7 mm3 (54260.2–124244.1) | 0.725 |
CET* | 8434.9 mm3 (3604.9–17662.9) | 14805.7 mm3 (8196.8–26347.5) | 0.029 |
Location | Seizure (n = 60) | No Seizure (n = 100) | Odds Ratio | Perm. p-Value |
---|---|---|---|---|
Left superior frontal gyrus | 17 | 38 | 0.645 | 0.857 |
Right superior frontal gyrus | 19 | 43 | 0.614 | 0.140 |
Left middle frontal gyrus | 16 | 29 | 0.890 | 1 |
Right middle frontal gyrus | 15 | 41 | 0.480 | 0.172 |
Left inferior frontal gyrus | 16 | 27 | 0.983 | 1 |
Right inferior frontal gyrus | 13 | 37 | 0.471 | 0.248 |
Left precentral gyrus | 19 | 30 | 1.081 | 1 |
Right precentral gyrus | 18 | 50 | 0.429 | 0.091 |
Left middle orbitofrontal gyrus | 9 | 20 | 0.706 | 1 |
Right middle orbitofrontal gyrus | 4 | 25 | 0.214 | 0.064 |
Left lateral orbitofrontal gyrus | 9 | 19 | 0.752 | 1 |
Right lateral orbitofrontal gyrus | 6 | 27 | 0.300 | 0.214 |
Left gyrus rectus | 2 | 12 | 0.253 | 1 |
Right gyrus rectus | 4 | 11 | 0.578 | 0.783 |
Left postcentral gyrus | 15 | 21 | 1.254 | 0.999 |
Right postcentral gyrus | 16 | 46 | 0.427 | 0.200 |
Left superior parietal gyrus | 9 | 14 | 1.084 | 1 |
Right superior parietal gyrus | 15 | 29 | 0.816 | 1 |
Left supramarginal gyrus | 9 | 12 | 1.294 | 1 |
Right supramarginal gyrus | 10 | 30 | 0.467 | 0.072 |
Left angular gyrus | 14 | 16 | 1.598 | 0.991 |
Right angular gyrus | 12 | 26 | 0.712 | 0.935 |
Left precuneus | 9 | 13 | 1.181 | 1 |
Right precuneus | 11 | 26 | 0.639 | 1 |
Left superior occipital gyrus | 6 | 7 | 1.476 | 1 |
Right superior occipital gyrus | 8 | 21 | 0.579 | 0.873 |
Left middle occipital gyrus | 9 | 9 | 1.784 | 0.449 |
Right middle occipital gyrus | 10 | 21 | 0.752 | 1 |
Left inferior occipital gyrus | 7 | 10 | 1.189 | 1 |
Right inferior occipital gyrus | 8 | 10 | 1.385 | 1 |
Left cuneus | 8 | 8 | 1.769 | 0.995 |
Right cuneus | 7 | 13 | 0.884 | 1 |
Left superior temporal gyrus | 24 | 31 | 1.484 | 0.943 |
Right superior temporal gyrus | 18 | 46 | 0.503 | 0.266 |
Left middle temporal gyrus | 21 | 27 | 1.456 | 0.999 |
Right middle temporal gyrus | 14 | 39 | 0.476 | 0.125 |
Left inferior temporal gyrus | 20 | 26 | 1.423 | 0.998 |
Right inferior temporal gyrus | 15 | 26 | 0.949 | 1 |
Left parahippocampal gyrus | 19 | 27 | 1.253 | 1 |
Right parahippocampal gyrus | 14 | 31 | 0.677 | 0968 |
Left lingual gyrus | 11 | 19 | 0.957 | 1 |
Right lingual gyrus | 12 | 25 | 0.750 | 0.995 |
Left fusiform gyrus | 17 | 24 | 1.252 | 1 |
Right fusiform gyrus | 13 | 30 | 0.645 | 0.999 |
Left insular cortex | 18 | 32 | 0.911 | 1 |
Right insular cortex | 18 | 46 | 0.503 | 0.266 |
Left cingulate gyrus | 18 | 42 | 0.592 | 0.877 |
Right cingulate gyrus | 19 | 49 | 0.482 | 0.048 |
Left caudate | 19 | 35 | 0.861 | 1 |
Right caudate | 14 | 45 | 0.372 | 0.009 |
Left putamen | 20 | 36 | 0.889 | 1 |
Right putamen | 19 | 49 | 0.482 | 0.187 |
Left hippocampus | 18 | 27 | 1.159 | 1 |
Right hippocampus | 15 | 36 | 0.593 | 0.476 |
cerebellum | 9 | 15 | 1.000 | 1 |
brainstem | 12 | 29 | 0.612 | 1 |
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Bette, S.; Barz, M.; Nham, H.L.; Huber, T.; Berndt, M.; Sales, A.; Schmidt-Graf, F.; Meyer, H.S.; Ryang, Y.-M.; Meyer, B.; et al. Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures. Cancers 2020, 12, 994. https://doi.org/10.3390/cancers12040994
Bette S, Barz M, Nham HL, Huber T, Berndt M, Sales A, Schmidt-Graf F, Meyer HS, Ryang Y-M, Meyer B, et al. Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures. Cancers. 2020; 12(4):994. https://doi.org/10.3390/cancers12040994
Chicago/Turabian StyleBette, Stefanie, Melanie Barz, Huong Ly Nham, Thomas Huber, Maria Berndt, Arthur Sales, Friederike Schmidt-Graf, Hanno S. Meyer, Yu-Mi Ryang, Bernhard Meyer, and et al. 2020. "Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures" Cancers 12, no. 4: 994. https://doi.org/10.3390/cancers12040994