Action Potential Firing Induces Sodium Transients in Macroglial Cells of the Mouse Corpus Callosum
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals, Tissue Preparation, and Salines
2.2. Sodium Imaging and Electrophysiology
2.3. Immunohistochemistry
2.4. SDS-PAGE and Western Blot
2.5. Data Analysis and Presentation
3. Results
3.1. Action Potentials Evoke Sodium Transients in Macroglial Cells of the Corpus Callosum
3.2. Pharmacology of Action Potential-Induced Sodium Transients in Macroglial Cells
3.3. Relevance of Gap Junctional Coupling
3.4. Relevance of Different Glutamate Transporter Subtypes
3.5. Spatial and Developmental Expression Profile of Glutamate-Aspartate-Transporter and Glutamate Transporter-1 in Corpus Callosum
4. Discussion
4.1. Action Potentials Induce Sodium Transients in White Matter Glial Cells That Are Related to Glutamate
4.2. Relevance of Different Sodium Influx Pathways
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Moshrefi-Ravasdjani, B.; Ziemens, D.; Pape, N.; Färfers, M.; Rose, C.R. Action Potential Firing Induces Sodium Transients in Macroglial Cells of the Mouse Corpus Callosum. Neuroglia 2018, 1, 106-125. https://doi.org/10.3390/neuroglia1010009
Moshrefi-Ravasdjani B, Ziemens D, Pape N, Färfers M, Rose CR. Action Potential Firing Induces Sodium Transients in Macroglial Cells of the Mouse Corpus Callosum. Neuroglia. 2018; 1(1):106-125. https://doi.org/10.3390/neuroglia1010009
Chicago/Turabian StyleMoshrefi-Ravasdjani, Behrouz, Daniel Ziemens, Nils Pape, Marcel Färfers, and Christine R. Rose. 2018. "Action Potential Firing Induces Sodium Transients in Macroglial Cells of the Mouse Corpus Callosum" Neuroglia 1, no. 1: 106-125. https://doi.org/10.3390/neuroglia1010009