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Proceedings 2017, 1(4), 517; doi:10.3390/proceedings1040517

Monitoring Biological Cell Flow within a Mimicking Capillary Device with Impedance Measurement

1
SATIE, UMR CNRS 8029, ENS Paris Saclay, Cachan, France
2
BIGR, UMR_S 1134, INTS, Paris, France
3
ESIEE-Paris, ESYCOM EA 2552, Noisy-Le-Grand, France
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 17 August 2017
Download PDF [1184 KB, uploaded 17 August 2017]

Abstract

This paper presents a microfluidic system, characterizing the red blood cell (RBC) deformability through its transit time in a microchannel, which dimensions reproducing blood microcirculation capillary. Electrodes are integrated within the microchannel for electrical measurements. The transit time is measured with the electrical blockade produced when the RBC squeezes in the microchannel (d = 5 μm diameter, while the cell diameter is 8 μm). In order to determine most suitable electrical frequency range for the voltage applied to excitation electrodes, FEM numerical simulation of the bioimpedance is achieved and presented in this paper. We investigated the frequency response of the bioimpedance taking into account the electrode polarization, the dielectric properties of the medium, a single shell model for RBC and finally the RBC position within the microchannel.
Keywords: microfluidic; bioimpedance; sickle cell disease; mimetic chip microfluidic; bioimpedance; sickle cell disease; mimetic chip
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tieying, X.; Lizarralde, M.; Nemer, W.E.; Pioufle, B.L.; Français, O. Monitoring Biological Cell Flow within a Mimicking Capillary Device with Impedance Measurement. Proceedings 2017, 1, 517.

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