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A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures

1
Inspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA
2
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
3
Nano Medical Engineering Laboratory, RIKEN Custer for Pioneering Research, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
4
Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
5
Border Biomedical Research Center, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA
*
Author to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 17 August 2018 / Accepted: 29 August 2018 / Published: 4 September 2018
(This article belongs to the Special Issue The Role of Polymer Additives in Hydrogel Functionalization)
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Abstract

3D bioprinting holds great promise in the field of regenerative medicine as it can create complex structures in a layer-by-layer manner using cell-laden bioinks, making it possible to imitate native tissues. Current bioinks lack both high printability and biocompatibility required in this respect. Hence, the development of bioinks that exhibit both properties is needed. In our previous study, a furfuryl-gelatin-based bioink, crosslinkable by visible light, was used for creating mouse mesenchymal stem cell-laden structures with a high fidelity. In this study, lattice mesh geometries were printed in a comparative study to test against the properties of a traditional rectangular-sheet. After 3D printing and crosslinking, both structures were analysed for swelling and rheological properties, and their porosity was estimated using scanning electron microscopy. The results showed that the lattice structure was relatively more porous with enhanced rheological properties and exhibited a lower degradation rate compared to the rectangular-sheet. Further, the lattice allowed cells to proliferate to a greater extent compared to the rectangular-sheet, which initially retained a lower number of cells. All of these results collectively affirmed that the lattice poses as a superior scaffold design for tissue engineering applications. View Full-Text
Keywords: hydrogels; cardiac patches; 3D bioprinting; furfuryl-gelatin; lattice hydrogels; cardiac patches; 3D bioprinting; furfuryl-gelatin; lattice
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Anil Kumar, S.; Tasnim, N.; Dominguez, E.; Allen, S.; Suggs, L.J.; Ito, Y.; Joddar, B. A Comparative Study of a 3D Bioprinted Gelatin-Based Lattice and Rectangular-Sheet Structures. Gels 2018, 4, 73.

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