Sci

Pharmacy is not only a science; it is also a profession, a trade and an art. As such, it frequently encounters society, where it leaves its impact in a way which is probably unique among the natural and life sciences. In turn, individuals and society have become increasingly dynamic and also often critical of modern pharmacy and its products. This poses a multitude of intra- and extra-scientific questions which cannot be studied with the traditional tools of pharmacy. Addressing them requires additional expertise from a wide range of disciplines, including social sciences, psychology, ethics and other branches of philosophy. Pharmasophy aims to bring this kind of wisdom to pharmacy by taking a holistic view of pharmacy and pharmaceuticals, from the process of research and development to regulation, distribution, application and compliance. In doing so, it aims to master some of the challenges facing pharmacy in the 21st century Full article

Although linseed oil (LO) has been used in wood protection for centuries, research continues to develop new and more effective formulations and treatment approaches. In the future, growing interest in LO use could be expected due to its cost and environmental friendliness. This review summarizes recent research (from 2000 onwards) on the use of LO in wood protection, published in peer-reviewed scientific journals and included in the online publication databases Scopus or Web of Science. The studies cover surface and impregnation treatments of various wood substrates using different LO formulations, including chemically modified LO and the use of LO as a base for the development of biofinish and as a medium for thermal modification of wood, as well as research into the mechanisms behind the changes in wood properties due to treatment methods and interaction with LO formulations. Although the improvement of wood hydrophobicity and biodurability dominates, other aspects such as weathering and color stability, adhesion, and environmental safety are included in these studies. In general, almost all of the studies show a greater or lesser potency of the proposed approaches to provide benefits in wood protection; however, the level of innovation and practical feasibility varies. Full article

The aim of this study was to evaluate the influence of different ventilation systems in two aging cells. One cell featured transverse airflow starting from the top, while the other had a dual-flow system with vertical air motion from top to bottom and vice versa. In addition to monitoring weight loss during aging, chemical and physical analyses were conducted on various salamis to assess the influence of ventilation both between the two aging cells and among different positions of the salamis within the same cell. It was found that the dual-evaporator (DEV) cell behaved better than transverse flow (TFL) cell. Full article

Rural roads, often characterized by winding paths and nearby settlements, feature frequent curvature changes, junctions, and closely spaced private accesses that lead to significant speed variations. These variations are typically represented by average speed or v₈₅ profiles. This paper examines complete speed distributions along rural two-lane roads using Floating Car Data (FCD). The Wasserstein distance, a non-parametric similarity measure, is employed to compare speed distributions recorded by a radar Control Unit (CU) and a selected FCD sample. Initially, FCD speeds were validated against CU speeds. Subsequently, differences in speed distributions between the CU location and specific sections identified by sharp curves, intersections, or accesses have been assessed. The Wasserstein Distance is proposed as the most effective synthetic indicator of speed distribution variability along roadways, attributed to its metric properties. This measure offers a more concise and immediate assessment compared to an extensive array of statistical metrics, such as mean, median, mode, variance, percentiles, v₈₅, interquartile range, kurtosis, and symmetry, as well as qualitative assessments derived from box plot trends. Full article

Cloud manufacturing allows multiple manufacturers to contribute their manufacturing facilities and assets for monitoring, operating, and controlling common processes of manufacturing and services controlled through cloud computing. The modern framework is driven by the seamless integration of technologies evolved under Industry 4.0. The entire digitalized manufacturing systems operate through the Internet, and hence, cybersecurity threats have become a problem area for manufacturing companies. The impacts can be very serious because cyber-attacks can penetrate operations carried out in the physical infrastructure, causing explosions, crashes, collisions, and other incidents. This research is a thematic literature review of the deterrence to such attacks by protecting IoT devices by employing provenance blockchain and artificial intelligence. The literature review was conducted on four themes: cloud manufacturing design, cybersecurity risks to the IoT, provenance blockchains for IoT security, and artificial intelligence for IoT security. These four themes of the literature review were critically analyzed to visualize a framework in which provenance blockchain and artificial intelligence can be integrated to offer a more effective solution for protecting IoT devices used in cloud manufacturing from cybersecurity threats. The findings of this study can provide an informative framework. Full article

Rechargeable zinc-ion batteries (ZIBs) have grown in popularity due to their low cost and the abundance of resources. However, there has been little research into the development of gel polymer electrolytes (GPEs) for high voltage and capacity ZIBs. The use of agricultural waste as a polymer electrolyte (PE) is gradually increasing in order to support a circular economy. This study focuses on the utilization of cellulose derived from coffee silverskin (CS); coffee silverskin is a by-product generated during coffee roasting. We employ a reasonable approach to create the coffee silverskin cellulose (CSC)/polyacrylamide (PAM) GPE, with the goal of achieving good properties and improved battery performance. An investigation was conducted to determine the effect of CSC content in GPEs on ZIB characteristics. The cellulose derived from CS had a crystallinity index (CrI) of 64.60%. The optimal amount of cellulose added to the acrylamide monomer (AM) for the GPE of ZIB was found to be 2.5 mg (CSC/AM/salt weight ratio of 0.01/6/23). This amount resulted in the highest electrochemical stability and a cycling time of approximately 226 h. Furthermore, the PAM/Cellulose 2.5-based GPE exhibited increased Young’s modulus and tensile strength compared to the pure PAM. The electrochemical impedance spectroscopy (EIS) test revealed a diffusion resistance of 27.47 Ω and an ionic conductivity of 9.10 mS/cm at a temperature of 25 °C. Additionally, the use of cellulose in GPEs does not affect the electrochemical window. When the pure PAM-based GPE was compared to the CSC/PAM-based GPE, the biocomposites demonstrated electrochemical stability for a cycle life of over 200 cycles in the ZIB application. Full article

Permeability measurement of engineering textiles is a key step in preparing composite manufacturing processes. A radial flow experimental setup was used in this work to measure the unsaturated and saturated in-plane permeabilities of five different types of E-glass textiles and their ratios. In parallel, delayed tow saturation during the oil injection stage was visually observed to identify fabrics that exhibited a significant dual-scale effect. A numerical approach to determine the saturated permeability of a given fabric geometry at the mesoscale was tested and validated against analytical models found in the literature. It was then applied to a realistic geometry acquired from an E-glass plain weave textile using an X-ray microtomography scanner (μCT). Two numerical methods were adopted: the single-scale method, where the tows are considered impermeable, and the dual-scale method, where the permeability of the tows is taken into account. The numerical results from both methods were then compared with the experimental values and showed good agreement, especially with the second method. Full article

The well-known Gaussian plume model has proven to be very useful in simulating the atmospheric dispersion of air pollutants (both gaseous and particulates). Nevertheless, the nature of the model presents problems in the actual computation of concentrations when the plume is confined between two parallel boundaries due to the occurrence of multiple reflections. The ground and temperature inversion lid (especially, when the inversion layer is at low levels in the atmosphere) with a chimney stack releasing the effluent below the latter, is one contextual example of horizontal parallel reflecting boundaries. A second example is buildings confining a roadway on either side, with motor vehicles emitting pollution within the street canyon (or urban notch). In such cases, multiple reflections should be accounted for, otherwise the model underpredicts the resulting concentration. This paper presents a mathematical rewriting of the Gaussian plume model equation corrected for multiple reflections when the pollution source is confined between parallel boundaries. The obtained result is most appropriate when the parallel boundaries are rigid, and near-complete reflection is achieved, e.g., street canyon environment (second quoted example). It is worth noting that the relevant mathematical derivations and definitions are all included in the paper to facilitate reading and to ensure comprehensiveness in the presentation. Additionally, the outcome of some preliminary numerical testing is presented. The latter indicates that the new formulation is mathematically stable and yields interesting results. Further numerical investigation and experimental evaluation are merited. Full article

Radiotherapy plays a key role in the treatment of the early and advanced stages of head and neck cancer. To date, there is still no consensus on the effects of radiotherapy on the mechanical properties of fluoride-releasing restorative materials which can be used in patients undergoing radiotherapy with increased incidence of caries. The fluoride-releasing materials Equia Forte HT and Cention N were compared to the resin-based materials Tetric EvoCeram and Tetric Power Fill. Standard irradiation was performed with a linear accelerator. Vickers microhardness, mass, surface roughness and color were measured before and after irradiation. Cention N and Tetric PowerFill showed stability in the mass, while the surface roughness did not change in any of the examined groups. Resistance to microhardness change was shown by Cention N, Tetric PowerFill and Tetric EvoCeram, and the color change was significant in all groups (p < 0.05). It should be remembered that patients receiving head and neck radiation therapy may experience adverse effects from the treatment, including changes in the mechanical properties of the restorative materials. The obtained results suggest that Cention N can be used as a material in patients undergoing head and neck radiotherapy due to the mechanical stability and depo effect of fluoride release. Full article

Hormone replacement therapy (HRT) is a treatment for acute climacteric syndrome, with the best effectivity. It also prevents bone loss and fractures. Ischemic heart disease prevention and cognitive function improvement have been observed with HRT, only when started early (critical window hypothesis). There is a large scale of complementary and alternative medicines for women in preference to non-hormonal treatment. Unfortunately, they do not always accompany reliable documentation of efficacy and safety from well-performed studies. Full article

This study investigates the potential health risks associated with consuming mussels (Mytilus galloprovincialis Lamarck, 1819) from the Romanian Black Sea coast between 2001 and 2023. The research focuses on heavy metal (copper, cadmium, lead, nickel, and chromium) bioaccumulation in mussels and the associated human health hazards. While most metals fell within safe limits, lead and cadmium exceeded the maximum admissible concentrations set by the European Commission in a small percentage of samples (10% for cadmium, 14% for lead). To assess human health risks, we calculated dietary intake estimates and hazard quotients. These calculations suggested that current metal concentrations in the mussels are unlikely to cause adverse health effects at typical consumption levels. Although current metal concentrations seem safe based on estimated intake and hazard quotients, we emphasize the need for continuous monitoring of pollutants in seafood to ensure consumer safety. Future research should consider the cumulative effects of various contaminants and how individual factors like age and health conditions might influence risk. Public health protection requires continuous monitoring, comprehensive risk assessments, and transparent communication between scientists, policymakers, and the public to establish safe consumption guidelines. Full article

Preliminary monitoring campaigns in three (nonindustrial) indoor environments (a corridor, a coffee room with a kitchenette, and a single-occupancy office, all located in the same public building) were carried out, in which the vertical concentration profiles of airborne particulate matter (inhalable, thoracic, and alveolic fractions, as well as PM₁₀ and PM_2.5) and carbon dioxide were determined using two distinct, purpose-built sequential sampling systems. One of the systems was specifically built for use with gas monitors and is based on the organ-pipe sequential air sampling technique. The second system better suited the sequential air sampling of particulate matter. Both systems were electronically controlled. Six receptor levels at heights of 0.25, 0.95, 1.25, 1.65, 2.15, and 2.75 m above the ground/floor were considered. The outcomes of the campaigns are presented. The larger-size particle fractions exhibited the most vertical variation in concentration. With respect to measurements at a height of 1.25 m above the floor, percentage differences as high as 80% were recorded. Given the appreciable measured variation in concentration over a height of approximately three meters, further investigation is warranted, especially in view of the exposure of humans of different heights, e.g., adults and children, and possibly different circumstances, e.g., standing and sitting. Full article

This study explores the feasibility of producing electrolyzed water (EW) for post-harvest treatment of fruits and vegetables as a new substitute for current chemical products. A prototype generator using tap water and NaCl solution was tested for EW’s sanitization efficiency, energy, and economic costs. In vitro tests on Penicillium e., Aspergillus n., Botrytis c., and Alternaria a. assessed EW pH, chlorine concentration, electro-oxidative potential, pathogen contact time, and energy consumption. Optimal results were achieved with a pH of 4.6, electro-oxidative potential of 188 mV, active chlorine concentration of 3.4 mg/L, and a contact time of 1–2 min. The prototype produced 10.0 L of EW in 1 h, consuming 0.11 kWh of electricity. Real-scale energy consumption was 545 kWh/m³ EW, costing 12.51 euro/m³. The study concludes that optimizing EW production can reduce energy consumption, making it a viable alternative for industrial sanitization of fruits and vegetables. Full article

Italy built its ammasso silo network in the 1930s for two purposes: to stockpile grain and to symbolize fascist power. Much of the network was destroyed in World War II, and over half of the silos still standing are now disused and in disrepair. These structures should be protected and refurbished because they are part of Italy’s historic and agro-industrial heritage and because reusing existing buildings instead of constructing new ones reduces the carbon footprint. To evaluate silo repurposing potential, a method developed for inventorying Spanish silos was adapted and applied to the 30 remaining ammasso silos. The method explores the general features, construction, equipment, and socioeconomic environment of each silo. All extant ammasso silos have machinery for receiving, storing, and dispatching grain, and most have equipment for cleaning, sorting, weighing, and packaging. Vertical-cell silos are challenging to convert, unlike horizontally-oriented silos and other open-plan agro-industrial buildings. Even so, some have already been made over into shops, leisure areas, museums, and even homes. Examples of silo reuse in other countries, such as Spain and Portugal, can offer further useful insights. However, socio-economic indicators suggest that silo repurposing projects are viable only in large population centres. Full article

An automated device is designed to measure the density of a liquid material using hydrostatic pressure method. A low cost pressure sensor is calibrated and used to get highly accurate readings. The calibration is done by measuring the pressure values vs. the generated voltage signal. The calibration has been challenging due to the low accuracy of the sensor but proved to be highly effective in applications. The interface is developed using a microcontroller, motor drives, analog to digital converters and sensors. The device is designed to get several readings automatically by changing the positions of the device/liquid column heights to increase the accuracy. Also the device can be programmed to measure the real time density of a liquid continuously. The readings were analyzed and averaged by a software developed in python language. The instruments accuracy was tested against 3 liquid types, water, coconut oil, kerosene oil, and showed a low error (0.007%, 0.001%, and 0.002% respectively) compared to the readings of a standard Pycnometer. The low error percentages confirm the accuracy of the device and the effectiveness of the sensor calibrations. Full article

Throughout history, the implementation of structural health monitoring systems has played a crucial role in evaluating the responses of dams to environmental and human-induced threats. By continuously monitoring structural integrity and analyzing dynamic characteristics, these systems offer a robust alternative to traditional visual inspection methods, ensuring the long-term safety of dams. This paper delves into the intricate process of operational modal analysis applied to dams, encompassing data collection, preprocessing, and the utilization of diverse modal identification techniques across both time and frequency domains. Moreover, it explores innovative approaches aimed at overcoming challenges encountered in previous methodologies. Also, the evolution of automated modal identification techniques and their application in dams are investigated. It explores the advancements in this field and their implications for enhancing the efficiency and accuracy of modal analysis processes. Furthermore, this paper evaluates the effectiveness of damage detection methods in dams based on operational modal identification. Full article

Modeling and simulation have been used to study tsunamis for several decades. We created a review to identify the software and methods used in the last decade of tsunami research. The systematic review was based on the PRISMA methodology. We analyzed 105 articles and identified 27 unique software and 45 unique methods. The reviewed articles can be divided into the following basic categories: exploring historical tsunamis based on tsunami deposits, modeling tsunamis in 3D space, identifying tsunami impacts, exploring relevant variables for tsunamis, creating tsunami impact maps, and comparing simulation results with real data. Based on the outcomes of this review, this study suggests and exemplifies the possibilities of system dynamics as a unifying methodology that can integrate modeling and simulation of most identified phenomena. Hence, it contributes to the development of tsunami modeling as a scientific discipline that can offer new ideas and highlight limitations or a building block for further research in the field of natural disasters. Full article

Currently, the most common method of silane synthesis for electronics and photovoltaics is trichlorosilane dismutation. Therefore, an experimental study of the kinetics of the dismutation reaction of chlorosilanes is of scientific and practical interest. A catalyst has been proposed that allows the dismutation reaction to be carried out in a wide range of temperatures and pressures. Both kinetic and thermodynamic data on the dependence of the rate of the dismutation reactions of trichlorosilane, dichlorosilane, and monochlorosilane on pressure were experimentally obtained. In addition, the dependence of saturated vapor pressure on temperature for monochlorosilane and dichlorosilane were also experimentally determined. Using the example of TCS, it was experimentally established that increasing the pressure to six atmospheres makes it possible to increase the specific productivity of the reactor by at least an order of magnitude due to the acceleration of the chemical reaction and the increase in the molar concentration of chlorosilanes in the vapor mixture. Consequently, it becomes possible to multiply the reactor’s load on the substance and, accordingly, the performance of the chlorosilane dismutation apparatus in general. Full article

Technology acquisitions are one of the most common growth strategies for firms. Firms that have made multiple acquisitions in the past are more likely to make new ones. With previous M&A experience, firms are more likely to make acquisitions. The acquisition rate is the total number of acquisitions a firm has made at a given time. In technology acquisition, the acquisition rate affects innovative firm performance. The more frequent acquisitions a firm makes, the less innovative performance will occur. A high acquisition rate negatively affects post-acquisition performance by dominating the attention of decision-makers and overloading the firm. During the process, there needs to be structural integration between the acquirer and the target firm. This study empirically analyzes 380 cases of technology acquisitions of U.S. publicly traded companies from 1990 to 2005. The results show that a high acquisition rate is negatively related to the post-acquisition innovation performance of the acquirer. Although structural integration has no impact on the negative relationship between post-acquisition performance and acquisition rate, considering the acquisition rate when pursuing M&A allows acquiring firms to avoid detrimental consequences. Full article