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Gels 2017, 3(2), 19; doi:10.3390/gels3020019

A Controlled Antibiotic Release System for the Development of Single-Application Otitis Externa Therapeutics

1
Materials Science Program, University of Montana, Missoula, MT 59812, USA
2
Interdisciplinary Studies Program, University of Montana, Missoula, MT 59812, USA
3
Department of Chemistry and Biochemistry, University of Montana, Missoula, MT 59812, USA
4
Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Alejandro Sosnik and Katia Seremeta
Received: 24 April 2017 / Revised: 11 May 2017 / Accepted: 12 May 2017 / Published: 17 May 2017
(This article belongs to the Special Issue Hydrogels for Drug Delivery)
View Full-Text   |   Download PDF [3506 KB, uploaded 17 May 2017]   |  

Abstract

Ear infections are a commonly-occurring problem that can affect people of all ages. Treatment of these pathologies usually includes the administration of topical or systemic antibiotics, depending on the location of the infection. In this context, we sought to address the feasibility of a single-application slow-releasing therapeutic formulation of an antibiotic for the treatment of otitis externa. Thixotropic hydrogels, which are gels under static conditions but liquefy when shaken, were tested for their ability to act as drug controlled release systems and inhibit Pseudomonas aeruginosa and Staphylococcus aureus, the predominant bacterial strains associated with outer ear infections. Our overall proof of concept, including in vitro evaluations reflective of therapeutic ease of administration, formulation stability, cytocompatibility assessment, antibacterial efficacy, and formulation lifespan, indicate that these thixotropic materials have strong potential for development as otic treatment products. View Full-Text
Keywords: thixotropic; hydrogel; drug release; antibacterial; otic thixotropic; hydrogel; drug release; antibacterial; otic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Serban, B.A.; Stipe, K.T.; Alverson, J.B.; Johnston, E.R.; Priestley, N.D.; Serban, M.A. A Controlled Antibiotic Release System for the Development of Single-Application Otitis Externa Therapeutics. Gels 2017, 3, 19.

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