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Proceedings 2017, 1(10), 1044; doi:10.3390/proceedings1101044

Cytotoxic Effects of Functional Foods Momordica charantia L. and Lycium barbarum L. Extracts on Prostate Cancer Cells

1
Department of Biochemistry, Faculty of Pharmacy, Erciyes University, 38000 Kayseri, Turkey
2
Faculty of FoodEngineering, Erciyes University, 38000 Kayseri, Turkey
3
Department of Pharmaceutical Botany, Faculty of Pharmacy, Erciyes University, 38000 Kayseri, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 17 November 2017
Download PDF [165 KB, uploaded 17 November 2017]

Abstract

Prostate cancer is a growing health problem around the world. Although there are different therapeutic methods, none of them possessed complete efficacy up to now. Therefore, discovery of novel anti-cancer drugs is important. Bitter melon (Momordicacharantia L.) and Goji berry (Lycium barbarum L.) as functional foods may prevent prostate cancer. In this study, we investigated the effects of ripe and unripe fruit (peel and pulp), seed and aril extracts of bitter melon and also black and red fruit extracts of L. Barbarum on cancer cell viability. In vitro cytotoxicity activities of the extracts (0–150 µg/mL) against androgen dependent (LnCAP) and independent (PC-3) prostate cancer cell lines were screened by MTT assay. Our results reveal that, all tested extracts exhibited cytotoxic activity towards the investigated tumour cells and bitter melon seed extract was the most effective extracts having an IC50 value of 14.7 µg/mL for LnCAP cells. The overall findings demonstrate that specially seed extract of bitter melon, could be a potential source of a new anti-cancer compound and serve as a possible drug against prostate cancer.
Keywords: Bitter melon; goji berry; cytotoxic activity Bitter melon; goji berry; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Basaran, G.S.; Bekci, H.; Baldemir, A.; İlgün, S.; Cumaoğlu, A. Cytotoxic Effects of Functional Foods Momordica charantia L. and Lycium barbarum L. Extracts on Prostate Cancer Cells. Proceedings 2017, 1, 1044.

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