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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Personalized Modern Oncological Strategies for Breast Cancer Treatment
edited by Vlad Alexandru Gata, Maximilian Muntean and
submission deadline 22 Jan 2026 | Viewed by 169
Keywords: breast cancer; targeted and immune therapies; predictive biomarkers; surgical de-escalation; MRI of the breast; breast reconstruction
(This special issue belongs to the Section General Surgery)
Clinical Advances and New Challenges in Laparoscopic Surgery
edited by Ionut Bogdan Diaconescu and Matei Bratu
submission deadline 23 Jan 2026 | Viewed by 197 | Submission Open
Keywords: laparoscopic surgery; trauma surgery; surgical oncology; abdominal surgery; colorectal surgery; general surgery; minimally invasive surgery; gastrointestinal surgery; hernia surgery; surgery; advance laparoscopic surgery; cancer surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Glaucoma: Current Status and Prospects
edited by Rubén Sánchez-Jean, and Federico Sáenz-Francés San Baldomero
submission deadline 24 Jan 2026 | 2 articles | Viewed by 4782 | Submission Open
Keywords: glaucoma surgery; new techniques; minimally invasive glaucoma surgery; intraocular pressure; optometry; IOLs designs
(This special issue belongs to the Section Ophthalmology)
Pediatric Pulmonology: Recent Developments and Emerging Trends
edited by Athina L. Papadopoulou
submission deadline 25 Jan 2026 | 5 articles | Viewed by 21320 | Submission Open
Keywords: definition of breath sounds; lung– gut axis pathophysiology; disease endotypes and phenotypes; asthma management in children; bronchiolitis spectrum; pediatric bronchopulmonary dysplasia; pulmonary function testing in pediatric patients; pediatric sleep-disordered breathing; neonatal respiratory distress syndrome; childhood interstitial lung diseases; pulmonary hypertension in children; biomarkers in pediatric lung diseases; allergy and the lungs; diagnostic and therapeutic challenges in bronchoscopy; gene therapy in cystic fibrosis
(This special issue belongs to the Section Clinical Pediatrics)
Personalized Medicine for the Management of Non-Communicable Disease (NCDs)
edited by , Giulio Geraci and
submission deadline 25 Jan 2026 | 10 articles | Viewed by 16532 | Submission Open
Keywords: personalized medicine; precision medicine; non-communicable disease; cardiovascular disease; cancer; diabetes; chronic obstructive pulmonary disease; cognitive impairment; atherosclerosis; lipids; inflammation; immunity; therapy
(This special issue belongs to the Section Epidemiology & Public Health)
Male Fertility in the Modern Age: Challenges and Opportunities
edited by
submission deadline 25 Jan 2026 | 2 articles | Viewed by 14232 | Submission Open
Keywords: male infertility; semen parameters; sperm selection; IVF/ICSI
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond
edited by
submission deadline 25 Jan 2026 | 5 articles | Viewed by 13897 | Submission Open
Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors
(This special issue belongs to the Section Cardiovascular Medicine)
Keratoconus: Current Status and Prospects
edited by and Isabel Lema
submission deadline 25 Jan 2026 | 3 articles | Viewed by 11948 | Submission Open
Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances
(This special issue belongs to the Section Ophthalmology)
Prevention, Diagnosis and Treatment of Oral Mucosal Diseases
edited by
submission deadline 25 Jan 2026 | 4 articles | Viewed by 11498 | Submission Open
Keywords: oral mucosal diseases; oral mucositis; oral precancerous lesions; oral cancer; oral potentially malignant disorders; OPMDs; oral leukoplakia
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Treatment for Venous Thromboembolism
edited by and Georgia Kaiafa
submission deadline 25 Jan 2026 | 3 articles | Viewed by 5659 | Submission Open
Keywords: venous thromboembolism; anticoagulation; cancer-associated thrombosis; thrombosis in MPNs; thrombosis in multiple myeloma; antiphospholipidic syndrome; thrombosis in PNH; thrombosis in hemoglobinopathies; thrombophilia; pregnancy and thrombophilia; reversal of anticoagulants; thromboprophylaxis
(This special issue belongs to the Section Hematology)
Foot and Ankle Surgery: Current Advances and Prospects
edited by
submission deadline 25 Jan 2026 | 4 articles | Viewed by 5627 | Submission Open
Keywords: foot and ankle surgery; foot pathologies; ankle disease and trauma; diabetic foot; epidemiology; clinical anatomy; foot orthoses; weight-bearing CT
(This special issue belongs to the Section Orthopedics)
Autism Spectrum Disorder: Diagnosis, Treatment, and Management
edited by
submission deadline 25 Jan 2026 | 3 articles | Viewed by 4982 | Submission Open
Keywords: adult autism (including autism spectrum disorders); neurodevelopmental disorders; clinical diagnostics; digital diagnostics; artificial intelligence; multimodal treatments
(This special issue belongs to the Section Mental Health)
Clinical Diagnostic and Therapeutic Approaches in Cardiac Amyloidosis
edited by Grigorios Giamouzis
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3766 | Submission Open
Keywords: cardiac amyloidosis; transthyretin amyloidosis; hypertrophic cardiomyopathy; cardiac imaging; heart failure
(This special issue belongs to the Section Cardiology)
Clinical Updates in Cardiac Electrophysiology: 2nd Edition
edited by Kenneth C. Bilchick
submission deadline 25 Jan 2026 | 1 articles | Viewed by 3576 | Submission Open
Keywords: arrhythmias; atrial fibrillation; cardiac electrophysiology; heart rhythm disorders; ablation; ventricular tachycardia; remote monitoring; digital health; artificial intelligence; cardiac magnetic resonance
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Diseases: Clinical Advances and Emerging Therapies submission deadline 25 Jan 2026 | 3 articles | Viewed by 3281 | Submission Open
Keywords: inflammatory bowel disease (IBD); ulcerative colitis; Crohn’ s disease; gut inflammation; bowel perforation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition
edited by , Peter Niclas Broer and Denis C. Ehrl
submission deadline 25 Jan 2026 | 2 articles | Viewed by 2233 | Submission Open
Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Shoulder and Elbow Surgery: Clinical Updates and Perspectives
edited by Taku Hatta, Akihiko Hasegawa and Takuma Yuri
submission deadline 25 Jan 2026 | 2 articles | Viewed by 1316 | Submission Open
Keywords: rotator cuff injuries; shoulder arthroplasty; elbow surgery; shoulder surgery; shoulder and elbow disease; arthroscopic surgery; orthopedic surgery
(This special issue belongs to the Section Orthopedics)
Kidney Transplantation: Challenges, Advances and Lessons Learnt submission deadline 25 Jan 2026 | 3 articles | Viewed by 1153 | Submission Open
Keywords: kidney transplantation; nephrology; transplant medicine; patient selection criteria; immunosuppressive treatment; long-term outcomes; graft survival; complication; multi-organ transplant consideration; innovation
(This special issue belongs to the Section Nephrology & Urology)
Ocular Surface Disease: Epidemiology, Diagnosis and Management submission deadline 25 Jan 2026 | Viewed by 1018 | Submission Open
Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Clinical Updates in the Use of Artificial Intelligence for Radiology
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 588 | Submission Open
Keywords: deep learning; denoising; calculator; nn-UNet; automation; outcomes; quality control; DICE; Halsdorrf; Jaccard
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Machine Learning and Artificial Intelligence in Neurosurgery
edited by Jan Oliver Neumann and
submission deadline 25 Jan 2026 | Viewed by 573 | Submission Open
Keywords: artificial intelligence; neurosurgery; neuro-oncology; spinal neurosurgery; neuro-ICU; stereotactic neurosurgery; pre-operative planning
(This special issue belongs to the Section Clinical Neurology)
Recent Clinical Advances in Reconstructive Urology and Prosthetic Surgery
edited by Elisa Berdondini and
submission deadline 25 Jan 2026 | Viewed by 224 | Submission Open
Keywords: reconstructive urology; penile prosthesis; artificial urinary sphincter; urethral stricture; reconstructive surgery; minimally invasive procedures
(This special issue belongs to the Section Nephrology & Urology)
Otologic Disorders and Hearing Impairment: From Diagnosis to Rehabilitation
edited by Andrea Albera and Andrea Canale
submission deadline 25 Jan 2026 | Viewed by 153 | Submission Open
Keywords: otology; hearing loss; cochlear implants; middle ear surgery; otitis media; otosclerosis; auditory rehabilitation; ves-tibular disorders; hearing aid; bone-conduction implants
(This special issue belongs to the Section Otolaryngology)
Novel Developments on Diagnosis and Treatment of Atrial Fibrillation
edited by and Mihaela-Viviana Ivan
submission deadline 26 Jan 2026 | 5 articles | Viewed by 7173 | Submission Open
Keywords: atrial fibrillation; supraventricular arrhythmia; cardiovascular risk; oxidative stress; inflammation
(This special issue belongs to the Section Cardiovascular Medicine)
New Insights into Peritoneal Dialysis and Hemodialysis: 2nd Edition submission deadline 26 Jan 2026 | 2 articles | Viewed by 3192 | Submission Open
Keywords: hemodialysis; peritoneal dialysis; end-stage renal disease; kidney replacement therapy (KRT); pathophysiology; di-alysis membranes; dialysis preparation; dialysis modality; cardiovascular events; vascular access; PD-related perito-nitis; unfavorable adverse effects; complications; challenges; inflammation
(This special issue belongs to the Section Nephrology & Urology)
Osteoporotic Fractures of the Pelvis, Hip and Femur: Current Challenges and New Perspectives (2nd Edition)
edited by Andreas Hoch
submission deadline 26 Jan 2026 | Viewed by 181 | Submission Open
Keywords: osteoporosis; fracture management; pelvic fractures; periprosthetic fractures; proximal femoral fractures; non-operative therapies
(This special issue belongs to the Section Orthopedics)
Challenges in Diagnosis and Treatment of Infertility—2nd Edition
edited by Konstantinos A. Zikopoulos
submission deadline 27 Jan 2026 | 2 articles | Viewed by 7184 | Submission Open
Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Diagnosis and Treatment for Bone Tumor
edited by Antonio Ziranu and Luigi Cianni
submission deadline 27 Jan 2026 | 5 articles | Viewed by 5324 | Submission Open
Keywords: bone tumor; oncology; osteosarcoma; chondrosarcoma; megaprosthesis; bone resection; chemotherapy; radiotherapy; sarcoma; custom-made
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Scleral Lenses: New Insights in Lens Fitting and Customization
edited by and
submission deadline 27 Jan 2026 | Viewed by 608 | Submission Open
Keywords: scleral lenses; scleral lens customization; higher-order aberrations; scleral lens optics; corneoscleral profilometry; keratoconus; ocular surface diseases; dry eye; wavefront-guided correction
(This special issue belongs to the Section Ophthalmology)
Heart Valve Surgery: Recent Trends and Future Perspective
edited by Per Nils J.F. Wierup, Johan Sjögren and Nina Hakacova
submission deadline 27 Jan 2026 | Viewed by 171 | Submission Open
Keywords: heart valve; diagnostics; surgery; echocardiography; computer simulation; prediction models
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Disease: Pathogenesis and Management Strategies
edited by
submission deadline 28 Jan 2026 | 2 articles | Viewed by 2072 | Submission Open
Keywords: inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; biomarkers; risk factors; pharmacology; advanced therapy; endoscopic evaluation and procedures; extraintestinal manifestations; IBD-associated neoplasm
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Evidence and Future Directions in Clostridioides difficile Infection Epidemiology, Diagnosis and Treatment submission deadline 28 Jan 2026 | Viewed by 199 | Submission Open
Keywords: Clostridioides difficile infection; infection control; contact isolation; community-acquired CDI; CDI recurrence; recurrence prevention; rCDI; host and microbiota interaction; antimicrobial treat-ment; microbiota transplant; underdiagnosis
(This special issue belongs to the Section Infectious Diseases)
Acute Myocardial Infarction: Clinical Advances in Prognostic Stratification, Diagnosis, and Treatment submission deadline 29 Jan 2026 | 6 articles | Viewed by 9708 | Submission Open
Keywords: acute myocardial infarction (AMI); atherosclerosis; ST segment elevation myocardial infarction (STEMI); non-ST elevation myocardial infarction (NSTEMI); acute coronary syndrome (ACS); prognosis; coronary CT angiography (CCTA); cardiac magnetic resonance (CMR); reperfusion therapy; antiplatelet therapy
(This special issue belongs to the Section Cardiology)
Cerebral Palsy: Clinical Rehabilitation and Treatment
edited by Joav Merrick and
submission deadline 30 Jan 2026 | 7 articles | Viewed by 20200 | Submission Open
Keywords: cerebral palsy; physiotherapy; occupational therapy; orthopedic management; medical management; rehabilitation approaches
(This special issue belongs to the Section Clinical Neurology)
New Advances in Cardiorenal Syndrome: 2nd Edition submission deadline 30 Jan 2026 | 5 articles | Viewed by 19568 | Submission Open
Keywords: cardiorenal syndrome; outcome; hyperkalemia; acute kidney injury; chronic kidney disease; chronic heart failure
(This special issue belongs to the Section Cardiology)
Advances and Perspectives in Cancer Diagnostics and Treatment
edited by Alexandru E. Eniu, and
submission deadline 30 Jan 2026 | 8 articles | Viewed by 8554 | Submission Open
Keywords: solid tumors; new advances; diagnostics and treatment; clinical– pathological; genetic factors; AI; RWD; radiotherapy; biomarkers; prevention in cancer care; target therapy; immunotherapy
(This special issue belongs to the Section Oncology)
Clinical Updates in Bleeding and Thrombotic Disorders
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 4721 | Submission Open
Keywords: autoimmune-acquired coagulation deficiency; acquired hemophilia A; disseminated intravascular coagulation; thrombotic microangiopathy; venous thromboembolism; acute coronary syndrome; clot waveform analysis; thrombin generation test; thromboelastogram
(This special issue belongs to the Section Hematology)
The Current Status and Future Directions of Pancreatoduodenectomy and Pancreatectomy
edited by , and Somaiah Aroori
submission deadline 30 Jan 2026 | 2 articles | Viewed by 3905 | Submission Open
Keywords: pancreatic resection types; techniques and modifications; anastomotic techniques; open resection; minimally invasive surgery; laparoscopic resection; robotic resection; hybrid resection techniques; pancreatic resection post neoadjuvant treatment; lymphadenectomy; vascular resections; organ-sparing procedures; radicality; indications; complications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Advances in General and Regional Anesthesia
edited by Eleni Laou, Eleana Garini and Giolanda Varvarousi
submission deadline 30 Jan 2026 | 2 articles | Viewed by 3548 | Submission Open
Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety
(This special issue belongs to the Section Anesthesiology)
Advances in Minimally Invasive Surgery: Transformative Technologies, Techniques and Trends
edited by Michail Pitiakoudis
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2418 | Submission Open
Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical innovation; hernia repair; colorectal surgery; gastrointestinal surgery; hepatopancreatobiliary surgery; surgical simulation; virtual reality; augmented reality; artificial intelligence; surgical training; patient outcomes; surgical oncology
(This special issue belongs to the Section General Surgery)
Mind–Body Connection: The Impact of Mental Health on Physical Well-Being
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2355 | Submission Open
Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare
(This special issue belongs to the Section Mental Health)
Insights on Cancer Diagnosis, Treatment and Side Effects Management submission deadline 30 Jan 2026 | 1 articles | Viewed by 1625 | Submission Open
Keywords: cancer diagnosis; cancer treatment; side effects management; oncology; personalized medicine; supportive care
(This special issue belongs to the Section Oncology)
Clinical Outcomes in Bipolar and Depressive Disorders
edited by and Francesco Monaco
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1218 | Submission Open
Keywords: mood disorders; clinical outcomes; treatment response; psychopathology; pathophysiology
(This special issue belongs to the Section Mental Health)
Atrial Fibrillation and Heart Failure: Diagnostic and Therapeutic Challenges and Breakthroughs submission deadline 30 Jan 2026 | Viewed by 281 | Submission Open
Keywords: atrial fibrillation; heart failure; cardiac electrophysiology; ventricular remodelling; rhythm control; catheter abla-tion; neurohormonal activation; biomarkers; ischemia; integrated cardiovascular care
(This special issue belongs to the Section Cardiology)
Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes
edited by , and Federica Giordano
submission deadline 30 Jan 2026 | Viewed by 231 | Submission Open
Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile
(This special issue belongs to the Section Oncology)
Causes and Advanced Treatments of Macular Edema submission deadline 31 Jan 2026 | 4 articles | Viewed by 9252 | Submission Open
Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT
(This special issue belongs to the Section Ophthalmology)
The Role of Biomarkers in Cardiovascular Diseases
edited by Giorgia Panichella
submission deadline 31 Jan 2026 | 5 articles | Viewed by 9169 | Submission Open
Keywords: biomarkers; cardiovascular diseases; heart failure; ischemic heart disease; cardiomyopathy; risk stratification; diagnosis; prognosis; inflammation
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Management, Diagnosis and Treatment of Thoracic Diseases: 2nd Edition submission deadline 31 Jan 2026 | 4 articles | Viewed by 7699 | Submission Open
Keywords: lung; thorax; pneumonia; chest; imaging; ultrasound
(This special issue belongs to the Section Respiratory Medicine)
Acute Coronary Syndromes: Clinical Advances in Diagnosis and Treatment
edited by Pierre Sabouret, and
submission deadline 31 Jan 2026 | 3 articles | Viewed by 5143 | Submission Open
Keywords: acute coronary syndromes; myocardial infarction; cardiac biomarkers; antiplatelet therapy; revascularization; precision medicine; risk stratification
(This special issue belongs to the Section Cardiology)
Thoracic Surgery: Updates and New Trends
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 3428 | Submission Open
Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
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