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Proceedings 2017, 1(4), 552; doi:10.3390/proceedings1040552

LED-Based Tomographic Imaging for Live-Cell Monitoring of Pancreatic Islets in Microfluidic Channels

1
Institute of Semiconductor Technology (IHT), TU Braunschweig, D-38106 Braunschweig, Germany
2
Laboratory for Emerging Nanometrology (LENA), TU Braunschweig, D-38106 Braunschweig, Germany
3
Institute of Pharmacology, Toxicology and Clinical Pharmacy (IPT), TU Braunschweig, D-38106 Braunschweig, Germany
4
Institute of Microtechnology (IMT), TU Braunschweig, D-38124 Braunschweig, Germany
5
MIND-IN2UB, Department of Engineering: Electronics, University of Barcelona, E-08028 Barcelona, Spain
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 22 August 2017
Download PDF [709 KB, uploaded 22 August 2017]

Abstract

A portable lensless imaging device combining light-emitting diodes (LEDs) and a CMOS image sensor was developed and its suitability for non-invasive live-cell in vitro monitoring of pancreatic islets was demonstrated. A microfluidic lab-on-a-chip platform containing micro wells with various depths was also fabricated and integrated into the optical sensor system, which allows for immobilization of the single islets and continuous recording of their behavior. This promising technique may provide further insight into the structure and function of pancreatic islets and their deficiencies in type 2 diabetes.
Keywords: holographic microscopy; LED; CMOS image sensor; microfluidics; tomography holographic microscopy; LED; CMOS image sensor; microfluidics; tomography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Scholz, G.; Xu, Q.; Schulze, T.; Boht, H.; Mattern, K.; Hartmann, J.; Dietzel, A.; Scherneck, S.; Rustenbeck, I.; Prades, J.D.; Fündling, S.; Wasisto, H.S.; Waag, A. LED-Based Tomographic Imaging for Live-Cell Monitoring of Pancreatic Islets in Microfluidic Channels. Proceedings 2017, 1, 552.

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