Next Article in Journal
The Special Case of Human Astrocytes
Previous Article in Journal
Remembering Ben Barres
Article Menu

Export Article

Open AccessPerspective
Neuroglia 2018, 1(1), 7-20; https://doi.org/10.3390/neuroglia1010003

Interlaminar Glia and Other Glial Themes Revisited: Pending Answers Following Three Decades of Glial Research

Unit of Applied Neurobiology (UNA, CEMIC-CONICET), Buenos Aires 1053, Argentina
Received: 23 January 2018 / Revised: 20 February 2018 / Accepted: 22 February 2018 / Published: 1 March 2018
Full-Text   |   PDF [6038 KB, uploaded 20 July 2018]   |  

Abstract

This review aims to highlight the various significant matters in glial research stemming from personal work by the author and associates at the Unit of Applied Neurobiology (UNA, CEMIC-CONICET), and some of the pending questions. A reassessment and further comments on interlaminar astrocytes—an astroglial cell type that is specific to humans and other non-human primates, and is not found in rodents, is presented. Tentative hypothesis regarding their function and future possible research lines that could contribute to further the analysis of their development and possible role(s), are suggested. The possibility that they function as a separate entity from the “territorial” astrocytes, is also considered. In addition, the potential significance of our observations on interspecies differences in in vitro glial cell dye coupling, on glial diffusible factors affecting the induction of this glial phenotype, and on their interference with the cellular toxic effects of cerebrospinal fluid obtained from l-DOPA treated patients with Parkinson´s disease, is also considered. The major differences oberved in the cerebral cortex glial layout between human and rodents—the main model for studying glial function and pathology—calls for a careful assessment of known and potential species differences in all aspects of glial cell biology. This is essential to provide a better understanding of the organization and function of human and non-human primate brain, and of the neurobiological basis of their behavior. View Full-Text
Keywords: interlaminar astrocytes; role(s) of interlaminar astrocytes; control of interlaminar glia development; thalamic regulation of interlaminar glia; comparative dye coupling; glial diffusible factors interlaminar astrocytes; role(s) of interlaminar astrocytes; control of interlaminar glia development; thalamic regulation of interlaminar glia; comparative dye coupling; glial diffusible factors
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Colombo, J.A. Interlaminar Glia and Other Glial Themes Revisited: Pending Answers Following Three Decades of Glial Research. Neuroglia 2018, 1, 7-20.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Neuroglia EISSN 2571-6980 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top