Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery
Abstract
:1. Introduction
2. Results and Discussion
2.1. AC-NPs Composite Systems Synthesis
2.2. Rhodamine Release
2.3. NPs Release from AC6 Hydrogel
2.4. NPs Diffusivity Evaluation
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. PEG-b-PLA Synthesis
4.3. PEG-b-PLA NPs Synthesis and Drug Loading
4.4. AC-NPs Synthesis
4.5. Rhodamine B Release from AC Hydrogels and AC-NPs Composite System
4.6. NPs Release from AC Hydrogels and Mathematical Modeling
4.7. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Symbols
CS | drug concentration in solution | g mL−1 |
CG | drug concentration within hydrogel | g mL−1 |
CG,0 | drug concentration within hydrogel at time t = 0 | g mL−1 |
D | diffusion coefficient | m2 s−1 |
kC | mass transfer coefficient | m s−1 |
mG,0 | drug mass present inside matrix | g |
r | hydrogel radius | cm |
Sexc | exchange interfacial surface | cm2 |
Sh | Sherwood number | - |
t | time | s |
VG | volume of hydrogel in hydrated state | cm3 |
VS | volume of solution | cm3 |
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Diameter (nm) | PDI (–) | ζ−Potential (mV) | |
---|---|---|---|
NPs_SDS | 75.4 | 0.12 | −21.5 |
NPs_CC | 81.2 | 0.15 | 28.5 |
D 1 (cm2/s) | ||
---|---|---|
pH = 7.4 | pH = 5 | |
AC6-NPs_SDS | 2.99 ± 0.15 | - |
AC6-NPs_CC | - | - |
AC1-NPs_SDS | 2.25 ± 0.18 | 1.34 ± 0.12 |
AC1-NPs_CC | 1.16 ± 0.1 | 1.51 ± 0.16 |
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Mauri, E.; Negri, A.; Rebellato, E.; Masi, M.; Perale, G.; Rossi, F. Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery. Gels 2018, 4, 74. https://doi.org/10.3390/gels4030074
Mauri E, Negri A, Rebellato E, Masi M, Perale G, Rossi F. Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery. Gels. 2018; 4(3):74. https://doi.org/10.3390/gels4030074
Chicago/Turabian StyleMauri, Emanuele, Anna Negri, Erica Rebellato, Maurizio Masi, Giuseppe Perale, and Filippo Rossi. 2018. "Hydrogel-Nanoparticles Composite System for Controlled Drug Delivery" Gels 4, no. 3: 74. https://doi.org/10.3390/gels4030074