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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Acute Myocardial Infarction: Clinical Advances in Prognostic Stratification, Diagnosis, and Treatment

edited by

Matteo Armillotta

Luca Bergamaschi

and

Carmine Pizzi

submission deadline 29 Jan 2026 | 6 articles | Viewed by 9868

Keywords: acute myocardial infarction (AMI); atherosclerosis; ST segment elevation myocardial infarction (STEMI); non-ST elevation myocardial infarction (NSTEMI); acute coronary syndrome (ACS); prognosis; coronary CT angiography (CCTA); cardiac magnetic resonance (CMR); reperfusion therapy; antiplatelet therapy

(This special issue belongs to the Section Cardiology)

Cerebral Palsy: Clinical Rehabilitation and Treatment

edited by Joav Merrick and

Dilipkumar R. Patel

submission deadline 30 Jan 2026 | 7 articles | Viewed by 20581 | Submission Open

Keywords: cerebral palsy; physiotherapy; occupational therapy; orthopedic management; medical management; rehabilitation approaches

(This special issue belongs to the Section Clinical Neurology)

New Advances in Cardiorenal Syndrome: 2nd Edition

edited by

Rainer Ullrich Pliquett

submission deadline 30 Jan 2026 | 5 articles | Viewed by 19783 | Submission Open

Keywords: cardiorenal syndrome; outcome; hyperkalemia; acute kidney injury; chronic kidney disease; chronic heart failure

(This special issue belongs to the Section Cardiology)

Current Advances in General and Regional Anesthesia

edited by Eleni Laou, Eleana Garini and Giolanda Varvarousi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3636 | Submission Open

Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety

(This special issue belongs to the Section Anesthesiology)

Advances in Minimally Invasive Surgery: Transformative Technologies, Techniques and Trends

edited by Michail Pitiakoudis

submission deadline 30 Jan 2026 | 3 articles | Viewed by 2687 | Submission Open

Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical innovation; hernia repair; colorectal surgery; gastrointestinal surgery; hepatopancreatobiliary surgery; surgical simulation; virtual reality; augmented reality; artificial intelligence; surgical training; patient outcomes; surgical oncology

(This special issue belongs to the Section General Surgery)

Mind–Body Connection: The Impact of Mental Health on Physical Well-Being

edited by

Mario Pinto

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2580 | Submission Open

Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare

(This special issue belongs to the Section Mental Health)

Insights on Cancer Diagnosis, Treatment and Side Effects Management

edited by

Octav Ginghină

Mihai-Teodor Georgescu

and

Laurentia Nicoleta Gales

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1672 | Submission Open

Keywords: cancer diagnosis; cancer treatment; side effects management; oncology; personalized medicine; supportive care

(This special issue belongs to the Section Oncology)

Clinical Outcomes in Bipolar and Depressive Disorders

edited by

Luca J. Steardo

and Francesco Monaco

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1260 | Submission Open

Keywords: mood disorders; clinical outcomes; treatment response; psychopathology; pathophysiology

(This special issue belongs to the Section Mental Health)

The Role of Biomarkers in Cardiovascular Diseases

edited by Giorgia Panichella

submission deadline 31 Jan 2026 | 6 articles | Viewed by 9508 | Submission Open

Keywords: biomarkers; cardiovascular diseases; heart failure; ischemic heart disease; cardiomyopathy; risk stratification; diagnosis; prognosis; inflammation

(This special issue belongs to the Section Cardiovascular Medicine)

Causes and Advanced Treatments of Macular Edema

edited by

Gawęcki Maciej

and

Slawomir Teper

submission deadline 31 Jan 2026 | 4 articles | Viewed by 9346 | Submission Open

Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT

(This special issue belongs to the Section Ophthalmology)

Acute Coronary Syndromes: Clinical Advances in Diagnosis and Treatment

edited by Pierre Sabouret,

Giuseppe Andò

and

Elad Asher

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5247 | Submission Open

Keywords: acute coronary syndromes; myocardial infarction; cardiac biomarkers; antiplatelet therapy; revascularization; precision medicine; risk stratification

(This special issue belongs to the Section Cardiology)

Management of Ligaments and Tendons Injuries

edited by Vivek Kumar Morya

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3135 | Submission Open

Keywords: tendinopathy; ligaments; tendons; anterior cruciate ligament (ACL); rotator cuff

(This special issue belongs to the Section Orthopedics)

Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments

edited by

Niccola Funel

, Paolo Domenico Parchi and Andrea del Chiaro

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2802 | Submission Open

Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis; osteoarthritis; musculoskeletal disorder; pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches

(This special issue belongs to the Section Orthopedics)

Revolutionizing Neurosurgery: Cutting-Edge Techniques and Innovations

edited by

Yoichi Morofuji

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2606 | Submission Open

Keywords: neuroendovascular surgery; neuroimaging; neurosurgery; neuroendoscopic surgery

(This special issue belongs to the Section Clinical Neurology)

Pushing Boundaries in Cardiac Resynchronization Therapy: Clinical Innovations Transforming Heart Failure Management

edited by István Szokodi and

Attila Kónyi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2412 | Submission Open

Keywords: cardiac resynchronization therapy; heart failure; pacing strategies; patient selection; multi-point pacing; clinical innovations; nonresponders

(This special issue belongs to the Section Cardiology)

Cardiothoracic and Vascular Anesthesia—Clinical Management and Challenges

edited by Marko Zdravković and

Vlatka Sotosek

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1626 | Submission Open

Keywords: cardiac anesthesia; thoracic anesthesia; vascular anesthesia; innovation; perioperative medicine; healthcare; outcomes; challenges

(This special issue belongs to the Section Anesthesiology)

Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care

edited by

Konstantinos Stathogiannis

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1151 | Submission Open

Keywords: TAVI; TAVR; MTEER; TTEER; TTVR; ASD; PFO; IVUS; OCT

(This special issue belongs to the Section Cardiology)

Clinical Updates on Dyslipidemia

edited by

Nathan Wong

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1136 | Submission Open

Keywords: dyslipidemia; cardiovascular disease; prevention; treatment; risk factors

(This special issue belongs to the Section Cardiovascular Medicine)

Diagnosis and Treatment of Aortic Dissection: Experts' Views

edited by Marja K Hedman and Annastiina Husso

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1122 | Submission Open

Keywords: aortic diseases; aortic type A dissection; aortic growth rate; aortic length; aortic imaging

(This special issue belongs to the Section Cardiology)

Artificial Intelligence and Machine Learning in Clinical Practice

edited by Theodosis Kalamatianos and

Ioannis Kakkos

submission deadline 31 Jan 2026 | Viewed by 462 | Submission Open

Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis

(This special issue belongs to the Section General Surgery)

Application of Artificial Intelligence in Gastric Cancer

edited by

Lorena Torroni

and

Maria Bencivenga

submission deadline 31 Jan 2026 | Viewed by 296 | Submission Open

Keywords: artificial intelligence (AI); gastric cancer; AI-assisted endoscopy; radiomics; robotic surgery; gastrointestinal diseases; digital pathology; translational research; innovation in healthcare

(This special issue belongs to the Section Oncology)

Clinical Management and Update of Aortic Dissection and Aortic Aneurysm Diseases

edited by

Makoto Hibino

submission deadline 31 Jan 2026 | Viewed by 194 | Submission Open

Keywords: aortic aneurysm; aortic dissection; aortic surgery; endovascular procedures

(This special issue belongs to the Section Cardiovascular Medicine)

Strategies to Optimize Efficiency of Clear Aligners and Fixed Appliances in the Digital Orthodontics Era

edited by

Maciej Jedliński

submission deadline 31 Jan 2026 | Viewed by 186 | Submission Open

Keywords: clear aligners; fixed orthodontic appliances; digital orthodontics; orthodontic treatment planning; tooth movement efficiency; patient-centered care; treatment modality selection

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Anesthesia and Pain Management for Women: 2nd Edition

edited by Gaetano Draisci and Stefano Catarci

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: anesthesia; women; gender differences; acute pain; chronic pain; hormonitoring; pain perception; fibromyalgia; migraine; monitoring; obstetrics; cesarean section; gynecologic surgery

(This special issue belongs to the Section Anesthesiology)

Skin Cancer: From Diagnosis to Personalized Treatment

edited by

Anthony J. Dixon

submission deadline 31 Jan 2026 | Viewed by 139 | Submission Open

Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery

(This special issue belongs to the Section Dermatology)

Exercise, Injury and Rehabilitation: Integrated Perspectives in Sports Medicine

edited by

Cíntia França

and

Élvio Gouveia

submission deadline 3 Feb 2026 | 2 articles | Viewed by 7542 | Submission Open

Keywords: sports medicine; biomechanics; injury prevention; exercise physiology; sports performance; load management; exercise prescription; return to play; recovery

(This special issue belongs to the Section Sports Medicine)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) as a Global but Not Liver-Limited Health Challenge—from Disease Pathogenesis to Therapeutic Targets

edited by

Beata Kasztelan-Szczerbinska

and Halina Cichoż-Lach

submission deadline 5 Feb 2026 | 4 articles | Viewed by 11152 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); non-alcoholic fatty liver disease (NAFLD); hepatic steatosis; multiorgan metabolic interactions; liver-related morbidity; liver-related mortality; lipid metabolism; cardiovascular metabolic complications; metabolic dysfunction-related cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances and Clinical Outcomes of Cardiothoracic Surgery

edited by Hee-Jung Kim and

Seung-Hyun Lee

submission deadline 5 Feb 2026 | Viewed by 257 | Submission Open

Keywords: cardiac surgery; coronary artery bypass grafting; heart valve surgery; aortic intervention; materials; precision medicine; artificial intelligence

(This special issue belongs to the Section General Surgery)

Physical Therapy in Neurorehabilitation: Innovations, Challenges and Opportunities

edited by

Daphne Bakalidou

Maria Gabriella Ceravolo

and

Pinelopi Vlotinou

submission deadline 6 Feb 2026 | Viewed by 186 | Submission Open

Keywords: neurorehabilitation; physical activity; neurocognitive rehabilitation; neurogenic bladder; fatigue; sexual dysfunction; accessibility

(This special issue belongs to the Section Clinical Neurology)

Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era, 3rd Edition

edited by

Adolfo Di Fiore

and

Giulia Brunello

submission deadline 10 Feb 2026 | 6 articles | Viewed by 18967 | Submission Open

Keywords: 3D printing; additive manufacturing; milling technologies; CAD/CAM; digital implant planning; digital workflow; facial scanners; computer-guided implant surgery; intraoral scanners; digital design and fabrication of dental prostheses

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates and Perspectives of Implant Dentistry

edited by

Renzo Guarnieri

and

Rodolfo Reda

submission deadline 10 Feb 2026 | 4 articles | Viewed by 14603 | Submission Open

Keywords: osseointegration; soft tissue integration; peri-implant diseases

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | 3 articles | Viewed by 7899 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section Infectious Diseases)

The Journey of Hearing and Hearing-Related Disorders over Time—2nd Edition

edited by

Winfried Schlee

and

Jorge Piano Simões

submission deadline 10 Feb 2026 | 4 articles | Viewed by 6995 | Submission Open

Keywords: hearing; hearing journey; hearing-related disorders; tinnitus; hyperacusis; digital phenotyping; big data

(This special issue belongs to the Section Otolaryngology)

Plastic and Reconstructive Surgery: Cutting-Edge Expert Perspective

edited by

Roberto Cuomo

and

Ishith Seth

submission deadline 10 Feb 2026 | 2 articles | Viewed by 3056 | Submission Open

Keywords: plastic and reconstructive surgery; new perspectives; regeneration; microsurgery; oncoplastic; post bariatric; breast implant

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Challenges and Advancements in Lateral Skull Base Surgery

edited by Alessia Rubini

submission deadline 10 Feb 2026 | 2 articles | Viewed by 2755 | Submission Open

Keywords: lateral skull base; neurotology; jugular foramen; cerebellopontine angle; petrous apex; inner ear; acoustic neuroma; jugular paraganglioma; transtemporal approaches; infratemporal approaches

(This special issue belongs to the Section Otolaryngology)

Application of Anticoagulation and Antiplatelet Therapy

edited by

Rossella Marcucci

and

Martina Berteotti

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1990 | Submission Open

Keywords: antiplatelets; anticoagulants; atherothrombosis; coronary artery disease; peripheral artery disease; cerebral artery disease; vitamin K antagonists; direct oral anticoagulants; clopidogrel; aspirin; ticagrelor; prasugrel

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Pediatric Critical Care Medicine

edited by

Lama Elbahlawan

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1877 | Submission Open

Keywords: acute renal failure; acute respiratory failure; pediatric oncology; pediatric ICU; pediatric critical care medicine; multi-organ dysfunction

(This special issue belongs to the Section Clinical Pediatrics)

Advancements and Future Directions in Clinical Psychosis

edited by

Marco Colizzi

and

Alessandra Martinelli

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1688 | Submission Open

Keywords: clinical psychosis; schizophrenia spectrum disorders; early detection of psychosis; treatment-resistant psychosis; long-term outcomes; personalized psychiatry; digital mental health; AI in psychiatry; neurocognitive interventions; psychosocial therapies; translational psychiatry; interdisciplinary mental health; psychosis clinical trials; innova-tive diagnostic tools

(This special issue belongs to the Section Mental Health)

Management of Congenital Heart Disease (CHD)

edited by Sarah Nordmeyer and Marie Schafstedde

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1491 | Submission Open

Keywords: congenital heart disease; imaging; diagnostics; surgical innovations; minimally invasive interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Hearing Disorders: Diagnosis, Management, and Future Opportunities: 4th Edition

edited by

George K. Psillas

submission deadline 10 Feb 2026 | 2 articles | Viewed by 926 | Submission Open

Keywords: middle ear surgery; otosclerosis; sensorineural hearing loss; sudden hearing; cochlear implant

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in Spine Disorders—2nd Edition

edited by

Sokol Trungu

and

Luca Ricciardi

submission deadline 10 Feb 2026 | 1 articles | Viewed by 561 | Submission Open

Keywords: spine disorders; lumbar spine surgery; minimally invasive surgery; spine surgery; microneurosurgery

(This special issue belongs to the Section Clinical Neurology)

Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional Cell Carcinoma: Current Evidence

edited by

Massimiliano Creta

submission deadline 10 Feb 2026 | Viewed by 308 | Submission Open

Keywords: extracorporeal shock wave lithotripsy; lasers; percutaneous lithotripsy; robotic surgery; ureteroscopy; urolithiasis

(This special issue belongs to the Section Nephrology & Urology)

Recent Concepts in Ovarian Cancer: Epidemiology, Diagnosis, Treatment and Quality of Life

edited by Giulia Scotto and

Giorgio Valabrega

submission deadline 10 Feb 2026 | Viewed by 167 | Submission Open

Keywords: ovarian cancer; quality of life; multidisciplinary care; personalized medicine; PARP inhibitors

(This special issue belongs to the Section Oncology)

Clinical Advances in Pain Management

edited by Jamal Hasoon and Omar Viswanath

submission deadline 13 Feb 2026 | 11 articles | Viewed by 23030 | Submission Open

Keywords: postoperative pain; acute pain; chronic pain; nociceptive; analgesia; analgesics; interventional pain procedures

(This special issue belongs to the Section Anesthesiology)

Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations

edited by Giuseppe Barilaro

submission deadline 15 Feb 2026 | 4 articles | Viewed by 5425 | Submission Open

Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies

(This special issue belongs to the Section Immunology & Rheumatology)

Periodontal Diseases and Systemic Health: Pathogenesis, Prevention and Management

edited by

Saverio Cosola

submission deadline 15 Feb 2026 | 3 articles | Viewed by 5372 | Submission Open

Keywords: periodontitis; dental implants; systemic inflammation; diabetes and periodontal disease; cardiovascular implications; pregnancy and oral health; host immune responses; preventive dentistry; implant-prosthetic rehabilitation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances

edited by

Cristian George Ţieranu

and

Adrian Saftoiu

submission deadline 15 Feb 2026 | 1 articles | Viewed by 3750 | Submission Open

Keywords: pancreatic disorder; pancreatitis; pancreatic cancer; translational research; diagnosis; treatment

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiac Electrophysiology: Focus on Clinical Practice

edited by

Andreas Müssigbrodt

submission deadline 15 Feb 2026 | 4 articles | Viewed by 3718 | Submission Open

Keywords: cardiomyopathy; arrhythmia; heart rhythm; atrial fibrillation; ventricular tachycardia; sudden cardiac death; mapping; ablation; pulsed field ablation (PFA); device; pacemaker; left bundle branch area pacing (LBBAP); conduction system pacing (CSP); implantable cardioverter-defibrillator (ICD); leadless pacing; extraction

(This special issue belongs to the Section Cardiology)

New Insight into Pain and Chronic Pain Management

edited by

Eung Don Kim

submission deadline 15 Feb 2026 | 2 articles | Viewed by 3138 | Submission Open

Keywords: chronic pain; pain management; pharmacological treatment; non-pharmacological interventions; neuromodula-tion; multidisciplinary approaches; personalized medicine; quality of life

(This special issue belongs to the Section Clinical Rehabilitation)

Bariatric Surgery: Challenges and Future Trends

edited by Hugo Santos-Sousa

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2840 | Submission Open

Keywords: obesity; metabolic and bariatric surgery; sleeve gastrectomy; metabolic syndrome; novel surgical procedures; Nissen-sleeve fundoplication; Roux-en-Y gastric bypass distalization; single-anastomosis procedures

(This special issue belongs to the Section General Surgery)

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