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Commentary
Peer-Review Record

Tardive Dyskinesia and Dopamine Oxidation, Cumulative Effects

J 2019, 2(2), 138-141; https://doi.org/10.3390/j2020011
by James David Adams, Jr.
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
J 2019, 2(2), 138-141; https://doi.org/10.3390/j2020011
Submission received: 12 March 2019 / Revised: 27 March 2019 / Accepted: 29 March 2019 / Published: 31 March 2019

Round 1

Reviewer 1 Report

This is an improved version from the first submission of this editorial comment regarding the potential role of oxidative stresss on the role of D2 anti-psychotics in contributing to tardive dyskinisia in Schizophrenic patients.


I have a few suggestions to add:


It would be good to talk about the extrapyramidal effects of D2 anti-psychotics (e.g. chemical-induced Parkinsonism) which can be equally detrimental and develop first before tardive dyskinesia.

The link of dopamine turnover and oxidative stress to tardive dyskinesia is still weak. Only one paper was cited which described in vivo work (Andreassen et al., 2000). More papers need to be referenced regarding the role of oxidative stress in contributing to tardive dyskinesia.

Author Response

I have added some discussion of extrapyramidal effects of D2 blockers.

I have added 2 references and more discussion about dopamine turnover and oxygen radicals.


Reviewer 2 Report

My previous comments were not adequately addressed. There is e.g. no addition or explanation on my concern regarding the added value to the existing literature. 

Author Response

The editorial underlines the importance of tardive dyskinesia as a drug side effect.  I believe it is an important issue.

Reviewer 3 Report

The review paper has improved significantly after revision. I recommend it for publication.

Author Response

Thank you.


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