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Proceedings 2017, 1(4), 514; doi:10.3390/proceedings1040514

Development of a Novel Platelets Functional Assay Using QCM

1
Department of Physical Chemistry, Faculty for Chemistry, University of Vienna, Währinger Strasse 42, 1090 Vienna, Austria
2
Austrian Red Cross, Blood Program, Blood Service for Vienna, Lower Austria and Burgenland, Wiedner Hauptstrasse 32, 1041 Vienna, Austria
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 29 August 2017
Download PDF [439 KB, uploaded 29 August 2017]

Abstract

Thrombocytes and their metabolites are involved in numerous physiological and pathophysiological processes, such as blood coagulation at the site of ruptured endothelium. Normal platelet aggregation can be suppressed via platelet antagonists or non-steroidal anti-inflammatory drugs (NSAIDs). That’s why differentiating between resting (“normal”) and inhibited platelets in a quick and precise fashion could be of a great clinical significance. Herein, we present the first step on the way to a novel platelet functionality assay based on Molecularly Imprinted Polymers (MIP) coated onto Quartz Crystal Microbalance (QCM). First results reveal sensor responses that depend on platelet concentration and on incubation of platelets with aspirin: acetyl salicylic acid (AAS).
Keywords: molecularly imprinted polymers; MIP; QCM; thrombocytes; acetyl salicylic acid molecularly imprinted polymers; MIP; QCM; thrombocytes; acetyl salicylic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Strallhofer, A.E.; Jung, S.; Jungbauer, C.; Lieberzeit, P.A. Development of a Novel Platelets Functional Assay Using QCM. Proceedings 2017, 1, 514.

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