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Vision 2017, 1(3), 20; doi:10.3390/vision1030020

CD40, a Novel Inducer of Purinergic Signaling: Implications to the Pathogenesis of Experimental Diabetic Retinopathy

1
Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
2
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Academic Editor: Tetsuya Sugiyama
Received: 18 July 2017 / Revised: 8 August 2017 / Accepted: 9 August 2017 / Published: 12 August 2017
(This article belongs to the Special Issue Purinergic Receptors in the Eye)
View Full-Text   |   Download PDF [628 KB, uploaded 12 August 2017]   |  

Abstract

Diabetic retinopathy is a leading complication of diabetes. Death of capillary cells with resulting capillary degeneration is a central feature of this disease. Chronic low-grade inflammation has been linked to the development of retinal capillary degeneration in diabetes. CD40 is an upstream inducer of a broad range of inflammatory responses in the diabetic retina and is required for death of retinal capillary cells. Recent studies uncovered CD40 as a novel inducer of purinergic signaling and identified the CD40-ATP-P2X7 pathway as having a key role in the induction of inflammation in the diabetic retina and programmed cell death of retinal endothelial cells. View Full-Text
Keywords: diabetes; retina; Müller cells; endothelial cells; inflammation; cell death diabetes; retina; Müller cells; endothelial cells; inflammation; cell death
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Subauste, C.S. CD40, a Novel Inducer of Purinergic Signaling: Implications to the Pathogenesis of Experimental Diabetic Retinopathy. Vision 2017, 1, 20.

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