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Proceedings 2017, 1(4), 516; doi:10.3390/proceedings1040516

Study on Cell-Capturing Microfluidic Device in High Flow Rates through Controlling Shape of Microstructures and Their Alignments

1
Biomedical IT Fusion Department, Electronics and Telecommunications Research Institute (ETRI), Daejeon, Korea
2
Department of Laboratory Medicine, Eulji University Hospital, Daejeon, Korea
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 22 August 2017
Download PDF [527 KB, uploaded 22 August 2017]

Abstract

A new cell-trapping method for single cell analysis devices at a very rapid flow rate, is designed, fabricated and characterized by controlling shapes of microstructures and their arrangements in array just simply and effectively within the microfluidic channels. We simulated using a commercialized computational fluidic dynamic simulator (CFD-ACE+) and demonstrated experimentally that the cell-capturing rate enhanced over three times and a high capturing efficiency of about 70% at a 300 µL/min at the cross-arranged left-turned isosceles trapezoid. The device is applicable for a tool in the field of characterization of rare cells, personal medicine, and prognostic of disease.
Keywords: microfluidic device; rare cell capturing; shape control; high flow rate microfluidic device; rare cell capturing; shape control; high flow rate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, D.-S.; Park, J.W.; Jung, M.Y.; Ihm, C. Study on Cell-Capturing Microfluidic Device in High Flow Rates through Controlling Shape of Microstructures and Their Alignments. Proceedings 2017, 1, 516.

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