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Gels 2017, 3(2), 20; doi:10.3390/gels3020020

Bioengineering Microgels and Hydrogel Microparticles for Sensing Biomolecular Targets

1
Interdisciplinary Research Centre on Biomaterials (CRIB) and Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale (DICMAPI), University of Naples Federico II, Piazzale Tecchio 80, 80125 Napoli, Italy
2
Center for Advanced Biomaterials for HealthCare@CRIB, Istituto Italiano di Tecnologia, Largo Barsanti e Matteucci 53, 80125 Napoli, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Gaio Paradossi
Received: 20 March 2017 / Revised: 11 May 2017 / Accepted: 23 May 2017 / Published: 30 May 2017
(This article belongs to the Special Issue Micro- and Nanogels)
View Full-Text   |   Download PDF [2664 KB, uploaded 23 June 2017]   |  

Abstract

Hydrogels, and in particular microgels, are playing an increasingly important role in a diverse range of applications due to their hydrophilic, biocompatible, and highly flexible chemical characteristics. On this basis, solution-like environment, non-fouling nature, easy probe accessibility and target diffusion, effective inclusion of reporting moieties can be achieved, making them ideal substrates for bio-sensing applications. In fact, hydrogels are already successfully used in immunoassays as well as sensitive nucleic acid assays, also enabling hydrogel-based suspension arrays. In this review, we discuss key parameters of hydrogels in the form of micron-sized particles to be used in sensing applications, paying attention to the protein and oligonucleotides (i.e., miRNAs) targets as most representative kind of biomarkers. View Full-Text
Keywords: microgels; hydrogel microparticles; multiplex bead-based assay; core/shell microgels; fluorescent enconding; oligonucleotide probes; immunoassays; microRNAs microgels; hydrogel microparticles; multiplex bead-based assay; core/shell microgels; fluorescent enconding; oligonucleotide probes; immunoassays; microRNAs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Battista, E.; Causa, F.; Netti, P.A. Bioengineering Microgels and Hydrogel Microparticles for Sensing Biomolecular Targets. Gels 2017, 3, 20.

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