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Proceedings 2017, 1(10), 1034; doi:10.3390/proceedings1101034

The Effect of Herbal Medicine on Prostate Cancer Cells in Culture

1
Department of Histology & Embryology, Faculty of Medicine, Manisa Celal Bayar University, 45000 Manisa, Turkey
2
Faculty of Science and Literature, Biology, Manisa Celal Bayar University, 45000 Manisa, Turkey
3
Department of Histology & Embryology, Faculty of Medicine, İzmir University of Economics,35330 İzmir, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 17 November 2017
Download PDF [164 KB, uploaded 17 November 2017]

Abstract

Herbal medicine has been used historically for anticancer effect and potent antiproliferative effects on different cancer cell lines. Prostate cancer has become the most common malignancy and the second highest cause of cancer death Western world. The antioxidant, antidepressant and antimicrobial effect of Viscum album, Inula viscosa, Hypericum perforatum, Lysimachia nummularia, Oleocanthal, Pinus pinaster and Rubus caeisus on cancer cell lines. In this study, we investigated whether these seven plants show any anticancer properties on prostat cancer cell line. Du145 cancer cells and human adipose tissue derived mesenchymal stem cell were assessed for seven medical plants in culture with different doses. Firstly, the cytotoxicity rate (IC50) determined by MTT and then immunocytochemical procedure were done for oxidative stress (eNOS), angiogenesis (VEGF) and TUNEL method for apoptosis. The stainings were evaluated by H-score. According to the results, Inula viscosa and Rubus caeisus have a higher improvement effect than the other medicinal plants. And these plants were not toxic for adipose tissue derived mesenchymal stem cells. These plants caused the inhibition of cell proliferation and apoptosis in prostat cancer cells. Our results indicated that these plants may be potential agents in prostat cancer treatment.
Keywords: Du 145; Herbal Medicine; Tunnel Du 145; Herbal Medicine; Tunnel
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Toros, P.; Şen, B.; Sönmez, P.K.; Özkut, M.; Öztürk, Ş.; Çöllü, F.; İnan, S.; Tuğlu, İ. The Effect of Herbal Medicine on Prostate Cancer Cells in Culture. Proceedings 2017, 1, 1034.

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