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Gels, Volume 7, Issue 1

2021 March - 32 articles

Cover Story: Adenocarcinoma of the colon is the most common malignant neoplasia of the gastrointestinal tract and is a major contributor to mortality worldwide. Current therapies forecast total resection of primary tumor when possible and partial liver resection at advanced stages, along with systemic intravenous therapies consisting of chemotherapeutic agents. These cures are definitely not exempt from drawbacks and heavy side effects. Biocompatible hydrogels, in bulk and colloid forms, which can load a variety of molecules, are suitable for this purpose and tunable to individual patient scheduling, shortening side effects. Moreover, they do not require surgical removal, thanks to spontaneous degradation, and guarantee an extended cargo release, maintaining high chemotherapeutic concentrations. View this paper
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Articles (32)

  • Review
  • Open Access
23 Citations
5,564 Views
15 Pages

Biopolymers Hybrid Particles Used in Dentistry

  • I-Hao Chen,
  • Tzer-Min Lee and
  • Chih-Ling Huang

22 March 2021

This literature review provides an overview of the fabrication and application of biopolymer hybrid particles in dentistry. A total of 95 articles have been included in this review. In the review paper, the common inorganic particles and biopolymers...

(This article belongs to the Special Issue Biopolymer Gel-Assisted Synthesis of Particles for Biomedical Applications)
  • Article
  • Open Access
13 Citations
3,655 Views
19 Pages

22 March 2021

Experiments on swelling and solute transport in polymeric systems clearly indicate that the classical parabolic models fail to predict typical non-Fickian features of sorption kinetics. The formulation of moving-boundary transport models for solvent...

(This article belongs to the Special Issue Gels: 6th Anniversary)
  • Review
  • Open Access
208 Citations
19,990 Views
28 Pages

Cellulose-Based Hydrogels for Wastewater Treatment: A Concise Review

  • Maimuna Akter,
  • Maitry Bhattacharjee,
  • Avik Kumar Dhar,
  • Fahim Bin Abdur Rahman,
  • Siddika Haque,
  • Taslim Ur Rashid and
  • S M Fijul Kabir

18 March 2021

Finding affordable and environment-friendly options to decontaminate wastewater generated with heavy metals and dyes to prevent the depletion of accessible freshwater resources is one of the indispensable challenges of the 21st century. Adsorption is...

  • Article
  • Open Access
11 Citations
3,684 Views
11 Pages

Local Use of Hydrogel with Amiodarone in Cardiac Surgery: Experiment and Translation to the Clinic

  • Vladimir Shvartz,
  • Teymuraz Kanametov,
  • Maria Sokolskaya,
  • Andrey Petrosyan,
  • Tatyana Le,
  • Olga Bockeria and
  • Leo Bockeria

10 March 2021

The objective of this study was to study the use of the hydrogel biopolymer based on sodium alginate (“Colegel”) with a drug substance—amiodarone—for the prevention of postoperative atrial fibrillation (POAF) in cardiac surgery. The experimental part...

  • Article
  • Open Access
21 Citations
4,401 Views
17 Pages

5 March 2021

The delivery of multiple anti-cancer agents holds great promise for better treatments. The present work focuses on developing multifunctional materials for simultaneous and local combinatory treatment: Chemotherapy and hyperthermia. We first produced...

(This article belongs to the Collection Feature Papers in Gel Materials)
  • Article
  • Open Access
24 Citations
5,909 Views
13 Pages

Evaluation of Polyurea-Crosslinked Alginate Aerogels for Seawater Decontamination

  • Patrina Paraskevopoulou,
  • Grigorios Raptopoulos,
  • Faidra Leontaridou,
  • Maria Papastergiou,
  • Aikaterini Sakellari and
  • Sotirios Karavoltsos

4 March 2021

Polyurea-crosslinked Ca-alginate (X-Ca-alginate) aerogel beads (diameter: 3.3 mm) were evaluated as adsorbents of metal ions, organic solvents, and oils. They were prepared via reaction of an aromatic triisocyanate (Desmodur RE) with pre-formed Ca-al...

(This article belongs to the Special Issue Aerogels 2020)
  • Article
  • Open Access
28 Citations
7,536 Views
17 Pages

Microemulsions as Solubilizers and Penetration Enhancers for Minoxidil Release from Gels

  • Miroslava Špaglová,
  • Mária Čuchorová,
  • Martina Čierna,
  • Silvester Poništ and
  • Katarína Bauerová

3 March 2021

Micro- and nanoemulsions are potential drug solubilizers and penetration enhancers through the high surfactant/co-surfactant content. This study aimed to evaluate the influence of minoxidil (MXD) solubilized in the microemulsions (MEs) on drug releas...

  • Article
  • Open Access
12 Citations
6,968 Views
14 Pages

Effect of Nonlinear Elasticity on the Swelling Behaviors of Highly Swollen Polyelectrolyte Gels

  • Jian Tang,
  • Takuya Katashima,
  • Xiang Li,
  • Yoshiro Mitsukami,
  • Yuki Yokoyama,
  • Ung-il Chung,
  • Mitsuhiro Shibayama and
  • Takamasa Sakai

1 March 2021

Polyelectrolyte gels exhibit swelling behaviors that are dependent on the external environment. The swelling behaviors of highly charged polyelectrolyte gels can be well explained using the Flory–Rehner model combined with the Gibbs–Donnan effect and...

(This article belongs to the Special Issue Physicochemical and Mechanical Properties of Polymer Gels)
  • Review
  • Open Access
93 Citations
10,154 Views
61 Pages

Recently Developed Carbohydrate Based Gelators and Their Applications

  • Joedian Morris,
  • Jonathan Bietsch,
  • Kristen Bashaw and
  • Guijun Wang

26 February 2021

Carbohydrate based low molecular weight gelators have been an intense subject of study over the past decade. The self-assembling systems built from natural products have high significance as biocompatible materials and renewable resources. The versat...

  • Article
  • Open Access
20 Citations
5,831 Views
11 Pages

An On-Demand Dissoluble Chitosan Hydrogel Containing Dynamic Diselenide Bond

  • Xingxia Xu,
  • Weihong Lu,
  • Jian Zhu,
  • Xiangqiang Pan and
  • Xiulin Zhu

20 February 2021

A new kind of on-demand dissolution hydrogel is successfully synthesized by modification of chitosan using γ-selenobutyrolactone. The chitosan hydrogel with different selenium contents is formed by ring opening of γ-selenobutyrolactone with the amine...

  • Article
  • Open Access
11 Citations
6,257 Views
19 Pages

Polymer Networks Synthesized from Poly(Sorbitol Adipate) and Functionalized Poly(Ethylene Glycol)

  • Haroon Rashid,
  • Yury Golitsyn,
  • Muhammad Humayun Bilal,
  • Karsten Mäder,
  • Detlef Reichert and
  • Jörg Kressler

20 February 2021

Polymer networks were prepared by Steglich esterification using poly(sorbitol adipate) (PSA) and poly(sorbitol adipate)-graft-poly(ethylene glycol) mono methyl ether (PSA-g-mPEG12) copolymer. Utilizing multi-hydroxyl functionalities of PSA, poly(ethy...

(This article belongs to the Collection Feature Papers in Gel Materials)
  • Article
  • Open Access
29 Citations
5,297 Views
13 Pages

Fabrication and Evaluation of Silk Sericin-Derived Hydrogel for the Release of the Model Drug Berberine

  • Chi Yan,
  • Jianwei Liang,
  • Hao Fang,
  • Xizhi Meng,
  • Jiale Chen,
  • Zhi Zhong,
  • Qin Liu,
  • Hongmei Hu and
  • Xiaoning Zhang

20 February 2021

Silk sericin (SS) produced by Bombyx mori is normally discarded as waste in manufacturing processes, which causes environmental pollution. Therefore, investigating the use of silk sericin has economic and environmental benefits. As a three-dimensiona...

  • Review
  • Open Access
18 Citations
4,968 Views
17 Pages

Ion-Induced Volume Transition in Gels and Its Role in Biology

  • Matan Mussel,
  • Peter J. Basser and
  • Ferenc Horkay

18 February 2021

Incremental changes in ionic composition, solvent quality, and temperature can lead to reversible and abrupt structural changes in many synthetic and biopolymer systems. In the biological milieu, this nonlinear response is believed to play an importa...

(This article belongs to the Special Issue Polyelectrolyte Gels: Volume II)
  • Review
  • Open Access
11 Citations
5,546 Views
28 Pages

17 February 2021

We present a brief review of some important conceptual and practical aspects for the design and properties of molecular luminescent gelators and their gels. Topics considered include structural and dynamic aspects of the gels, including factors impor...

(This article belongs to the Collection Feature Papers in Gel Materials)
  • Article
  • Open Access
22 Citations
7,505 Views
10 Pages

Fast and Large Shrinking of Thermoresponsive Hydrogels with Phase-Separated Structures

  • Taehun Chung,
  • Im Kyung Han,
  • Jihoon Han,
  • Kyojin Ahn and
  • Youn Soo Kim

16 February 2021

Thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) hydrogels have been attracting attention in a variety of functional materials, such as biomaterials, because they exhibit a volume phase transition phenomenon near physiological temperatures. How...

(This article belongs to the Special Issue Physicochemical and Mechanical Properties of Polymer Gels)
  • Review
  • Open Access
36 Citations
12,937 Views
35 Pages

Modeling the Mechanobiology of Cancer Cell Migration Using 3D Biomimetic Hydrogels

  • Xabier Morales,
  • Iván Cortés-Domínguez and
  • Carlos Ortiz-de-Solorzano

12 February 2021

Understanding how cancer cells migrate, and how this migration is affected by the mechanical and chemical composition of the extracellular matrix (ECM) is critical to investigate and possibly interfere with the metastatic process, which is responsibl...

  • Article
  • Open Access
5 Citations
3,467 Views
26 Pages

5 February 2021

A convenient method for the preparation of polybasic ternary hybrid cryogels consisting of Halloysite nanotubes (HNTs) and tertiary amine functional groups by freezing-induced gelation is proposed. Ternary hybrid gels were produced via one-shot radic...

(This article belongs to the Special Issue Physicochemical and Mechanical Properties of Polymer Gels)
  • Article
  • Open Access
15 Citations
6,391 Views
9 Pages

In Vitro Evaluation of the Effect of a Not Cross-Linked Hyaluronic Acid Hydrogel on Human Keratinocytes for Mesotherapy

  • Nicola Zerbinati,
  • Sabrina Sommatis,
  • Cristina Maccario,
  • Maria Chiara Capillo,
  • Serena Di Francesco,
  • Raffaele Rauso,
  • Marina Protasoni,
  • Edoardo D’Este,
  • Daniela Dalla Gasperina and
  • Roberto Mocchi

4 February 2021

The multicomponent preparations for mesotherapy are based on the principle that skin and hair aging can be prevented by supplying the fundamental substrates for correct cellular functioning, such as nucleotides, vitamins, amino acids, and biomolecule...

(This article belongs to the Special Issue Hydrogels for Biomedical Applications: New Knowledge)
  • Review
  • Open Access
25 Citations
5,347 Views
14 Pages

Peptide Gelators to Template Inorganic Nanoparticle Formation

  • Ottavia Bellotto,
  • Maria C. Cringoli,
  • Siglinda Perathoner,
  • Paolo Fornasiero and
  • Silvia Marchesan

2 February 2021

The use of peptides to template inorganic nanoparticle formation has attracted great interest as a green route to advance structures with innovative physicochemical properties for a variety of applications that range from biomedicine and sensing, to...

  • Article
  • Open Access
26 Citations
10,836 Views
17 Pages

1 February 2021

Hydrogels have played a significant role in many applications of regenerative medicine and tissue engineering due to their versatile properties in realizing design and functional requirements. However, as bioengineered solutions are translated toward...

  • Article
  • Open Access
2 Citations
3,092 Views
13 Pages

Crossover of Rate-Limiting Process in Plasma Gel Growth by Contact with Source of Gelator

  • Akitsugu Kawabata,
  • Takao Yamamoto,
  • Hiroki Shinoda,
  • Kazuto Yoshiba,
  • Yoshiharu Toyama,
  • Susumu Tanaka and
  • Toshiaki Dobashi

28 January 2021

Plasma is regarded as a solution of precursor polymers specifically transformed to gel-forming polymers by a reaction with initiators. We developed a theory for the gel growth dynamics of plasma induced by contact with a source of gelators that are y...

  • Article
  • Open Access
35 Citations
5,891 Views
18 Pages

28 January 2021

Olive oil has recognized health benefits but lacks structural resilience to act in a similar fashion as do the typically used triglycerides (TAGs) when applied in food manufacturing. Therefore, olive oil structuring is critical to widening its use as...

  • Article
  • Open Access
87 Citations
9,684 Views
16 Pages

Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier

  • Muhammad Suhail,
  • Arshad Khan,
  • Jessica M Rosenholm,
  • Muhammad Usman Minhas and
  • Pao-Chu Wu

27 January 2021

The aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time. In this research work, sodium alginate-co-poly(2-acrylamido-2-methyl propane sulphon...

  • Article
  • Open Access
34 Citations
6,249 Views
20 Pages

Topical Mucoadhesive Alginate-Based Hydrogel Loading Ketorolac for Pain Management after Pharmacotherapy, Ablation, or Surgical Removal in Condyloma Acuminata

  • Salima El Moussaoui,
  • Francisco Fernández-Campos,
  • Cristina Alonso,
  • David Limón,
  • Lyda Halbaut,
  • Maria Luisa Garduño-Ramirez,
  • Ana Cristina Calpena and
  • Mireia Mallandrich

23 January 2021

Condyloma acuminata is an infectious disease caused by the human papilloma virus (HPV) and one of the most common sexually transmitted infections. It is manifested as warts that frequently cause pain, pruritus, burning, and occasional bleeding. Treat...

  • Review
  • Open Access
43 Citations
7,260 Views
21 Pages

22 January 2021

Cell therapy has the potential to regenerate cardiac tissue and treat a variety of cardiac diseases which are currently without effective treatment. This novel approach to treatment has demonstrated clinical efficiency, despite low retention of the c...

  • Review
  • Open Access
30 Citations
8,134 Views
28 Pages

Advances in Bio-Based Polymers for Colorectal Cancer Treatment: Hydrogels and Nanoplatforms

  • Anna Maspes,
  • Fabio Pizzetti,
  • Arianna Rossetti,
  • Pooyan Makvandi,
  • Giovanni Sitia and
  • Filippo Rossi

11 January 2021

Adenocarcinoma of the colon is the most common malignant neoplasia of the gastrointestinal tract and is a major contributor to mortality worldwide. Invasiveness and metastatic behavior are typical of malignant tumors and, because of its portal draina...

  • Article
  • Open Access
23 Citations
6,308 Views
13 Pages

Cellulose Nanofibrils/Xyloglucan Bio-Based Aerogels with Shape Recovery

  • Samuel Mandin,
  • Samuel Moreau,
  • Malika Talantikite,
  • Bruno Novalès,
  • Jean-Eudes Maigret,
  • Bernard Cathala and
  • Céline Moreau

5 January 2021

Bio-based aerogels containing cellulose nanofibrils (CNFs) are promising materials due to the inherent physical properties of CNF. The high affinity of cellulose to plant hemicelluloses (xyloglucan, xylan, pectin) is also an opportunity to develop bi...

(This article belongs to the Special Issue Aerogels 2020)
  • Article
  • Open Access
28 Citations
7,980 Views
16 Pages

5 January 2021

This work aims to contribute to the theoretical and experimental research of supercritical processes for intensification and combination in one apparatus. Investigation is carried out to improve production technology of organic alginate aerogels. It...

(This article belongs to the Special Issue Aerogels 2020)
  • Review
  • Open Access
36 Citations
8,321 Views
20 Pages

New Horizons in Hydrogels for Methotrexate Delivery

  • Ali Dehshahri,
  • Anuj Kumar,
  • Vijay Sagar Madamsetty,
  • Ilona Uzieliene,
  • Shima Tavakol,
  • Fereshteh Azedi,
  • Hojjat Samareh Fekri,
  • Ali Zarrabi,
  • Reza Mohammadinejad and
  • Vijay Kumar Thakur

30 December 2020

Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led re...

(This article belongs to the Special Issue Gels Horizons: From Science to Smart Materials)
  • Article
  • Open Access
7 Citations
4,768 Views
11 Pages

30 December 2020

In this contribution, a micro-mechanically based constitutive model is proposed to describe the nonlinear inelastic rubber-like features of alginate-based double network hydrogel cross-linked via various counterions. To this end, the lengthening of t...

(This article belongs to the Special Issue Modeling and Simulation of Gel-Based Materials)
  • Review
  • Open Access
29 Citations
6,975 Views
16 Pages

Fractal Structure in Silica and Composites Aerogels

  • Thierry Woignier,
  • Juan Primera,
  • Adil Alaoui,
  • Philippe Dieudonne,
  • Laurent Duffours,
  • Isabelle Beurroies,
  • Sylvie Calas-Etienne,
  • Florence Despestis,
  • Annelise Faivre and
  • Pascal Etienne

26 December 2020

Silica aerogels are known to be materials with exceptional characteristics, such as ultra-low density, high surface area, high porosity, high adsorption, and low-thermal conductivity. In addition, these unique properties are mainly related to their s...

(This article belongs to the Special Issue Aerogels 2020)
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Gels - ISSN 2310-2861