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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Spinal Muscular Atrophy: Pathogenesis, Diagnosis, Therapeutics and Future Directions

edited by

Dinko Vitezić

Andrej Belančić

and Valentino Rački

submission deadline 15 Nov 2025 | 1 articles | Viewed by 2355 | Submission Open

Keywords: genetic diseases; neuromuscular disorders; rare diseases; spinal muscular atrophy; survival motor neuron protein

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

“The Power of Light” in Biomedical and Pharmaceutics: New Approaches for Photodynamic Purposes

edited by

Lucinda V. Reis

and

Eurico Lima

submission deadline 20 Nov 2025 | Viewed by 208 | Submission Open

Keywords: light; photosensitizers; photochemistry; photobiology; photodynamic therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Head and Neck Cancer

edited by

Yu-Ming Wang

and

Sheng-Dean Luo

submission deadline 29 Nov 2025 | 3 articles | Viewed by 6062 | Submission Open

Keywords: modern therapeutic approach; nasopharyngeal carcinoma; head and neck cancer; particle therapy; cancer survivorship; sinonasal cancer

(This special issue belongs to the Section Molecular and Translational Medicine)

The End of the COVID-19 Pandemic—What Is Currently Known and What Could Have Been Useful Four Years Ago? (2nd Edition)

edited by

Monika Zajkowska

and

Monika Gudowska-Sawczuk

submission deadline 30 Nov 2025 | 18 articles | Viewed by 45397 | Submission Open

Keywords: COVID-19; SARS-CoV-2; pandemic; diagnosis; biomarkers; treatment; immunity; inflammation; cytokines; vaccine

(This special issue belongs to the Section Molecular and Translational Medicine)

Dopamine Signaling Pathway in Health and Disease—2nd Edition

edited by

Floriana Volpicelli

Maria Concetta Miniaci

and

Luisa Speranza

submission deadline 30 Nov 2025 | 9 articles | Viewed by 27353 | Submission Open

Keywords: differentiation; disease modeling ; dopamine and drugs; gene expression; human stem cells; neuronal development; reprogramming; signaling pathways; neurodegeneration; neuromodulation

(This special issue belongs to the Section Molecular and Translational Medicine)

Progress in Neurodevelopmental Disorders Research

edited by

Catarina Morais Seabra

submission deadline 30 Nov 2025 | 6 articles | Viewed by 24511 | Submission Open

Keywords: neurodevelopmental disorders; autism spectrum disorder; attention deficit hyperactivity disorder

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Diagnostic and Therapeutic Approaches in Diabetic Microvascular Complications, 2nd Edition

edited by

Ana Maria Dascalu

and

Dragos Serban

submission deadline 30 Nov 2025 | 6 articles | Viewed by 21485 | Submission Open

Keywords: diabetic retinopathy; diabetic foot ulcer; inflammatory biomarkers; microbiota; novel therapies

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Acute and Chronic Heart Failure: Pathophysiology and New Therapeutic Developments, 2nd Edition

edited by

Serafino Fazio

and Valentina Mercurio

submission deadline 30 Nov 2025 | 15 articles | Viewed by 20644 | Submission Open

Keywords: heart failure with reduced ejection fraction; heart failure with preserved ejection fraction; pathophysiological novelties; treatment advances; pulmonary arterial hypertension; at-home follow-up of patients with heart failure

(This special issue belongs to the Section Molecular and Translational Medicine)

Women’s Special Issue Series: Biomedicines (2nd Edition)

edited by

Letizia Polito

Federica Falà

and

Riuko Ohashi

submission deadline 30 Nov 2025 | 6 articles | Viewed by 18358 | Submission Open

Keywords: antibody; biomedicines; biopharmaceutical products; cancer therapy; drug delivery; immunoconjugates; immunotoxins; immunotherapy; immunotargeting; nanodelivery; toxins

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews on Cardiovascular and Metabolic Diseases

edited by

Cristiana Bustea

submission deadline 30 Nov 2025 | 4 articles | Viewed by 13216 | Submission Open

Keywords: cardiovascular diseases; metabolic diseases; global health; disease prevention; innovative treatments

(This special issue belongs to the Section Cell Biology and Pathology)

The Neuropharmacology of Cannabinoids: Developments in Medicine

edited by

Tibor Markus Brunt

submission deadline 30 Nov 2025 | 1 articles | Viewed by 13010 | Submission Open

Keywords: THC; CBD; cannabis; endocannabinoid system; therapeutic; disease; health

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Neonatal Disease: From Pathophysiology to Current and Emerging Therapeutic Approaches (2nd Edition)

edited by

Fumihiko Namba

submission deadline 30 Nov 2025 | 8 articles | Viewed by 12676 | Submission Open

Keywords: fetal therapy; neonatal diseases; pathophysiology; innovative therapeutic approaches

(This special issue belongs to the Section Cell Biology and Pathology)

Ovarian Physiology and Reproduction

edited by Atefeh Najafi

submission deadline 30 Nov 2025 | 5 articles | Viewed by 10535 | Submission Open

Keywords: ovarian physiology; female fertility; folliculogenesis; oocyte; hormonal regulation; endocrine disruptors; ovarian aging; genetic modifications; environmental factors and female fertility; female reproductive health and disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

The Development of Cancer Immunotherapy

edited by

Satoshi Wada

submission deadline 30 Nov 2025 | 4 articles | Viewed by 10028 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; genetically modified T-cell therapy; hematological cancers; solid tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

Wound Healing: From Mechanisms to Therapeutic Approaches

edited by

Stefano Bacci

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9755 | Submission Open

Keywords: wound healing; acute wounds; chronic wounds; keloids; hypertrophic scar; therapies; photobiomodulation; neuroimmunomodulation

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights into Bone and Cartilage Biology

edited by Vincent Yuan

submission deadline 30 Nov 2025 | 5 articles | Viewed by 9596 | Submission Open

Keywords: bone remodeling; cartilage degeneration; osteoporosis; osteoarthritis; mitochondrial function; protein modifications; immune signaling; therapeutic strategies

(This special issue belongs to the Section Molecular and Translational Medicine)

Emerging Trends in Gastrointestinal Tract Disease Therapies

edited by

Puo-Hsien Le

, Jenwei Chou and

Chen-Shuan Chung

submission deadline 30 Nov 2025 | 2 articles | Viewed by 8668 | Submission Open

Keywords: gut microbiota; fecal microbiota transplantation; inflammatory bowel disease; advanced endoscopy; endoscopic bariatric therapy; endoscopic anti-reflux therapy natural orifice transluminal endoscopic surgery; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Extracellular Vesicles for Diagnosis and Treatment of Human Diseases

edited by

Zoran Minic

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8294 | Submission Open

Keywords: human diseases; extracellular vesicles; biomarkers; diagnosis; prognosis; therapeutic targets; therapeutic applications; EV engineering; physiology; pathology

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights and Latest Advances in Corneal and Ocular Surface Diseases

edited by Isabella M. Y. Cheung and Akilesh Gokul

submission deadline 30 Nov 2025 | 6 articles | Viewed by 7730 | Submission Open

Keywords: corneal disease; ocular surface disease prevention; diagnosis; management; pathobiology; epidemiology; health service delivery

(This special issue belongs to the Section Molecular and Translational Medicine)

Tendinopathy and Myopathy: From Molecular Basis to Therapy

edited by

Simon Fuk-Tan Tang

and Carl Pai Chu Chen

submission deadline 30 Nov 2025 | 2 articles | Viewed by 7155 | Submission Open

Keywords: musculoskeletal disorder; tendinopathy; myopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Genitourinary Cancer

edited by Jue Wang

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6950 | Submission Open

Keywords: genitourinary (GU) cancer; prostate; bladder; kidney; and testicular cancer; diagnosis; treatment; pathogenesis; precision medicine; biomarker discovery; genomic profiling

(This special issue belongs to the Section Molecular and Translational Medicine)

Colorectal Cancer: Diagnostic, Pathophysiology and Therapeutic Approaches

edited by

Antonio Biondi

and

Marco Vacante

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6847 | Submission Open

Keywords: colorectal cancer; biomarkers; chemotherapy; immunotherapy; liquid biopsy; endoscopy; surgery; microbiota; screening

(This special issue belongs to the Section Cancer Biology and Oncology)

Neuroinflammation and Neuroprotection

edited by

Brandon Lucke-Wold

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6517 | Submission Open

Keywords: neuroinflammation; neurodegeneration; mechanisms; disease progression; ER stress; oxidative stress; mitochondrial dysfunction

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Novel Insights into Liver Metabolism

edited by

Agata Michalak

and

Halina Cichoż-Lach

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6502 | Submission Open

Keywords: liver; metabolism; oxidative stress; mi-RNAs; cirrhosis; alcohol-related liver disease; autoimmune liver disorders; hepatocellular cancer; liver steatosis; microbiota; diagnostic markers

(This special issue belongs to the Section Endocrinology and Metabolism Research)

From Bench to Bedside: Advances in Non-small Cell Lung Cancer in the Era of Precision Oncology

edited by Iyare Izevbaye

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5912 | Submission Open

Keywords: non-small-cell lung cancer; precision medicine; liquid biopsy; biomarkers; predictive modeling; comprehensive genomic profiling; biomarkers; immuno-oncology; lung cancer biology

(This special issue belongs to the Section Cancer Biology and Oncology)

Connections Between Diabetes Mellitus, Other Metabolic and Endocrine Dysfunctions and Cardiovascular Pathologies—Second Edition

edited by

Cristina Tudoran

and Dragos Cozma

submission deadline 30 Nov 2025 | 7 articles | Viewed by 5790 | Submission Open

Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; thyroid dysfunction; hormonal alterations; endothelial dysfunction; coronary artery disease; hypertension; peripheric arterial disease

(This special issue belongs to the Section Endocrinology and Metabolism Research)

The Art of ART (Assisted Reproductive Technologies)

edited by

Dimitrios Papageorgiou

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5143 | Submission Open

Keywords: assisted reproductive technologies; infertility diagnosis; intrauterine insemination (IUI); intracytoplasmic sperm injection (ICSI); in vitro fertilization (IVF); embryo implantation; oocyte quality; preimplantation genetic testing; mitochondrial replacement therapy; follicular recruitment; reproductive medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Bioinformatics Analysis of RNA for Human Health and Disease

edited by Jihwan Ha

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5039 | Submission Open

Keywords: bioinformatics; computational biology; machine learning; multi-omics data analysis; biomarker detection; biomedical AI convergence; medical and public health informatics; RNA sequencing (RNA-Seq); functional genomics; RNA-protein interactions; experimental validation of biomarkers; RNA structural biology; transcriptome-wide association studies (TWAS); gene expression profiling; RNA modifications (e.g.; m6A; pseudouridylation); in vitro and in vivo RNA functional studies; single-cell RNA analysis; RNA therapeutics development

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Mechanisms and Therapeutic Strategies of Brain and Spinal Cord Injury

edited by

Hatice Kumru

and Xabier Urra

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5029 | Submission Open

Keywords: brain injury; spinal cord injury; stem cells; gene therapy; neuromodulation techniques

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Skin Diseases: From Molecular Mechanisms to Novel Therapeutic Approaches

edited by

Guangtong Deng

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4924 | Submission Open

Keywords: skin diseases; cell death; ferroptosis; cuproptosis; melanoma; cancer immunotherapy; psoriasis

(This special issue belongs to the Section Molecular and Translational Medicine)

Animal Models of Neurological Disorders: Where Are We Now? (3rd Edition)

edited by

Marc Ekker

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4783 | Submission Open

Keywords: animal model of neurological disorders; Parkinson’ s disease; Alzheimer’ s disease; epilepsy; seizures; Huntington’ s disease; schizophrenia

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Diagnostics and Therapy for Malignant Tumors: New Developments

edited by

Chan-Yen Kuo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4649 | Submission Open

Keywords: metabolites; immunity; microbiome; microenvironment; inflammation

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurodegeneration No More: Cutting-Edge Technologies and Therapies in the Evolution of Neurodegenerative Disease Management—2nd Edition

edited by

Masaru Tanaka

Simone Battaglia

and

Donato Liloia

submission deadline 30 Nov 2025 | 5 articles | Viewed by 4545 | Submission Open

Keywords: Alzheimer’ s disease; frontotemporal lobar degeneration; Parkinson’ s disease; aging decline; mild cognitive impairment; multiple sclerosis; stroke; acquired brain damage; altered cognitive processes; brain functional impairment; neurocognitive disorders; cognitive; behavioral; and functional disorders; acquired trauma; brain plasticity and connectivity; non-invasive brain stimulation; diagnosis and treatment; functional evidence of altered cognition and connectivity; blood-based biomarkers; disease heterogeneity; prognosis; protein aggregation; inflammation; oxidative stress; medicinal plants; phytocompounds

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Animal Models for Neurological Disease Research

edited by

Sreeja Sarasamma

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4328 | Submission Open

Keywords: animal models; neurological diseases; genetic models; CRISPR/Cas9; transgenic organisms; behavioral analysis; neurodegeneration; single-cell approaches; zebrafish; lamprey; biocomputational approaches; gene therapy; pharmacological interventions; translational neurobiology; disease pathways

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Reproductive Endocrinology and Fertility: From Bench to Bedside

edited by

Myung Joo Kim

submission deadline 30 Nov 2025 | 1 articles | Viewed by 4199 | Submission Open

Keywords: reproductive health; reproductive system diseases; hormonal regulation; infertility; reproductive dysfunction; reproductive genetics; reproductive physiology; assisted reproductive technologies

(This special issue belongs to the Section Molecular and Translational Medicine)

Bench-to-Bedside Approach to Migraine: How Pathophysiology Could Influence Novel Therapeutic Approaches and Back

edited by Alessandro Vigano and Matteo Castaldo

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4125 | Submission Open

Keywords: migraine; comorbidities; pathophysiology; pharmacological interventions; non-pharmacological interventions; chronicization; neurophysiological or neuroimaging for disability or clinical response

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Genomics and Bioinformatics of Human Disease

edited by

Sankarasubramanian Jagadesan

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3980 | Submission Open

Keywords: genomics; bioinformatics; precision medicine; single-cell RNA sequencing; genetic variations; cellular heterogeneity; AI/ML; pathogenicity prediction

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Brain Tumor Diagnosis: Innovations and Emerging Technologies

edited by

Mubarak Taiwo Mustapha

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3570 | Submission Open

Keywords: brain tumor diagnosis; artificial intelligence in oncology; deep learning in medical imaging; machine learning models; predictive analytics in healthcare; digital pathology; glioma detection; multi-modal data integration; neuro-oncology; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Exploring Human Diseases Through Genomic and Genetic Analyses

edited by Fernando Regateiro and

Henriqueta Silva

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3485 | Submission Open

Keywords: genomic and genetic analyses; genomic medicine; personalized medicine; technologies and testing methods; complex diseases; monogenic diseases; pharmacogenomics

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advanced Research in Pulmonary Pathophysiology

edited by Ourania S. Kotsiou and Erasmia Rouka

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3303 | Submission Open

Keywords: pathophysiology; aging; disease; injury; microbiome; small airways; pleura; lung cancer; infections; critical care

(This special issue belongs to the Section Cell Biology and Pathology)

The Role of Iron in Human Diseases

edited by Margherita Correnti

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3265 | Submission Open

Keywords: iron metabolism; iron dysregulation; diseases; iron deficiency; iron overload

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Periodontal Disease and Periodontal Tissue Regeneration—Second Edition

edited by

Irina-Georgeta Sufaru

and

Sorina Mihaela Solomon

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3212 | Submission Open

Keywords: periodontal diagnosis; periodontal immunology; periodontal microbiology; periodontal tissue regeneration; tissue engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Pediatric Tumors: Diagnosis, Pathogenesis, Treatment, and Outcome

edited by Hermann L. Müller

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3032 | Submission Open

Keywords: pediatric oncology; leukemia; sarcoma; brain tumor; chemotherapy; irradiation; targeted therapy; sequelae

(This special issue belongs to the Section Cancer Biology and Oncology)

Role of Natural Product in Cardiovascular Disease—2nd Edition

edited by

Jian Li

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2937 | Submission Open

Keywords: nature products; phytochemicals; biological and pharmacological activity; cardiovascular disease (CVD) pathogenesis of CVD; risk factors of CVD; metabolic symptom; clinical or preclinical studies

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Coronary Artery Disease: From Pathophysiology to Therapeutic Strategies

edited by

Pawel Nadziakiewicz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2800 | Submission Open

Keywords: pathophysiological concept of coronary artery disease; coronary microvascular dysfunction; chronic coronary syndrome; acute coronary syndrome; post-acute coronary syndrome with heart failure; diagnostics in coronary artery disease; therapeutic strategies in CAD; revascularization

(This special issue belongs to the Section Cell Biology and Pathology)

Thoracic Malignancies: From Pathophysiology to Novel Therapeutic Approaches

edited by Yanyun Gao

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2679 | Submission Open

Keywords: thoracic malignancies; lung cancer; esophageal cancer; pleural mesothelioma (PM); molecular subtypes; drug resistance; target therapy; biomarkers; immunotherapy; preclinical models

(This special issue belongs to the Section Cancer Biology and Oncology)

Two Decades of Advances in Colorectal Cancer Prevention and Treatment: From Aspirin to Precision Oncology

edited by

Manish Tripathi

and

Puneet Vij

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2482 | Submission Open

Keywords: immunotherapy; biomarkers; colorectal cancer; targeted therapies; molecular pathways

(This special issue belongs to the Section Cancer Biology and Oncology)

Non-Invasive Brain Stimulation Techniques and Their Application in the Study of Cognitive Function Physiology and Neuro-Psychiatric Rehabilitation

edited by

Mattia Ferro

Jacopo Lamanna

and Andrea Stefano Moro

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2150 | Submission Open

Keywords: non-invasive brain stimulation; neurophysiology; cognitive function; depression; schizophrenia

(This special issue belongs to the Section Molecular and Translational Medicine)

Inflammatory Bowel Diseases: New Diagnostic and Therapeutic Approaches—Second Edition

edited by

Maria Manuela Estevinho

and

Fernando Magro

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2143 | Submission Open

Keywords: bowel inflammation; Crohn’ s disease; endoscopy; inflammatory bowel disease; targeted therapy; ulcerative colitis

(This special issue belongs to the Section Immunology and Immunotherapy)

Molecular Research of Neurological and Psychiatric Disorders

edited by

Yuen Gao

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1915 | Submission Open

Keywords: molecular biology; neurodegenerative disorders; psychiatry; biomarkers; therapeutic targets

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

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