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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management of Type 1 Diabetes
edited by Carmen Quirós
submission deadline 25 Nov 2025 | 7 articles | Viewed by 31143
Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens
(This special issue belongs to the Section Endocrinology & Metabolism)
Neurovascular Diseases: Clinical Advances and Challenges
edited by , Silky Chotai, Alessandro Di Rienzo and Joham Choque-Velasquez
submission deadline 25 Nov 2025 | 11 articles | Viewed by 20917
Keywords: neurovascular diseases; ischemic stroke; hemorrhagic stroke; aneurysms; vascular malformations; diagnostic imaging; minimally invasive approaches; surgical techniques; endovascular interventions; treatment algorithms
(This special issue belongs to the Section Clinical Neurology)
Perinatal Mental Health Management submission deadline 25 Nov 2025 | 6 articles | Viewed by 20566
Keywords: perinatal mental health; child mental health; problem behavior; cognitive development therapy; hyperactivity
(This special issue belongs to the Section Mental Health)
Ventilation in Critical Care Medicine: 2nd Edition
edited by Gianluca Zani
submission deadline 25 Nov 2025 | 2 articles | Viewed by 14008
Keywords: invasive ventilation; non-invasive ventilation; acute respiratory failure; best PEEP; respiratory weaning; respiratory mechanics; ventilation and perfusion; personalized ventilation
(This special issue belongs to the Section Intensive Care)
Glomerulonephritis: Current Diagnosis, Treatment and Future Options
edited by Ana I. Ávila and
submission deadline 25 Nov 2025 | 3 articles | Viewed by 13038
Keywords: glomerulonephritis; diagnosis; management; drug therapies; treatment
(This special issue belongs to the Section Nephrology & Urology)
Challenges in Diagnosis and Treatment of Gynecological Malignancies in Young Adults
edited by , Dimitrios Haidopoulos and
submission deadline 25 Nov 2025 | 4 articles | Viewed by 11484
Keywords: gynecological cancers; young adults; young women; fertility; personalized care
(This special issue belongs to the Section Obstetrics & Gynecology)
Weaning from Non-Invasive Mechanical Ventilation Approaches (NIV-NHF): Insights on How, When and Where submission deadline 25 Nov 2025 | 2 articles | Viewed by 10101
Keywords: non-invasive positive pressure ventilation (NIPPV); nasal high flow oxygen; respiratory failure; intensive care units; pneumology wards; non-invasive mechanical ventilation approaches (NIV nasal high flow)
(This special issue belongs to the Section Intensive Care)
Recent Advances in Spine Tumor Diagnosis and Treatment
edited by Jae Hwan Cho
submission deadline 25 Nov 2025 | 8 articles | Viewed by 8947
Keywords: spine tumor; spinal metastasis; pathologic fracture; cord compression; separation surgery; radiotherapy; interdisciplinary collaboration; surgeon’ s role; medical oncologist; radiologic oncologist; psychological aspects; pain management; innovative approaches; patient outcomes; diagnostic advancements
(This special issue belongs to the Section Clinical Neurology)
Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition submission deadline 25 Nov 2025 | 5 articles | Viewed by 8841
Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radiotherapy; systemic treatment; quality of life
(This special issue belongs to the Section Obstetrics & Gynecology)
Cystic Fibrosis: Novel Strategies of Diagnosis and Treatments
edited by and
submission deadline 25 Nov 2025 | 6 articles | Viewed by 7955
Keywords: cystic fibrosis; CFTR modulators; stop mutations; gene therapy; mRNA therapy; novel therapies; rare pathogens
(This special issue belongs to the Section Respiratory Medicine)
A Multi-Faceted Approach to Urinary Incontinence and Other Pelvic Floor Dysfunction—from Prevention to Therapy submission deadline 25 Nov 2025 | 3 articles | Viewed by 7745
Keywords: urinary incontinence; pelvic floor dysfunction; urinary and fecal incontinence; pelvic organs prolapse; pelvic pain; pelvic floor disorders
(This special issue belongs to the Section Nephrology & Urology)
Cardiothoracic Surgery and Enhanced Recovery: Recent Advances and Perspectives
edited by Edris A.F. Mahtab
submission deadline 25 Nov 2025 | 4 articles | Viewed by 7326
Keywords: coronary artery bypass surgery; valve repair/replacement; minimally invasive cardiac procedures; aortic dissection repair; thoracic aortic aneurysm surgery; lung transplantation; ventricular assist devices; esophagectomy; lung surgery; heart transplantation; use of XR and AI in Enhanced recovery
(This special issue belongs to the Section General Surgery)
Advances in Dry Eye Disease Treatment: 2nd Edition
edited by and
submission deadline 25 Nov 2025 | 3 articles | Viewed by 7011
Keywords: dry eye disease; meibomian gland; tear substitutes; corticosteroids; cyclosporin; antibiotics; non-steroid anti-inflammatory drugs; biological tear substitutes; nutrients; pulsed light
(This special issue belongs to the Section Ophthalmology)
New Perspectives in Lumbar Spine Surgery: Treatment and Management
edited by
submission deadline 25 Nov 2025 | 4 articles | Viewed by 6401
Keywords: lumbar surgery; spine surgery; minimally invasive techniques; advanced imaging; surgical innovations; patient outcomes; evidence-based practices; postoperative care; rehabilitation strategies; surgical management
(This special issue belongs to the Section Orthopedics)
Research and Applications in Clinical Pharmacy Based on Pharmacokinetics and Pharmacogenetics
edited by
submission deadline 25 Nov 2025 | 3 articles | Viewed by 5913
Keywords: pharmacokinetics; clinical pharmacy; personalized medicine; drug therapy management; therapeutic drug monitoring
(This special issue belongs to the Section Pharmacology)
Advanced Techniques for the Treatment of Complex Coronary Artery Disease: 2nd Edition
edited by Simone Calcagno
submission deadline 25 Nov 2025 | 3 articles | Viewed by 5669
Keywords: coronary calcified lesion; IVUS; OCT; intravascular lithotripsy; bifurcation coronary lesions; left main; chronic total occlusions; multivessel disease; STEMI; NSTEMI
(This special issue belongs to the Section Cardiovascular Medicine)
Novel Insights into the Diagnosis and Management of Inflammatory Bowel Disease (IBD)
edited by
submission deadline 25 Nov 2025 | 4 articles | Viewed by 3839
Keywords: inflammatory bowel disease; non-invasive biomarkers; abdominal ultrasonography; colonoscopy; biologic therapy; small molecules; mucosal healing; brain-gut axis; dysbiosis; colorectal dysplasia
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Developments and Emerging Trends in Aortic Surgery
edited by Daniele Linardi
submission deadline 25 Nov 2025 | 4 articles | Viewed by 3835
Keywords: aortic aneurysm; aortic dissection; endovascular repair; minimally invasive approaches; thoracic aorta; abdominal aorta; aortic valve-sparing surgery; aortic stent grafts
(This special issue belongs to the Section Vascular Medicine)
Assessing Strategies and Challenges in Heart Failure: An Update
edited by
submission deadline 25 Nov 2025 | 2 articles | Viewed by 3592
Keywords: cardiac MR; coronary microvascular dysfunction; diagnosis; endothelial function; heart failure; myocardial metabolism; prognosis
(This special issue belongs to the Section Cardiology)
Recent Advances in Intracranial Aneurysm Treatment
edited by Victor Volovici
submission deadline 25 Nov 2025 | 2 articles | Viewed by 3389
Keywords: intracranial aneurysm; cerebrovascular disease; microneurosurgery; endovascular treatment; subarachnoid hemorrhage
(This special issue belongs to the Section Clinical Neurology)
Vascular Surgery: Current Advances and Future Directions
edited by Giovanni Coppi
submission deadline 25 Nov 2025 | 2 articles | Viewed by 2621
Keywords: stroke; carotid artery stenosis; carotid artery stenting; carotid endarterectomy; occlusion
(This special issue belongs to the Section General Surgery)
Recent Developments and Emerging Trends of Echocardiography in Cardiac Disease
edited by Petri Gudmundsson
submission deadline 25 Nov 2025 | 2 articles | Viewed by 2603
Keywords: echocardiography development; artificial intelligence (AI) integration; real-time 3D and 4D imaging; portable and handheld devices; contrast-enhanced imaging; tissue characterization; integration with other modalities; quantitative analysis; tele-echocardiography
(This special issue belongs to the Section Cardiology)
Modern Blood Banking and Transfusion in Clinical Practice: Second Edition
edited by
submission deadline 25 Nov 2025 | 2 articles | Viewed by 1890
Keywords: blood transfusion therapy; patient blood management; restrictive transfusion; cell therapy; platelet transfusion
(This special issue belongs to the Section Hematology)
Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1595
Keywords: pancreas surgery; liver resection; minimal invasive approach; virtual reality; robotic surgery; MDT
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Treatment and Prognosis of Spinal Surgery
edited by Andy Ton and Shane Shahrestani
submission deadline 25 Nov 2025 | 2 articles | Viewed by 1579
Keywords: spinal surgery; minimally invasive surgery (MIS); robotic-assisted surgery; patient-reported outcomes (PROs); postoper-ative outcomes; predictive analytics; radiographic predictors; endoscopic; disk arthroplasty; single position surgery
(This special issue belongs to the Section Clinical Neurology)
Hospital-Acquired Infections in the Elderly
edited by Nadya Kagansky and Emily Lubart
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1271
Keywords: hospital-acquired infections (HAIs); elderly patients; infection control; microbial resistance; epidemiology; risk factors; prevention strategies; treatment options; diagnostic accuracy
(This special issue belongs to the Section Epidemiology & Public Health)
Endometriosis: Current Insights and Treatments
edited by Mercedes Espada Vaquero
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1220
Keywords: endometriosis; chronic pelvic pain; pelvic floor dysfunction; hormonal treatment; gynecological surgery; diagnosis; hysteroscopy; infertility
(This special issue belongs to the Section Obstetrics & Gynecology)
Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis
edited by Borut Geršak and Robert Phillip Gallegos
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1040
Keywords: aortic stenosis; minimally invasive surgery; transcatheter aortic valve replacement; surgical treatment; diagnostic strategies; re-operation/redo AVR; calcified root; valve in valve
(This special issue belongs to the Section Cardiology)
New Insights in Paediatric Endocrinology
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 490
Keywords: endocrinology; pediatrics; hormones; therapy and treatment; adolescents; newborns
(This special issue belongs to the Section Clinical Pediatrics)
Ischemic Stroke: Diagnosis, Treatment, and Management
edited by and Rosario Pascarella
submission deadline 25 Nov 2025 | Viewed by 457
Keywords: ischemic stroke; diagnosis; treatment; stroke unit; stroke care; stroke etiology; thrombolysis; EVT; rare causes of stroke; cerebral vein thrombosis
(This special issue belongs to the Section Clinical Neurology)
Recent Advances in Diagnosis and Treatment of Comorbid Disorders in Interstitial Lung Diseases
edited by and Domenica Francesca Mariniello
submission deadline 25 Nov 2025 | Viewed by 243
Keywords: interstitial lung disease; ILD; progressive pulmonary fibrosis; artificial intelligence; management
(This special issue belongs to the Section Respiratory Medicine)
Enhancing Safety and Outcomes in Complex Spine Surgery
edited by Ahmed Ramadan Sadek
submission deadline 25 Nov 2025 | Viewed by 235
Keywords: spinal surgery; spinal deformity; scoliosis; sciatica; back and neck pain
(This special issue belongs to the Section Clinical Neurology)
Minimally Invasive Laparoendoscopic Procedures in Abdominal Emergencies submission deadline 25 Nov 2025 | Viewed by 194
Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; hepatobiliary surgery; pancreatic surgery; gastrointestinal surgery; general surgery; emergency surgery; trauma; recent advances in laparoscopic surgery; surgical training in laparoscopy; endoscopic surgery; the feasibility and safety of laparoscopic; endoscopic co-operative surgery for the treatment of digestive pathology
(This special issue belongs to the Section General Surgery)
Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications
edited by Ioanna Koniari
submission deadline 25 Nov 2025 | Viewed by 182
Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system
(This special issue belongs to the Section Cardiology)
Treatment and Digital Outcome Assessment in Orthopaedic Trauma
edited by Benedikt Johannes Braun and
submission deadline 25 Nov 2025 | Viewed by 134
Keywords: orthopaedic trauma; digital outcome assessment; wearable sensors; patient-reported outcomes; machine learning (or artificial intelligence)
(This special issue belongs to the Section Orthopedics)
New Approaches in Open and Minimally Invasive Surgery for Abdominal Oncologic Surgery
edited by and Immacolata Iannone
submission deadline 25 Nov 2025 | Viewed by 122
Keywords: surgical oncology; early diagnosis; minimally invasive surgery; personalized medicine; combined therapy; gastrointestinal cancer; oligometastatic cancer; peritoneal disease
(This special issue belongs to the Section General Surgery)
Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery submission deadline 27 Nov 2025 | 1 articles | Viewed by 176 | Submission Open
Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology
(This special issue belongs to the Section Otolaryngology)
Management of Complex Infective Endocarditis
edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas
submission deadline 27 Nov 2025 | Viewed by 114 | Submission Open
Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation
(This special issue belongs to the Section Cardiology)
Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition
edited by Tsutomu Yasukawa
submission deadline 28 Nov 2025 | 10 articles | Viewed by 11585 | Submission Open
Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium
(This special issue belongs to the Section Ophthalmology)
New Trends in Mechanical Ventilation
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 7441 | Submission Open
Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance
(This special issue belongs to the Section Anesthesiology)
Current Practices in Cardiovascular Perfusion and Recovery
edited by
submission deadline 28 Nov 2025 | 1 articles | Viewed by 2841 | Submission Open
Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation
(This special issue belongs to the Section Cardiology)
Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition
edited by Alexandre Hardy and Nicolas Bouguennec
submission deadline 28 Nov 2025 | 3 articles | Viewed by 2427 | Submission Open
Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure
(This special issue belongs to the Section Sports Medicine)
Clinical Updates in Heart Transplantation
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 1558 | Submission Open
Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease
(This special issue belongs to the Section Cardiology)
Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care submission deadline 28 Nov 2025 | Viewed by 247 | Submission Open
Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine
(This special issue belongs to the Section Respiratory Medicine)
State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery
edited by and Konstantinos Bramis
submission deadline 28 Nov 2025 | 1 articles | Viewed by 178 | Submission Open
Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract
edited by and Hubert Zatorski
submission deadline 28 Nov 2025 | Viewed by 131 | Submission Open
Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Challenges in Maternal-Fetal Medicine
edited by Marzena Laskowska
submission deadline 29 Nov 2025 | 7 articles | Viewed by 17015 | Submission Open
Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Critical Care Medicine
edited by Pietro Caironi
submission deadline 30 Nov 2025 | 14 articles | Viewed by 49502 | Submission Open
Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma
(This special issue belongs to the Section Intensive Care)
Recent Advances in Reconstructive Urology and Prosthetic Surgery
edited by Francisco E. Martins, Maurice Garcia and Jay Simhan
submission deadline 30 Nov 2025 | 5 articles | Viewed by 15629 | Submission Open
Keywords: male and female urogenital reconstruction; urologic trauma; urologic prosthetics; erectile dysfunction; urinary incontinence; artificial urinary sphincter; gender-affirming surgery; transgender; phalloplasty; vaginoplasty
(This special issue belongs to the Section Nephrology & Urology)
What’s New in Cardiomyopathies: Diagnosis, Treatment and Management
edited by
submission deadline 30 Nov 2025 | 6 articles | Viewed by 15093 | Submission Open
Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases
(This special issue belongs to the Section Cardiology)
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