Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues
AbstractA series of diverse substituted 5-methyl-isoxazole-4-carboxylic acid amides, imide and esters in which the benzene ring is mono or disubstituted was prepared. Spectroscopic and conformational examination was investigated and a new insight involving steric interference and interesting downfield deviation due to additional diamagnetic anisotropic effect of the amidic carbonyl group and the methine protons in 2,6-diisopropyl-aryl derivative (2) as conformationaly restricted analogues Leflunomide was discussed. Individual substituent electronic effects through π resonance of p-substituents and most stable conformation of compound (2) are discussed. View Full-Text
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Henen, M.A.; Hamdi, A.; Farahat, A.A.; Massoud, M.A.M. Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues. Magnetochemistry 2017, 3, 41.
Henen MA, Hamdi A, Farahat AA, Massoud MAM. Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues. Magnetochemistry. 2017; 3(4):41.Chicago/Turabian Style
Henen, Morkos A.; Hamdi, Abdelrahman; Farahat, Abdelbasset A.; Massoud, Mohammed A.M. 2017. "Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues." Magnetochemistry 3, no. 4: 41.
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